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617 related items for PubMed ID: 31561354

  • 1. NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies.
    Schulz C, Kammerer S, Küpper JH.
    Clin Hemorheol Microcirc; 2019; 73(1):249-260. PubMed ID: 31561354
    [Abstract] [Full Text] [Related]

  • 2. Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures.
    Herzog N, Hansen M, Miethbauer S, Schmidtke KU, Anderer U, Lupp A, Sperling S, Seehofer D, Damm G, Scheibner K, Küpper JH.
    Cell Biol Int; 2016 Mar; 40(3):341-53. PubMed ID: 26715207
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  • 3. Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.
    Tolosa L, Gómez-Lechón MJ, López S, Guzmán C, Castell JV, Donato MT, Jover R.
    Toxicol Sci; 2016 Jul; 152(1):214-29. PubMed ID: 27208088
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  • 4. Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays.
    Burkard A, Dähn C, Heinz S, Zutavern A, Sonntag-Buck V, Maltman D, Przyborski S, Hewitt NJ, Braspenning J.
    Xenobiotica; 2012 Oct; 42(10):939-56. PubMed ID: 22524704
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  • 5. Optimized protocol for induction of cytochrome P450 enzymes 1A2 and 3A4 in human primary-like hepatocyte cell strain HepaFH3 to study in vitro toxicology.
    Kammerer S, Küpper JH.
    Clin Hemorheol Microcirc; 2018 Oct; 70(4):563-571. PubMed ID: 30347615
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  • 6. Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity.
    Ruoß M, Damm G, Vosough M, Ehret L, Grom-Baumgarten C, Petkov M, Naddalin S, Ladurner R, Seehofer D, Nussler A, Sajadian S.
    Int J Mol Sci; 2019 Jan 16; 20(2):. PubMed ID: 30654452
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  • 7. Inhibition of phase-1 biotransformation and cytostatic effects of diphenyleneiodonium on hepatoblastoma cell line HepG2 and a CYP3A4-overexpressing HepG2 cell clone.
    Schulz C, Jung F, Küpper JH.
    Clin Hemorheol Microcirc; 2021 Jan 16; 79(1):231-243. PubMed ID: 34487034
    [Abstract] [Full Text] [Related]

  • 8. Enhanced DNA adduct formation by benzo[a]pyrene in human liver cells lacking cytochrome P450 oxidoreductase.
    Reed L, Jarvis IWH, Phillips DH, Arlt VM.
    Mutat Res Genet Toxicol Environ Mutagen; 2020 Apr 16; 852():503162. PubMed ID: 32265041
    [Abstract] [Full Text] [Related]

  • 9. One-electron reductive bioactivation of 2,3,5,6-tetramethylbenzoquinone by cytochrome P450.
    Goeptar AR, te Koppele JM, van Maanen JM, Zoetemelk CE, Vermeulen NP.
    Biochem Pharmacol; 1992 Jan 22; 43(2):343-52. PubMed ID: 1310854
    [Abstract] [Full Text] [Related]

  • 10. Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells.
    Heintze T, Klein K, Hofmann U, Zanger UM.
    Sci Rep; 2021 Jan 13; 11(1):1000. PubMed ID: 33441761
    [Abstract] [Full Text] [Related]

  • 11. Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells.
    Ulvestad M, Nordell P, Asplund A, Rehnström M, Jacobsson S, Holmgren G, Davidson L, Brolén G, Edsbagge J, Björquist P, Küppers-Munther B, Andersson TB.
    Biochem Pharmacol; 2013 Sep 01; 86(5):691-702. PubMed ID: 23856292
    [Abstract] [Full Text] [Related]

  • 12. Primary-like Human Hepatocytes Genetically Engineered to Obtain Proliferation Competence as a Capable Application for Energy Metabolism Experiments in In Vitro Oncologic Liver Models.
    Scheffschick A, Babel J, Sperling S, Nerusch J, Herzog N, Seehofer D, Damm G.
    Biology (Basel); 2022 Aug 09; 11(8):. PubMed ID: 36009822
    [Abstract] [Full Text] [Related]

  • 13. The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes.
    Parkinson A, Mudra DR, Johnson C, Dwyer A, Carroll KM.
    Toxicol Appl Pharmacol; 2004 Sep 15; 199(3):193-209. PubMed ID: 15364537
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  • 14. Comparative analysis of 3D culture methods on human HepG2 cells.
    Luckert C, Schulz C, Lehmann N, Thomas M, Hofmann U, Hammad S, Hengstler JG, Braeuning A, Lampen A, Hessel S.
    Arch Toxicol; 2017 Jan 15; 91(1):393-406. PubMed ID: 26872951
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  • 15. The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities.
    Bapiro TE, Martin S, Wilkinson SD, Orton AL, Hariparsad N, Harlfinger S, McGinnity DF.
    Drug Metab Dispos; 2023 Jul 15; 51(7):892-901. PubMed ID: 37041083
    [Abstract] [Full Text] [Related]

  • 16. Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins.
    Gerets HH, Tilmant K, Gerin B, Chanteux H, Depelchin BO, Dhalluin S, Atienzar FA.
    Cell Biol Toxicol; 2012 Apr 15; 28(2):69-87. PubMed ID: 22258563
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  • 17. Deletion of cytochrome P450 oxidoreductase enhances metabolism and DNA adduct formation of benzo[a]pyrene in Hepa1c1c7 cells.
    Reed L, Jarvis IWH, Phillips DH, Arlt VM.
    Mutagenesis; 2019 Dec 19; 34(5-6):413-420. PubMed ID: 31612222
    [Abstract] [Full Text] [Related]

  • 18. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.
    Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F, Guguen-Guillouzo C.
    Chem Biol Interact; 2007 May 20; 168(1):66-73. PubMed ID: 17241619
    [Abstract] [Full Text] [Related]

  • 19. Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures.
    Yokoyama Y, Sasaki Y, Terasaki N, Kawataki T, Takekawa K, Iwase Y, Shimizu T, Sanoh S, Ohta S.
    Biol Pharm Bull; 2018 May 01; 41(5):722-732. PubMed ID: 29445054
    [Abstract] [Full Text] [Related]

  • 20. Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity.
    Chen S, Wu Q, Li X, Li D, Mei N, Ning B, Puig M, Ren Z, Tolleson WH, Guo L.
    J Environ Sci Health C Toxicol Carcinog; 2021 May 01; 39(1):68-86. PubMed ID: 33576714
    [Abstract] [Full Text] [Related]

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