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178 related items for PubMed ID: 3167828

  • 21. New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.
    Schmid FA, Sirotnak FM, Otter GM, DeGraw JI.
    Cancer Treat Rep; 1985 May; 69(5):551-3. PubMed ID: 4005878
    [Abstract] [Full Text] [Related]

  • 22. A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice.
    Sirotnak FM, DeGraw JI, Colwell WT, Piper JR.
    Cancer Chemother Pharmacol; 1998 May; 42(4):313-8. PubMed ID: 9744777
    [Abstract] [Full Text] [Related]

  • 23. Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors.
    Sirotnak FM, Otter GM, Schmid FA.
    Cancer Res; 1993 Feb 01; 53(3):587-91. PubMed ID: 8425192
    [Abstract] [Full Text] [Related]

  • 24. Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues.
    Stone SR, Montgomery JA, Morrison JF.
    Biochem Pharmacol; 1984 Jan 15; 33(2):175-9. PubMed ID: 6367748
    [Abstract] [Full Text] [Related]

  • 25. Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.
    Rosowsky A, Forsch RA, Wright JE.
    J Med Chem; 2004 Dec 30; 47(27):6958-63. PubMed ID: 15615544
    [Abstract] [Full Text] [Related]

  • 26. Mechanisms of sensitivity and natural resistance to antifolates in a methylcholanthrene-induced rat sarcoma.
    Li WW, Lin JT, Schweitzer BI, Bertino JR.
    Mol Pharmacol; 1991 Nov 30; 40(5):854-8. PubMed ID: 1719370
    [Abstract] [Full Text] [Related]

  • 27. Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse.
    Samuels LL, Goutas LJ, Priest DG, Piper JR, Sirotnak FM.
    Cancer Res; 1986 May 30; 46(5):2230-5. PubMed ID: 2421872
    [Abstract] [Full Text] [Related]

  • 28. Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity.
    Rumberger BG, Schmid FA, Otter GM, Sirotnak FM.
    Cancer Commun; 1990 May 30; 2(9):305-10. PubMed ID: 2206778
    [Abstract] [Full Text] [Related]

  • 29. Enhancement of folate analogue transport inward in L1210 cells during methotrexate therapy of leukemic mice: evidence of the nature of the effect, possible host mediation, and pharmacokinetic significance.
    Sirotnak FM, Poser RE, Barrueco JR.
    Cancer Res; 1987 Oct 15; 47(20):5334-9. PubMed ID: 3498533
    [Abstract] [Full Text] [Related]

  • 30. Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization.
    McGuire JJ, Bergoltz VV, Heitzman KJ, Haile WH, Russell CA, Bolanowska WE, Kotake Y, Haneda T, Nomura H.
    Cancer Res; 1994 May 15; 54(10):2673-9. PubMed ID: 8168096
    [Abstract] [Full Text] [Related]

  • 31. Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate.
    Krug LM, Ng KK, Kris MG, Miller VA, Tong W, Heelan RT, Leon L, Leung D, Kelly J, Grant SC, Sirotnak FM.
    Clin Cancer Res; 2000 Sep 15; 6(9):3493-8. PubMed ID: 10999734
    [Abstract] [Full Text] [Related]

  • 32. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
    Westerhof GR, Schornagel JH, Kathmann I, Jackman AL, Rosowsky A, Forsch RA, Hynes JB, Boyle FT, Peters GJ, Pinedo HM.
    Mol Pharmacol; 1995 Sep 15; 48(3):459-71. PubMed ID: 7565626
    [Abstract] [Full Text] [Related]

  • 33. Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain.
    Rosowsky A, Moran RC, Forsch RA, Radike-Smith M, Colman PD, Wick MM, Freisheim JH.
    Biochem Pharmacol; 1986 Oct 01; 35(19):3327-33. PubMed ID: 3768024
    [Abstract] [Full Text] [Related]

  • 34. Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.
    Rosowsky A, Bader H, Radike-Smith M, Cucchi CA, Wick MM, Freisheim JH.
    J Med Chem; 1986 Sep 01; 29(9):1703-9. PubMed ID: 3462394
    [Abstract] [Full Text] [Related]

  • 35. Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
    Piper JR, Malik ND, Rhee MS, Galivan J, Sirotnak FM.
    J Med Chem; 1992 Jan 24; 35(2):332-7. PubMed ID: 1732551
    [Abstract] [Full Text] [Related]

  • 36. Therapeutic relevance of differences in the structural specificity of the transport systems for folate analogs in L1210 tumor cells and in isolated murine intestinal epithelial cells.
    Chello PL, Sirotnak FM, Dorick DM, Donsbach RC.
    Cancer Res; 1977 Dec 24; 37(12):4297-303. PubMed ID: 922722
    [No Abstract] [Full Text] [Related]

  • 37. Analogues of methotrexate in rheumatoid arthritis. 1. Effects of 10-deazaaminopterin analogues on type II collagen-induced arthritis in mice.
    DeGraw JI, Colwell WT, Crase J, Smith RL, Piper JR, Waud WR, Sirotnak FM.
    J Med Chem; 1997 Jan 31; 40(3):370-6. PubMed ID: 9022804
    [Abstract] [Full Text] [Related]

  • 38. Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
    Rosowsky A, Bader H, Kohler W, Freisheim JH, Moran RG.
    J Med Chem; 1988 Jul 31; 31(7):1338-44. PubMed ID: 2898531
    [Abstract] [Full Text] [Related]

  • 39. Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
    Rosowsky A, Forsch RA, Bader H, Freisheim JH.
    J Med Chem; 1991 Apr 31; 34(4):1447-54. PubMed ID: 2016722
    [Abstract] [Full Text] [Related]

  • 40. Enhanced polyglutamylation of aminopterin relative to methotrexate in the Ehrlich ascites tumor cell in vitro.
    Matherly LH, Voss MK, Anderson LA, Fry DW, Goldman ID.
    Cancer Res; 1985 Mar 31; 45(3):1073-8. PubMed ID: 2578870
    [Abstract] [Full Text] [Related]

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