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209 related items for PubMed ID: 31669347

  • 1. Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII.
    Guo Y, Wei L, Zhou Y, Lu N, Tang X, Li Z, Wang X.
    Free Radic Biol Med; 2020 Jan; 146():119-129. PubMed ID: 31669347
    [Abstract] [Full Text] [Related]

  • 2. FV-429 induces apoptosis and inhibits glycolysis by inhibiting Akt-mediated phosphorylation of hexokinase II in MDA-MB-231 cells.
    Zhou Y, Lu N, Qiao C, Ni T, Li Z, Yu B, Guo Q, Wei L.
    Mol Carcinog; 2016 Sep; 55(9):1317-28. PubMed ID: 26258875
    [Abstract] [Full Text] [Related]

  • 3. Gen-27, a newly synthesized flavonoid, inhibits glycolysis and induces cell apoptosis via suppression of hexokinase II in human breast cancer cells.
    Tao L, Wei L, Liu Y, Ding Y, Liu X, Zhang X, Wang X, Yao Y, Lu J, Wang Q, Hu R.
    Biochem Pharmacol; 2017 Feb 01; 125():12-25. PubMed ID: 27818240
    [Abstract] [Full Text] [Related]

  • 4. The Synthetic Flavonoid Derivative GL-V9 Induces Apoptosis and Autophagy in Cutaneous Squamous Cell Carcinoma via Suppressing AKT-Regulated HK2 and mTOR Signals.
    Zhu Y, Liu M, Yao J, Guo Q, Wei L.
    Molecules; 2020 Oct 30; 25(21):. PubMed ID: 33143000
    [Abstract] [Full Text] [Related]

  • 5. Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro.
    Wang K, Fan H, Chen Q, Ma G, Zhu M, Zhang X, Zhang Y, Yu J.
    Anticancer Drugs; 2015 Jan 30; 26(1):15-24. PubMed ID: 25229889
    [Abstract] [Full Text] [Related]

  • 6. GL-V9, a newly synthetic flavonoid derivative, induces mitochondrial-mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells.
    Li L, Lu N, Dai Q, Wei L, Zhao Q, Li Z, He Q, Dai Y, Guo Q.
    Eur J Pharmacol; 2011 Nov 16; 670(1):13-21. PubMed ID: 21944925
    [Abstract] [Full Text] [Related]

  • 7. GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
    Wang R, Min Q, Guo Y, Zhou Y, Zhang X, Wang D, Gao Y, Wei L.
    iScience; 2024 Mar 15; 27(3):109246. PubMed ID: 38439974
    [Abstract] [Full Text] [Related]

  • 8. GL-V9 induced upregulation and mitochondrial localization of NAG-1 associates with ROS generation and cell death in hepatocellular carcinoma cells.
    Zhang X, Kang Y, Huo T, Tao R, Wang X, Li Z, Guo Q, Zhao L.
    Free Radic Biol Med; 2017 Nov 15; 112():49-59. PubMed ID: 28697922
    [Abstract] [Full Text] [Related]

  • 9. Inhibitory effects of GL-V9 on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-2/9.
    Li L, Chen P, Ling Y, Song X, Lu Z, He Q, Li Z, Lu N, Guo Q.
    Eur J Pharm Sci; 2011 Aug 17; 43(5):393-9. PubMed ID: 21683789
    [Abstract] [Full Text] [Related]

  • 10. Gomisin J inhibits the glioma progression by inducing apoptosis and reducing HKII-regulated glycolysis.
    Li R, Yang W.
    Biochem Biophys Res Commun; 2020 Aug 13; 529(1):15-22. PubMed ID: 32560813
    [Abstract] [Full Text] [Related]

  • 11. The overexpression and nuclear translocation of Trx-1 during hypoxia confers on HepG2 cells resistance to DDP, and GL-V9 reverses the resistance by suppressing the Trx-1/Ref-1 axis.
    Zhao L, Li W, Zhou Y, Zhang Y, Huang S, Xu X, Li Z, Guo Q.
    Free Radic Biol Med; 2015 May 13; 82():29-41. PubMed ID: 25656992
    [Abstract] [Full Text] [Related]

  • 12. Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II.
    Bryan N, Raisch KP.
    Biosci Rep; 2015 Apr 24; 35(3):. PubMed ID: 26182367
    [Abstract] [Full Text] [Related]

  • 13. Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate.
    Chen Z, Zhang H, Lu W, Huang P.
    Biochim Biophys Acta; 2009 May 24; 1787(5):553-60. PubMed ID: 19285479
    [Abstract] [Full Text] [Related]

  • 14. Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells.
    Yang D, Tian X, Ye Y, Liang Y, Zhao J, Wu T, Lu N.
    Life Sci; 2021 May 01; 272():119196. PubMed ID: 33617857
    [Abstract] [Full Text] [Related]

  • 15. Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3.
    Gimenez-Cassina A, Lim F, Cerrato T, Palomo GM, Diaz-Nido J.
    J Biol Chem; 2009 Jan 30; 284(5):3001-3011. PubMed ID: 19033437
    [Abstract] [Full Text] [Related]

  • 16. GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis.
    Hu P, Li H, Yu X, Liu X, Wang X, Qing Y, Wang Z, Wang H, Zhu M, Xu J, Tan R, Guo Q, Hui H.
    Free Radic Biol Med; 2019 Dec 30; 145():237-249. PubMed ID: 31560953
    [Abstract] [Full Text] [Related]

  • 17. Activation of phospholipase C-γ1 and translocation of phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase contribute to GL-V9-induced apoptosis in human gastric cancer cells.
    Zhao K, Li G, Yao Y, Zhou Y, Li Z, Guo Q, Lu N.
    Exp Cell Res; 2017 Jul 01; 356(1):8-19. PubMed ID: 28412247
    [Abstract] [Full Text] [Related]

  • 18. Cerulenin-induced apoptosis is mediated by disrupting the interaction between AIF and hexokinase II.
    Jeong NY, Yoo YH.
    Int J Oncol; 2012 Jun 01; 40(6):1949-56. PubMed ID: 22426850
    [Abstract] [Full Text] [Related]

  • 19. Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells.
    Woldetsadik AD, Vogel MC, Rabeh WM, Magzoub M.
    FASEB J; 2017 May 01; 31(5):2168-2184. PubMed ID: 28183803
    [Abstract] [Full Text] [Related]

  • 20. Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy.
    Krasnov GS, Dmitriev AA, Lakunina VA, Kirpiy AA, Kudryavtseva AV.
    Expert Opin Ther Targets; 2013 Oct 01; 17(10):1221-33. PubMed ID: 23984984
    [Abstract] [Full Text] [Related]

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