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Journal Abstract Search

438 related items for PubMed ID: 31550660

  • 1. Design, synthesis and biological evaluation of novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potential FAK inhibitors and anticancer agents.
    Wang R, Chen Y, Zhao X, Yu S, Yang B, Wu T, Guo J, Hao C, Zhao D, Cheng M.
    Eur J Med Chem; 2019 Dec 01; 183():111716. PubMed ID: 31550660
    [Abstract] [Full Text] [Related]

  • 2. Discovery of 7H-pyrrolo[2,3-d]pyridine derivatives as potent FAK inhibitors: Design, synthesis, biological evaluation and molecular docking study.
    Wang R, Zhao X, Yu S, Chen Y, Cui H, Wu T, Hao C, Zhao D, Cheng M.
    Bioorg Chem; 2020 Sep 01; 102():104092. PubMed ID: 32707280
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors.
    Wang R, Yu S, Zhao X, Chen Y, Yang B, Wu T, Hao C, Zhao D, Cheng M.
    Eur J Med Chem; 2020 Feb 15; 188():112024. PubMed ID: 31923858
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents.
    Tan H, Liu Y, Gong C, Zhang J, Huang J, Zhang Q.
    Eur J Med Chem; 2021 Nov 05; 223():113670. PubMed ID: 34214842
    [Abstract] [Full Text] [Related]

  • 5. Synthesis, biological evaluation, and molecular docking studies of novel 2-styryl-5-nitroimidazole derivatives containing 1,4-benzodioxan moiety as FAK inhibitors with anticancer activity.
    Duan YT, Yao YF, Huang W, Makawana JA, Teraiya SB, Thumar NJ, Tang DJ, Tao XX, Wang ZC, Jiang AQ, Zhu HL.
    Bioorg Med Chem; 2014 Jun 01; 22(11):2947-54. PubMed ID: 24792811
    [Abstract] [Full Text] [Related]

  • 6. Novel Pyrazolo[3,4-d]pyrimidines as Potential Cytotoxic Agents: Design, Synthesis, Molecular Docking and CDK2 Inhibition.
    Maher M, Kassab AE, Zaher AF, Mahmoud Z.
    Anticancer Agents Med Chem; 2019 Jun 01; 19(11):1368-1381. PubMed ID: 31038080
    [Abstract] [Full Text] [Related]

  • 7. New thieno[3,2-d]pyrimidine-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents, EGFR and ARO inhibitors inducing apoptosis in breast cancer cells.
    Farghaly AM, AboulWafa OM, Baghdadi HH, Abd El Razik HA, Sedra SMY, Shamaa MM.
    Bioorg Chem; 2021 Oct 01; 115():105208. PubMed ID: 34365057
    [Abstract] [Full Text] [Related]

  • 8. Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.
    Choi HS, Wang Z, Richmond W, He X, Yang K, Jiang T, Sim T, Karanewsky D, Gu XJ, Zhou V, Liu Y, Ohmori O, Caldwell J, Gray N, He Y.
    Bioorg Med Chem Lett; 2006 Apr 15; 16(8):2173-6. PubMed ID: 16458503
    [Abstract] [Full Text] [Related]

  • 9. Discovery of novel pyrrolo-pyridine/pyrimidine derivatives bearing pyridazinone moiety as c-Met kinase inhibitors.
    Wang LX, Liu X, Xu S, Tang Q, Duan Y, Xiao Z, Zhi J, Jiang L, Zheng P, Zhu W.
    Eur J Med Chem; 2017 Dec 01; 141():538-551. PubMed ID: 29107421
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo[1,5-a]pyrimidine derivatives as potential c-Met inhibitors.
    Luo G, Ma Y, Liang X, Xie G, Luo Y, Zha D, Wang S, Yu L, Zheng X, Wu W, Zhang C.
    Bioorg Chem; 2020 Nov 01; 104():104356. PubMed ID: 33142417
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
    Wang S, Zhang RH, Zhang H, Wang YC, Yang D, Zhao YL, Yan GY, Xu GB, Guan HY, Zhou YH, Cui DB, Liu T, Li YJ, Liao SG, Zhou M.
    Eur J Med Chem; 2021 Oct 15; 222():113573. PubMed ID: 34091209
    [Abstract] [Full Text] [Related]

  • 12. Discovery of Novel 2,4-Dianilinopyrimidine Derivatives Containing 4-(Morpholinomethyl)phenyl and N-Substituted Benzamides as Potential FAK Inhibitors and Anticancer Agents.
    Han C, Shen K, Wang S, Wang Z, Su F, Wu X, Hu X, Li M, Han J, Wu L.
    Molecules; 2021 Jul 09; 26(14):. PubMed ID: 34299462
    [Abstract] [Full Text] [Related]

  • 13. Molecular Dynamics and Biological Evaluation of 2-chloro-7-cyclopentyl- 7H-pyrrolo[2,3-d]pyrimidine Derivatives Against Breast Cancer.
    Singaram K, Marimuthu D, Baskaran S, Chinaga SK, Shanmugarajan D, Vadivel T.
    Comb Chem High Throughput Screen; 2017 Jul 09; 20(8):703-712. PubMed ID: 28738766
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis and anticancer evaluation of 1H-pyrazolo[3,4-d]pyrimidine derivatives as potent EGFRWT and EGFRT790M inhibitors and apoptosis inducers.
    Gaber AA, Bayoumi AH, El-Morsy AM, Sherbiny FF, Mehany ABM, Eissa IH.
    Bioorg Chem; 2018 Oct 09; 80():375-395. PubMed ID: 29986185
    [Abstract] [Full Text] [Related]

  • 15. Discovery of 4-(Piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine Derivatives as Akt Inhibitors.
    Liu Y, Yin Y, Zhang J, Nomie K, Zhang L, Yang D, Wang ML, Zhao G.
    Arch Pharm (Weinheim); 2016 May 09; 349(5):356-62. PubMed ID: 26991997
    [Abstract] [Full Text] [Related]

  • 16. Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study.
    Lee JH, El-Damasy AK, Seo SH, Gadhe CG, Pae AN, Jeong N, Hong SS, Keum G.
    Bioorg Med Chem; 2018 Nov 15; 26(21):5596-5611. PubMed ID: 30385226
    [Abstract] [Full Text] [Related]

  • 17. Design, Synthesis, In Silico and In Vitro Evaluation of Novel Pyrimidine Derivatives as EGFR Inhibitors.
    Matada GSP, Abbas N, Dhiwar PS, Basu R, Devasahayam G.
    Anticancer Agents Med Chem; 2021 Nov 15; 21(4):451-461. PubMed ID: 32698735
    [Abstract] [Full Text] [Related]

  • 18. 2-Anilinopyrimidine derivatives: Design, synthesis, in vitro anti-proliferative activity, EGFR and ARO inhibitory activity, cell cycle analysis and molecular docking study.
    AboulWafa OM, Daabees HMG, Badawi WA.
    Bioorg Chem; 2020 Jun 15; 99():103798. PubMed ID: 32247112
    [Abstract] [Full Text] [Related]

  • 19. Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities.
    Su Y, Li R, Ning X, Lin Z, Zhao X, Zhou J, Liu J, Jin Y, Yin Y.
    Eur J Med Chem; 2019 Sep 01; 177():32-46. PubMed ID: 31129452
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers.
    Elmetwally SA, Saied KF, Eissa IH, Elkaeed EB.
    Bioorg Chem; 2019 Jul 01; 88():102944. PubMed ID: 31051400
    [Abstract] [Full Text] [Related]

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