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Journal Abstract Search

215 related items for PubMed ID: 31654265

  • 1. A computational study of the molecular basis of antibiotic resistance in a DXR mutant.
    Krebs FS, Esque J, Stote RH.
    J Comput Aided Mol Des; 2019 Oct; 33(10):927-940. PubMed ID: 31654265
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  • 3. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin.
    Dhiman RK, Schaeffer ML, Bailey AM, Testa CA, Scherman H, Crick DC.
    J Bacteriol; 2005 Dec; 187(24):8395-402. PubMed ID: 16321944
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  • 4. A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr).
    Humnabadkar V, Jha RK, Ghatnekar N, De Sousa SM.
    J Biomol Screen; 2011 Mar; 16(3):303-12. PubMed ID: 21335601
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  • 7. The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
    Mac Sweeney A, Lange R, Fernandes RP, Schulz H, Dale GE, Douangamath A, Proteau PJ, Oefner C.
    J Mol Biol; 2005 Jan 07; 345(1):115-27. PubMed ID: 15567415
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  • 9. Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake.
    Brown AC, Parish T.
    BMC Microbiol; 2008 May 20; 8():78. PubMed ID: 18489786
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  • 13. [Evaluation of in vitro antibacterial activity of fosmidomycin and its derivatives].
    Shtannikov AV, Sergeeva EE, Biketov SF, Ostrovskiĭ DN.
    Antibiot Khimioter; 2007 May 20; 52(7-8):3-9. PubMed ID: 18986018
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  • 14. Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.
    Singh N, Chevé G, Avery MA, McCurdy CR.
    Curr Pharm Des; 2007 May 20; 13(11):1161-77. PubMed ID: 17430177
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  • 15. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling.
    Zhang B, Watts KM, Hodge D, Kemp LM, Hunstad DA, Hicks LM, Odom AR.
    Biochemistry; 2011 May 03; 50(17):3570-7. PubMed ID: 21438569
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  • 16. Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin.
    Kholodar SA, Tombline G, Liu J, Tan Z, Allen CL, Gulick AM, Murkin AS.
    Biochemistry; 2014 Jun 03; 53(21):3423-31. PubMed ID: 24825256
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  • 17. Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly.
    Slade JA, Brockett M, Singh R, Liechti GW, Maurelli AT.
    PLoS Pathog; 2019 Oct 03; 15(10):e1008078. PubMed ID: 31622442
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  • 18. α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues.
    Dreneau A, Krebs FS, Munier M, Ngov C, Tritsch D, Lièvremont D, Rohmer M, Grosdemange-Billiard C.
    Molecules; 2021 Aug 23; 26(16):. PubMed ID: 34443699
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  • 19. Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.
    Takenoya M, Ohtaki A, Noguchi K, Endo K, Sasaki Y, Ohsawa K, Yajima S, Yohda M.
    J Struct Biol; 2010 Jun 23; 170(3):532-9. PubMed ID: 20353826
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  • 20. A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Mercklé L, de Andrés-Gómez A, Dick B, Cox RJ, Godfrey CR.
    Chembiochem; 2005 Oct 23; 6(10):1866-74. PubMed ID: 16116659
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