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484 related items for PubMed ID: 31443721

  • 1. ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells.
    Le Clorennec C, Lazrek Y, Dubreuil O, Sampaio C, Larbouret C, Lanotte R, Poul MA, Barret JM, Prost JF, Pèlegrin A, Chardès T.
    Cell Commun Signal; 2019 Aug 23; 17(1):106. PubMed ID: 31443721
    [Abstract] [Full Text] [Related]

  • 2. The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation.
    Le Clorennec C, Lazrek Y, Dubreuil O, Larbouret C, Poul MA, Mondon P, Melino G, Pèlegrin A, Chardès T.
    Oncotarget; 2016 Jun 14; 7(24):37013-37029. PubMed ID: 27203743
    [Abstract] [Full Text] [Related]

  • 3. The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
    Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS, Longley DB.
    Cell Death Differ; 2020 Sep 14; 27(9):2726-2741. PubMed ID: 32313199
    [Abstract] [Full Text] [Related]

  • 4. Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3.
    Le Clorennec C, Bazin H, Dubreuil O, Larbouret C, Ogier C, Lazrek Y, Garambois V, Poul MA, Mondon P, Barret JM, Mathis G, Prost JF, Pèlegrin A, Chardès T.
    Mol Cancer Ther; 2017 Jul 14; 16(7):1312-1323. PubMed ID: 28507002
    [Abstract] [Full Text] [Related]

  • 5. CCAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction and ubiquitin/proteasome-mediated cellular FLICE-inhibitory protein down-regulation contribute to enhancement of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by dimethyl-celecoxib in human non small-cell lung cancer cells.
    Chen S, Liu X, Yue P, Schönthal AH, Khuri FR, Sun SY.
    Mol Pharmacol; 2007 Nov 14; 72(5):1269-79. PubMed ID: 17684158
    [Abstract] [Full Text] [Related]

  • 6. c-FLIP, a master anti-apoptotic regulator.
    Safa AR.
    Exp Oncol; 2012 Oct 14; 34(3):176-84. PubMed ID: 23070002
    [Abstract] [Full Text] [Related]

  • 7. Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIP(L) from degradation by the E3 ligase itch in human melanoma cells.
    Yang F, Tay KH, Dong L, Thorne RF, Jiang CC, Yang E, Tseng HY, Liu H, Christopherson R, Hersey P, Zhang XD.
    Cell Death Differ; 2010 Aug 14; 17(8):1354-67. PubMed ID: 20300110
    [Abstract] [Full Text] [Related]

  • 8. Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis.
    Tiwary R, Yu W, Li J, Park SK, Sanders BG, Kline K.
    PLoS One; 2010 Jul 29; 5(7):e11865. PubMed ID: 20686688
    [Abstract] [Full Text] [Related]

  • 9. GSK3β/ITCH/c-FLIP Axis Counteracts TRAIL-induced Apoptosis in Human Lung Adenocarcinoma Cells.
    Zheng X, Huang D, Liu X, Liu QY, Gao X, Liu L.
    Protein Pept Lett; 2023 Jul 29; 30(3):242-249. PubMed ID: 36644866
    [Abstract] [Full Text] [Related]

  • 10. c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells.
    Day TW, Huang S, Safa AR.
    Biochem Pharmacol; 2008 Dec 15; 76(12):1694-704. PubMed ID: 18840411
    [Abstract] [Full Text] [Related]

  • 11. α-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway.
    Yu W, Tiwary R, Li J, Park SK, Jia L, Xiong A, Simmons-Menchaca M, Sanders BG, Kline K.
    Mol Carcinog; 2010 Nov 15; 49(11):964-73. PubMed ID: 20886583
    [Abstract] [Full Text] [Related]

  • 12. Codium fragile F2 sensitize colorectal cancer cells to TRAIL-induced apoptosis via c-FLIP ubiquitination.
    Park SH, Kim JL, Jeong S, Kim BR, Na YJ, Jo MJ, Yun HK, Jeong YA, Kim DY, Kim BG, You S, Oh SC, Lee DH.
    Biochem Biophys Res Commun; 2019 Jan 01; 508(1):1-8. PubMed ID: 30409427
    [Abstract] [Full Text] [Related]

  • 13. DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.
    Bellail AC, Tse MC, Song JH, Phuphanich S, Olson JJ, Sun SY, Hao C.
    J Cell Mol Med; 2010 Jun 01; 14(6A):1303-17. PubMed ID: 19432816
    [Abstract] [Full Text] [Related]

  • 14. Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing.
    Wilson TR, Redmond KM, McLaughlin KM, Crawford N, Gately K, O'Byrne K, Le-Clorrenec C, Holohan C, Fennell DA, Johnston PG, Longley DB.
    Cell Death Differ; 2009 Oct 01; 16(10):1352-61. PubMed ID: 19543235
    [Abstract] [Full Text] [Related]

  • 15. Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL.
    Yerbes R, López-Rivas A.
    Invest New Drugs; 2012 Apr 01; 30(2):541-7. PubMed ID: 21107885
    [Abstract] [Full Text] [Related]

  • 16. Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines.
    Van Geelen CM, Pennarun B, Ek WB, Le PT, Spierings DC, De Vries EG, De Jong S.
    Int J Oncol; 2010 Oct 01; 37(4):1031-41. PubMed ID: 20811726
    [Abstract] [Full Text] [Related]

  • 17. Protective effect of RIP and c-FLIP in preventing liver cancer cell apoptosis induced by TRAIL.
    Sun J, Luo H, Nie W, Xu X, Miao X, Huang F, Wu H, Jin X.
    Int J Clin Exp Pathol; 2015 Oct 01; 8(6):6519-25. PubMed ID: 26261530
    [Abstract] [Full Text] [Related]

  • 18. Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme.
    Panner A, Crane CA, Weng C, Feletti A, Fang S, Parsa AT, Pieper RO.
    Cancer Res; 2010 Jun 15; 70(12):5046-53. PubMed ID: 20484045
    [Abstract] [Full Text] [Related]

  • 19. The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells.
    Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY.
    Cancer Res; 2007 May 15; 67(10):4981-8. PubMed ID: 17510429
    [Abstract] [Full Text] [Related]

  • 20. Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells.
    Palacios C, Yerbes R, López-Rivas A.
    Cancer Res; 2006 Sep 01; 66(17):8858-69. PubMed ID: 16951203
    [Abstract] [Full Text] [Related]

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