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231 related items for PubMed ID: 31551537

  • 1. BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis.
    Huang K, O'Neill KL, Li J, Zhou W, Han N, Pang X, Wu W, Struble L, Borgstahl G, Liu Z, Zhang L, Luo X.
    Cell Res; 2019 Nov; 29(11):942-952. PubMed ID: 31551537
    [Abstract] [Full Text] [Related]

  • 2. Bax/Bak activation in the absence of Bid, Bim, Puma, and p53.
    Zhang J, Huang K, O'Neill KL, Pang X, Luo X.
    Cell Death Dis; 2016 Jun 16; 7(6):e2266. PubMed ID: 27310874
    [Abstract] [Full Text] [Related]

  • 3. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.
    Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.
    J Biol Chem; 2011 Mar 18; 286(11):9382-92. PubMed ID: 21148306
    [Abstract] [Full Text] [Related]

  • 4. BH3 domains other than Bim and Bid can directly activate Bax/Bak.
    Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T.
    J Biol Chem; 2011 Jan 07; 286(1):491-501. PubMed ID: 21041309
    [Abstract] [Full Text] [Related]

  • 5. Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.
    Hockings C, Anwari K, Ninnis RL, Brouwer J, O'Hely M, Evangelista M, Hinds MG, Czabotar PE, Lee EF, Fairlie WD, Dewson G, Kluck RM.
    Cell Death Dis; 2015 Apr 23; 6(4):e1735. PubMed ID: 25906158
    [Abstract] [Full Text] [Related]

  • 6. In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins.
    Senft D, Weber A, Saathoff F, Berking C, Heppt MV, Kammerbauer C, Rothenfusser S, Kellner S, Kurgyis Z, Besch R, Häcker G.
    Cell Death Dis; 2015 Nov 26; 6(11):e1996. PubMed ID: 26610208
    [Abstract] [Full Text] [Related]

  • 7. p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.
    Müer A, Overkamp T, Gillissen B, Richter A, Pretzsch T, Milojkovic A, Dörken B, Daniel PT, Hemmati P.
    J Biol Chem; 2012 May 18; 287(21):17343-17352. PubMed ID: 22354970
    [Abstract] [Full Text] [Related]

  • 8. Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane.
    O'Neill KL, Huang K, Zhang J, Chen Y, Luo X.
    Genes Dev; 2016 Apr 15; 30(8):973-88. PubMed ID: 27056669
    [Abstract] [Full Text] [Related]

  • 9. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.
    Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.
    Nat Cell Biol; 2006 Dec 15; 8(12):1348-58. PubMed ID: 17115033
    [Abstract] [Full Text] [Related]

  • 10. BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.
    Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N.
    J Biol Chem; 2011 Apr 22; 286(16):13905-13. PubMed ID: 21367852
    [Abstract] [Full Text] [Related]

  • 11. BH3-only protein bid participates in the Bcl-2 network in healthy liver cells.
    Hikita H, Takehara T, Kodama T, Shimizu S, Hosui A, Miyagi T, Tatsumi T, Ishida H, Ohkawa K, Li W, Kanto T, Hiramatsu N, Hennighausen L, Yin XM, Hayashi N.
    Hepatology; 2009 Dec 22; 50(6):1972-80. PubMed ID: 19839062
    [Abstract] [Full Text] [Related]

  • 12. Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.
    Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM, Kluck RM.
    J Cell Biol; 2007 Apr 23; 177(2):277-87. PubMed ID: 17452531
    [Abstract] [Full Text] [Related]

  • 13. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.
    Rahmani M, Aust MM, Attkisson E, Williams DC, Ferreira-Gonzalez A, Grant S.
    Cancer Res; 2013 Feb 15; 73(4):1340-51. PubMed ID: 23243017
    [Abstract] [Full Text] [Related]

  • 14. An interconnected hierarchical model of cell death regulation by the BCL-2 family.
    Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Liao CP, Gavathiotis E, Hsieh JJ, Cheng EH.
    Nat Cell Biol; 2015 Oct 15; 17(10):1270-81. PubMed ID: 26344567
    [Abstract] [Full Text] [Related]

  • 15. Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.
    Hockings C, Alsop AE, Fennell SC, Lee EF, Fairlie WD, Dewson G, Kluck RM.
    Cell Death Differ; 2018 Mar 15; 25(4):721-734. PubMed ID: 29459767
    [Abstract] [Full Text] [Related]

  • 16. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
    Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC.
    Science; 2007 Feb 09; 315(5813):856-9. PubMed ID: 17289999
    [Abstract] [Full Text] [Related]

  • 17. Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues.
    Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U, Salvesen GS, Stoka V, Turk V, Turk B.
    J Biol Chem; 2008 Jul 04; 283(27):19140-50. PubMed ID: 18469004
    [Abstract] [Full Text] [Related]

  • 18. Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation.
    Vela L, Gonzalo O, Naval J, Marzo I.
    J Biol Chem; 2013 Feb 15; 288(7):4935-46. PubMed ID: 23283967
    [Abstract] [Full Text] [Related]

  • 19. The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.
    Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T.
    J Biol Chem; 2013 Oct 18; 288(42):30009-30018. PubMed ID: 23986435
    [Abstract] [Full Text] [Related]

  • 20. Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release.
    Sheridan C, Delivani P, Cullen SP, Martin SJ.
    Mol Cell; 2008 Aug 22; 31(4):570-585. PubMed ID: 18722181
    [Abstract] [Full Text] [Related]

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