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Journal Abstract Search

238 related items for PubMed ID: 31648877

  • 1. Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR.
    Sun WX, Han HW, Yang MK, Wen ZL, Wang YS, Fu JY, Lu YT, Wang MY, Bao JX, Lu GH, Qi JL, Wang XM, Lin HY, Yang YH.
    Bioorg Med Chem; 2019 Dec 01; 27(23):115153. PubMed ID: 31648877
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of aryl dihydrothiazol acyl shikonin ester derivatives as anticancer agents through microtubule stabilization.
    Lin HY, Li ZK, Bai LF, Baloch SK, Wang F, Qiu HY, Wang X, Qi JL, Yang RW, Wang XM, Yang YH.
    Biochem Pharmacol; 2015 Jul 15; 96(2):93-106. PubMed ID: 25957661
    [Abstract] [Full Text] [Related]

  • 3. Identification of new shikonin derivatives as STAT3 inhibitors.
    Qiu HY, Fu JY, Yang MK, Han HW, Wang PF, Zhang YH, Lin HY, Tang CY, Qi JL, Yang RW, Wang XM, Zhu HL, Yang YH.
    Biochem Pharmacol; 2017 Dec 15; 146():74-86. PubMed ID: 29066190
    [Abstract] [Full Text] [Related]

  • 4. A novel synthetic compound exerts effective anti-tumour activity in vivo via the inhibition of tubulin polymerisation in A549 cells.
    Yan J, Pang Y, Sheng J, Wang Y, Chen J, Hu J, Huang L, Li X.
    Biochem Pharmacol; 2015 Sep 01; 97(1):51-61. PubMed ID: 26212540
    [Abstract] [Full Text] [Related]

  • 5. Design, Synthesis, and Biological Evaluation of Chalcone-Containing Shikonin Derivatives as Inhibitors of Tubulin Polymerization.
    Qiu HY, Wang F, Wang X, Sun WX, Qi JL, Pang YJ, Yang RW, Lu GH, Wang XM, Yang YH.
    ChemMedChem; 2017 Mar 07; 12(5):399-406. PubMed ID: 28211616
    [Abstract] [Full Text] [Related]

  • 6. Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors.
    Lin HY, Han HW, Sun WX, Yang YS, Tang CY, Lu GH, Qi JL, Wang XM, Yang YH.
    Eur J Med Chem; 2018 Jan 20; 144():137-150. PubMed ID: 29268130
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site.
    Shao YY, Yin Y, Lian BP, Leng JF, Xia YZ, Kong LY.
    Eur J Med Chem; 2020 Mar 15; 190():112105. PubMed ID: 32035399
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and biological evaluation of heterocyclic carboxylic acyl shikonin derivatives.
    Wang XM, Lin HY, Kong WY, Guo J, Shi J, Huang SC, Qi JL, Yang RW, Gu HW, Yang YH.
    Chem Biol Drug Des; 2014 Mar 15; 83(3):334-43. PubMed ID: 24118825
    [Abstract] [Full Text] [Related]

  • 9. Identification of novel 1-indolyl acetate-5-nitroimidazole derivatives of combretastatin A-4 as potential tubulin polymerization inhibitors.
    Yao YF, Wang ZC, Wu SY, Li QF, Yu C, Liang XY, Lv PC, Duan YT, Zhu HL.
    Biochem Pharmacol; 2017 Aug 01; 137():10-28. PubMed ID: 28456516
    [Abstract] [Full Text] [Related]

  • 10. Novel shikonin derivatives targeting tubulin as anticancer agents.
    Guo J, Chen XF, Liu J, Lin HY, Han HW, Liu HC, Huang SC, Shahla BK, Kulek A, Qi JL, Wang XM, Ling LJ, Yang YH.
    Chem Biol Drug Des; 2014 Nov 01; 84(5):603-15. PubMed ID: 24797889
    [Abstract] [Full Text] [Related]

  • 11. Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
    Han H, He C, Chen X, Luo Y, Yang M, Wen Z, Hu J, Lin F, Han M, Yin T, Yang R, Lin H, Qi J, Yang Y.
    Bioorg Med Chem Lett; 2022 Feb 01; 57():128503. PubMed ID: 34922028
    [Abstract] [Full Text] [Related]

  • 12. A potent anticancer agent of shikonin derivative targeting tubulin.
    Baloch SK, Ma L, Xu GH, Bai LF, Zhao H, Tang CY, Pang YJ, Yang RW, Wang XM, Lu GH, Yang YH.
    Chirality; 2015 Mar 01; 27(3):274-80. PubMed ID: 25663187
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.
    Lai Q, Wang Y, Wang R, Lai W, Tang L, Tao Y, Liu Y, Zhang R, Huang L, Xiang H, Zeng S, Gou L, Chen H, Yao Y, Yang J.
    Eur J Med Chem; 2018 Aug 05; 156():162-179. PubMed ID: 30006162
    [Abstract] [Full Text] [Related]

  • 14. Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR.
    Wassel MMS, Ammar YA, Elhag Ali GAM, Belal A, Mehany ABM, Ragab A.
    Bioorg Chem; 2021 May 05; 110():104794. PubMed ID: 33735711
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis, biological evaluation, and 3D-QSAR analysis of podophyllotoxin-dioxazole combination as tubulin targeting anticancer agents.
    Wang ZZ, Sun WX, Wang X, Zhang YH, Qiu HY, Qi JL, Pang YJ, Lu GH, Wang XM, Yu FG, Yang YH.
    Chem Biol Drug Des; 2017 Aug 05; 90(2):236-243. PubMed ID: 28079286
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
    Ma Y, Yang X, Han H, Wen Z, Yang M, Zhang Y, Fu J, Wang X, Yin T, Lu G, Qi J, Lin H, Wang X, Yang Y.
    Bioorg Chem; 2021 Jun 05; 111():104872. PubMed ID: 33838560
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and biological evaluation of novel benzo[c]acridine-diones as potential anticancer agents and tubulin polymerization inhibitors.
    Behbahani FS, Tabeshpour J, Mirzaei S, Golmakaniyoon S, Tayarani-Najaran Z, Ghasemi A, Ghodsi R.
    Arch Pharm (Weinheim); 2019 Jun 05; 352(6):e1800307. PubMed ID: 31012156
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors.
    Qin YJ, Li YJ, Jiang AQ, Yang MR, Zhu QZ, Dong H, Zhu HL.
    Eur J Med Chem; 2015 Apr 13; 94():447-57. PubMed ID: 25828827
    [Abstract] [Full Text] [Related]

  • 19. Synthesis of Combretastatin-A4 Carboxamidest that Mimic Sulfonyl Piperazines by a Molecular Hybridization Approach: in vitro Cytotoxicity Evaluation and Inhibition of Tubulin Polymerization.
    Jadala C, Sathish M, Anchi P, Tokala R, Lakshmi UJ, Reddy VG, Shankaraiah N, Godugu C, Kamal A.
    ChemMedChem; 2019 Dec 17; 14(24):2052-2060. PubMed ID: 31674147
    [Abstract] [Full Text] [Related]

  • 20. Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects.
    Alswah M, Bayoumi AH, Elgamal K, Elmorsy A, Ihmaid S, Ahmed HEA.
    Molecules; 2017 Dec 27; 23(1):. PubMed ID: 29280968
    [Abstract] [Full Text] [Related]

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