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Journal Abstract Search

130 related items for PubMed ID: 31586716

  • 1. Microwave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II.
    Fouda AM, Assiri MA, Mora A, Ali TE, Afifi TH, El-Agrody AM.
    Bioorg Chem; 2019 Dec; 93():103289. PubMed ID: 31586716
    [Abstract] [Full Text] [Related]

  • 2. A proficient microwave synthesis with structure elucidation and the exploitation of the biological behavior of the newly halogenated 3-amino-1H-benzo[f]chromene molecules, targeting dual inhibition of topoisomerase II and microtubules.
    Fouda AM, Okasha RM, Alblewi FF, Mora A, Afifi TH, El-Agrody AM.
    Bioorg Chem; 2020 Jan; 95():103549. PubMed ID: 31887476
    [Abstract] [Full Text] [Related]

  • 3. Discovery of novel rigid analogs of 2-naphthol with potent anticancer activity through multi-target topoisomerase I & II and tyrosine kinase receptor EGFR & VEGFR-2 inhibition mechanism.
    El-Mawgoud HKA, Fouda AM, El-Nassag MAA, Elhenawy AA, Alshahrani MY, El-Agrody AM.
    Chem Biol Interact; 2022 Mar 01; 355():109838. PubMed ID: 35123995
    [Abstract] [Full Text] [Related]

  • 4. Novel urea linked ciprofloxacin-chalcone hybrids having antiproliferative topoisomerases I/II inhibitory activities and caspases-mediated apoptosis.
    Mohammed HHH, Abbas SH, Hayallah AM, Abuo-Rahma GEA, Mostafa YA.
    Bioorg Chem; 2021 Jan 01; 106():104422. PubMed ID: 33248713
    [Abstract] [Full Text] [Related]

  • 5. Synthesis, anticancer evaluation and molecular docking studies of new heterocycles linked to sulfonamide moiety as novel human topoisomerase types I and II poisons.
    Halawa AH, Elgammal WE, Hassan SM, Hassan AH, Nassar HS, Ebrahim HY, Mehany ABM, El-Agrody AM.
    Bioorg Chem; 2020 May 01; 98():103725. PubMed ID: 32199303
    [Abstract] [Full Text] [Related]

  • 6. Synthesis of β-Enaminonitrile-Linked 8-Methoxy-1H-Benzo[f]Chromene Moieties and Analysis of Their Antitumor Mechanisms.
    Elgaafary M, Fouda AM, Mohamed HM, Hamed A, El-Mawgoud HKA, Jin L, Ulrich J, Simmet T, Syrovets T, El-Agrody AM.
    Front Chem; 2021 May 01; 9():759148. PubMed ID: 34881224
    [Abstract] [Full Text] [Related]

  • 7. Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/IIα inhibitors.
    Arepalli SK, Lee C, Sim S, Lee K, Jo H, Jun KY, Kwon Y, Kang JS, Jung JK, Lee H.
    Bioorg Med Chem; 2018 Oct 01; 26(18):5181-5193. PubMed ID: 30253887
    [Abstract] [Full Text] [Related]

  • 8. Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene.
    Alblewi FF, Okasha RM, Hritani ZM, Mohamed HM, El-Nassag MAA, Halawa AH, Mora A, Fouda AM, Assiri MA, Al-Dies AM, Afifi TH, El-Agrody AM.
    Bioorg Chem; 2019 Jun 01; 87():560-571. PubMed ID: 30928878
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and evaluation of antitumor activity of 9-methoxy-1H-benzo[f]chromene derivatives.
    Elgaafary M, Lehner J, Fouda AM, Hamed A, Ulrich J, Simmet T, Syrovets T, El-Agrody AM.
    Bioorg Chem; 2021 Nov 01; 116():105402. PubMed ID: 34670333
    [Abstract] [Full Text] [Related]

