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191 related items for PubMed ID: 31436536

  • 1. Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor.
    Li L, Welch MA, Li Z, Mackowiak B, Heyward S, Swaan PW, Wang H.
    Mol Pharmacol; 2019 Sep; 96(3):345-354. PubMed ID: 31436536
    [Abstract] [Full Text] [Related]

  • 2. Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.
    Haines C, Elcombe BM, Chatham LR, Vardy A, Higgins LG, Elcombe CR, Lake BG.
    Toxicology; 2018 Mar 01; 396-397():23-32. PubMed ID: 29425889
    [Abstract] [Full Text] [Related]

  • 3. CITCO Directly Binds to and Activates Human Pregnane X Receptor.
    Lin W, Bwayi M, Wu J, Li Y, Chai SC, Huber AD, Chen T.
    Mol Pharmacol; 2020 Mar 01; 97(3):180-190. PubMed ID: 31882411
    [Abstract] [Full Text] [Related]

  • 4. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.
    Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H.
    J Pharmacol Exp Ther; 2006 Jun 01; 317(3):1200-9. PubMed ID: 16513849
    [Abstract] [Full Text] [Related]

  • 5. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.
    Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H.
    J Pharmacol Exp Ther; 2007 Jan 01; 320(1):72-80. PubMed ID: 17041008
    [Abstract] [Full Text] [Related]

  • 6. Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor.
    Hu Q, Yao N, Wu J, Liu M, Liu F, Zhang H, Xiong Y, Xia C.
    Biochem Pharmacol; 2019 Jan 01; 159():32-39. PubMed ID: 30414935
    [Abstract] [Full Text] [Related]

  • 7. Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
    Preiss LC, Liu R, Hewitt P, Thompson D, Georgi K, Badolo L, Lauschke VM, Petersson C.
    Drug Metab Dispos; 2021 Aug 01; 49(8):668-678. PubMed ID: 34035124
    [Abstract] [Full Text] [Related]

  • 8. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
    Casabar RC, Das PC, Dekrey GK, Gardiner CS, Cao Y, Rose RL, Wallace AD.
    Toxicol Appl Pharmacol; 2010 Jun 15; 245(3):335-43. PubMed ID: 20361990
    [Abstract] [Full Text] [Related]

  • 9. Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor.
    Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TK.
    J Pharmacol Exp Ther; 2011 Mar 15; 336(3):816-26. PubMed ID: 21131266
    [Abstract] [Full Text] [Related]

  • 10. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.
    Wang H, Faucette SR, Gilbert D, Jolley SL, Sueyoshi T, Negishi M, LeCluyse EL.
    Drug Metab Dispos; 2003 May 15; 31(5):620-30. PubMed ID: 12695351
    [Abstract] [Full Text] [Related]

  • 11. Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells.
    Li D, Mackowiak B, Brayman TG, Mitchell M, Zhang L, Huang SM, Wang H.
    Biochem Pharmacol; 2015 Nov 01; 98(1):190-202. PubMed ID: 26275810
    [Abstract] [Full Text] [Related]

  • 12. Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.
    Kanno Y, Tanuma N, Yazawa S, Zhao S, Inaba M, Nakamura S, Nemoto K, Inouye Y.
    Drug Metab Dispos; 2016 Aug 01; 44(8):1158-63. PubMed ID: 27197997
    [Abstract] [Full Text] [Related]

  • 13. Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice.
    Yamada T, Ohara A, Ozawa N, Maeda K, Kondo M, Okuda Y, Abe J, Cohen SM, Lake BG.
    Toxicol Sci; 2020 Oct 01; 177(2):362-376. PubMed ID: 32735318
    [Abstract] [Full Text] [Related]

  • 14. Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes.
    Li Z, Li L, Heyward S, Men S, Xu M, Sueyoshi T, Wang H.
    Cells; 2021 Dec 01; 10(12):. PubMed ID: 34943889
    [Abstract] [Full Text] [Related]

  • 15. Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
    Chang HY, Chen CJ, Ma WC, Cheng WK, Lin YN, Lee YR, Chen JJ, Lim YP.
    Phytomedicine; 2017 Dec 01; 36():37-49. PubMed ID: 29157826
    [Abstract] [Full Text] [Related]

  • 16. Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
    Ross J, Plummer SM, Rode A, Scheer N, Bower CC, Vogel O, Henderson CJ, Wolf CR, Elcombe CR.
    Toxicol Sci; 2010 Aug 01; 116(2):452-66. PubMed ID: 20403969
    [Abstract] [Full Text] [Related]

  • 17. Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.
    Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E.
    J Biol Chem; 2004 Jul 09; 279(28):29295-301. PubMed ID: 15123723
    [Abstract] [Full Text] [Related]

  • 18. Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.
    Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG.
    Toxicol Sci; 2014 Jun 09; 139(2):501-11. PubMed ID: 24690595
    [Abstract] [Full Text] [Related]

  • 19. The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor.
    Ding X, Lichti K, Staudinger JL.
    Toxicol Sci; 2006 Jun 09; 91(2):448-55. PubMed ID: 16547076
    [Abstract] [Full Text] [Related]

  • 20. Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.
    Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TK.
    Drug Metab Dispos; 2012 Jan 09; 40(1):178-86. PubMed ID: 22019630
    [Abstract] [Full Text] [Related]

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