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154 related items for PubMed ID: 31698846

  • 1. Effect of Kinase Inhibiting RNase Attenuator (KIRA) Compounds on the Formation of Face-to-Face Dimers of Inositol-Requiring Enzyme 1: Insights from Computational Modeling.
    Carlesso A, Chintha C, Gorman AM, Samali A, Eriksson LA.
    Int J Mol Sci; 2019 Nov 06; 20(22):. PubMed ID: 31698846
    [Abstract] [Full Text] [Related]

  • 2. New insights on human IRE1 tetramer structures based on molecular modeling.
    Carlesso A, Hörberg J, Reymer A, Eriksson LA.
    Sci Rep; 2020 Oct 15; 10(1):17490. PubMed ID: 33060689
    [Abstract] [Full Text] [Related]

  • 3. Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands.
    Ferri E, Le Thomas A, Wallweber HA, Day ES, Walters BT, Kaufman SE, Braun MG, Clark KR, Beresini MH, Mortara K, Chen YA, Canter B, Phung W, Liu PS, Lammens A, Ashkenazi A, Rudolph J, Wang W.
    Nat Commun; 2020 Dec 14; 11(1):6387. PubMed ID: 33318494
    [Abstract] [Full Text] [Related]

  • 4. Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain.
    Carlesso A, Chintha C, Gorman AM, Samali A, Eriksson LA.
    ACS Omega; 2018 Oct 31; 3(10):13313-13322. PubMed ID: 30411035
    [Abstract] [Full Text] [Related]

  • 5. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
    Concha NO, Smallwood A, Bonnette W, Totoritis R, Zhang G, Federowicz K, Yang J, Qi H, Chen S, Campobasso N, Choudhry AE, Shuster LE, Evans KA, Ralph J, Sweitzer S, Heerding DA, Buser CA, Su DS, DeYoung MP.
    Mol Pharmacol; 2015 Dec 31; 88(6):1011-23. PubMed ID: 26438213
    [Abstract] [Full Text] [Related]

  • 6. Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.
    Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ.
    ACS Chem Biol; 2016 Aug 19; 11(8):2195-205. PubMed ID: 27227314
    [Abstract] [Full Text] [Related]

  • 7. Opposite Roles of RNase and Kinase Activities of Inositol-Requiring Enzyme 1 (IRE1) on HSV-1 Replication.
    Su A, Wang H, Li Y, Wang X, Chen D, Wu Z.
    Viruses; 2017 Aug 23; 9(9):. PubMed ID: 28832521
    [Abstract] [Full Text] [Related]

  • 8. Sensor dimer disruption as a new mode of action to block the IRE1-mediated unfolded protein response.
    Amarasinghe KN, Pelizzari-Raymundo D, Carlesso A, Chevet E, Eriksson LA, Jalil Mahdizadeh S.
    Comput Struct Biotechnol J; 2022 Aug 23; 20():1584-1592. PubMed ID: 35465159
    [Abstract] [Full Text] [Related]

  • 9. Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.
    Joshi A, Newbatt Y, McAndrew PC, Stubbs M, Burke R, Richards MW, Bhatia C, Caldwell JJ, McHardy T, Collins I, Bayliss R.
    Oncotarget; 2015 May 30; 6(15):13019-35. PubMed ID: 25968568
    [Abstract] [Full Text] [Related]

  • 10. Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors.
    Carlesso A, Chintha C, Gorman AM, Samali A, Eriksson LA.
    Sci Rep; 2019 Mar 04; 9(1):3407. PubMed ID: 30833722
    [Abstract] [Full Text] [Related]

  • 11. Structural Insights into IRE1 Functions in the Unfolded Protein Response.
    Yang J, Liu H, Li L, Liu H, Shi W, Yuan X, Wu L.
    Curr Med Chem; 2016 Mar 04; 23(41):4706-4716. PubMed ID: 27686654
    [Abstract] [Full Text] [Related]

  • 12. Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α.
    Itzhak D, Bright M, McAndrew P, Mirza A, Newbatt Y, Strover J, Widya M, Thompson A, Morgan G, Collins I, Davies F.
    BMC Biochem; 2014 Feb 13; 15():3. PubMed ID: 24524643
    [Abstract] [Full Text] [Related]

  • 13. Herpes Simplex Virus 1 UL41 Protein Suppresses the IRE1/XBP1 Signal Pathway of the Unfolded Protein Response via Its RNase Activity.
    Zhang P, Su C, Jiang Z, Zheng C.
    J Virol; 2017 Feb 15; 91(4):. PubMed ID: 27928013
    [Abstract] [Full Text] [Related]

  • 14. The unfolded protein response signals through high-order assembly of Ire1.
    Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P.
    Nature; 2009 Feb 05; 457(7230):687-93. PubMed ID: 19079236
    [Abstract] [Full Text] [Related]

  • 15. On the mechanism of sensing unfolded protein in the endoplasmic reticulum.
    Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P.
    Proc Natl Acad Sci U S A; 2005 Dec 27; 102(52):18773-84. PubMed ID: 16365312
    [Abstract] [Full Text] [Related]

  • 16. Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor.
    Korovesis D, Rufo N, Derua R, Agostinis P, Verhelst SHL.
    ACS Chem Biol; 2020 Dec 18; 15(12):3106-3111. PubMed ID: 33290055
    [Abstract] [Full Text] [Related]

  • 17. Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease.
    Colombano G, Caldwell JJ, Matthews TP, Bhatia C, Joshi A, McHardy T, Mok NY, Newbatt Y, Pickard L, Strover J, Hedayat S, Walton MI, Myers SM, Jones AM, Saville H, McAndrew C, Burke R, Eccles SA, Davies FE, Bayliss R, Collins I.
    J Med Chem; 2019 Mar 14; 62(5):2447-2465. PubMed ID: 30779566
    [Abstract] [Full Text] [Related]

  • 18. Regulation of IRE1 RNase activity by the Ribonuclease inhibitor 1 (RNH1).
    Tavernier Q, Bennana E, Poindessous V, Schaeffer C, Rampoldi L, Pietrancosta N, Pallet N.
    Cell Cycle; 2018 Mar 14; 17(15):1901-1916. PubMed ID: 30109813
    [Abstract] [Full Text] [Related]

  • 19. Pharmacological Targeting of IRE1 in Cancer.
    Raymundo DP, Doultsinos D, Guillory X, Carlesso A, Eriksson LA, Chevet E.
    Trends Cancer; 2020 Dec 14; 6(12):1018-1030. PubMed ID: 32861679
    [Abstract] [Full Text] [Related]

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