  • 10. New promising levofloxacin derivatives: Design, synthesis, cytotoxic activity screening, Topo2β polymerase inhibition assay, cell cycle apoptosis profile analysis.
    El-Malah A, Youssef A, Ismail M, Kamel M, Mahmoud Z.
    Bioorg Chem; 2021 Aug 01; 113():105029. PubMed ID: 34091290
    [Abstract] [Full Text] [Related]

  • 11. Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis.
    Alblewi FF, Okasha RM, Eskandrani AA, Afifi TH, Mohamed HM, Halawa AH, Fouda AM, Al-Dies AM, Mora A, El-Agrody AM.
    Molecules; 2019 Mar 18; 24(6):. PubMed ID: 30889862
    [Abstract] [Full Text] [Related]

  • 12. 4β-[4'-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents.
    Kamal A, Suresh P, Ramaiah MJ, Srinivasa Reddy T, Kapavarapu RK, Rao BN, Imthiajali S, Lakshminarayan Reddy T, Pushpavalli SN, Shankaraiah N, Pal-Bhadra M.
    Bioorg Med Chem; 2013 Sep 01; 21(17):5198-208. PubMed ID: 23849207
    [Abstract] [Full Text] [Related]

  • 13. Characterization of novel heterocyclic compounds based on 4-aryl-4H-chromene scaffold as anticancer agents: Design, synthesis, antiprofilerative activity against resistant cancer cells, dual β-tubulin/c-Src inhibition, cell cycle arrest and apoptosis induction.
    Abdelall EKA, A H Elshemy H, Labib MB, E A Mohamed F.
    Bioorg Chem; 2022 Mar 01; 120():105591. PubMed ID: 34998122
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor.
    Ahmad P, Woo H, Jun KY, Kadi AA, Abdel-Aziz HA, Kwon Y, Rahman AF.
    Bioorg Med Chem; 2016 Apr 15; 24(8):1898-908. PubMed ID: 26988802
    [Abstract] [Full Text] [Related]

  • 15. A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases.
    Kwon HB, Park C, Jeon KH, Lee E, Park SE, Jun KY, Kadayat TM, Thapa P, Karki R, Na Y, Park MS, Rho SB, Lee ES, Kwon Y.
    J Med Chem; 2015 Feb 12; 58(3):1100-22. PubMed ID: 25603122
    [Abstract] [Full Text] [Related]

  • 16. Oxocrebanine: A Novel Dual Topoisomerase inhibitor, Suppressed the Proliferation of Breast Cancer Cells MCF-7 by Inducing DNA Damage and Mitotic Arrest.
    Yu L, Han S, Lang L, Song H, Zhang C, Dong L, Jia S, Zhang Y, Xiao D, Liu J, Xu Y, Zhang X.
    Phytomedicine; 2021 Apr 12; 84():153504. PubMed ID: 33611211
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.
    Wu WB, Ou JB, Huang ZH, Chen SB, Ou TM, Tan JH, Li D, Shen LL, Huang SL, Gu LQ, Huang ZS.
    Eur J Med Chem; 2011 Aug 12; 46(8):3339-47. PubMed ID: 21600681
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.
    Zhuo ST, Li CY, Hu MH, Chen SB, Yao PF, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS.
    Org Biomol Chem; 2013 Jun 28; 11(24):3989-4005. PubMed ID: 23657605
    [Abstract] [Full Text] [Related]

  • 19. Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity.
    Kassab AE, Gedawy EM.
    Eur J Med Chem; 2018 Apr 25; 150():403-418. PubMed ID: 29547830
    [Abstract] [Full Text] [Related]

  • 20. Synthesis of Novel Pyrazole Derivatives as Promising DNA-Binding Agents and Evaluation of Antitumor and Antitopoisomerases I/II Activities.
    Feng J, Qi H, Sun X, Feng S, Liu Z, Song Y, Qiao X.
    Chem Pharm Bull (Tokyo); 2018 Nov 01; 66(11):1065-1071. PubMed ID: 30197406
    [Abstract] [Full Text] [Related]

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