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Journal Abstract Search

434 related items for PubMed ID: 31841727

  • 1. Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer.
    Tokay E, Güngör T, Hacıoğlu N, Önder FC, Gülhan ÜG, Tok TT, Çelik A, Ay M, Köçkar F.
    Eur J Med Chem; 2020 Feb 01; 187():111937. PubMed ID: 31841727
    [Abstract] [Full Text] [Related]

  • 2. Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation.
    Güngör T, Tokay E, Güven Gülhan Ü, Hacıoğlu N, Çelik A, Köçkar F, Ay M.
    Bioorg Chem; 2020 Dec 01; 105():104450. PubMed ID: 33189994
    [Abstract] [Full Text] [Related]

  • 3. Prodrugs for Nitroreductase Based Cancer Therapy- 1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB.
    Gungor T, Yetis G, Onder FC, Tokay E, Tok TT, Celik A, Ay M, Kockar F.
    Med Chem; 2018 Dec 01; 14(5):495-507. PubMed ID: 29189173
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  • 5. Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.
    Johansson E, Parkinson GN, Denny WA, Neidle S.
    J Med Chem; 2003 Sep 11; 46(19):4009-20. PubMed ID: 12954054
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  • 6. Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
    Jiang Y, Han J, Yu C, Vass SO, Searle PF, Browne P, Knox RJ, Hu L.
    J Med Chem; 2006 Jul 13; 49(14):4333-43. PubMed ID: 16821793
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  • 7. Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs.
    Burke PJ, Wong LC, Jenkins TC, Knox RJ, Meikle IT, Stanforth SP.
    Bioorg Med Chem Lett; 2016 Dec 15; 26(24):5851-5854. PubMed ID: 27876476
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  • 8. Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
    Hay MP, Anderson RF, Ferry DM, Wilson WR, Denny WA.
    J Med Chem; 2003 Dec 04; 46(25):5533-45. PubMed ID: 14640560
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  • 9. Self-immolative prodrugs: candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme.
    Mauger AB, Burke PJ, Somani HH, Friedlos F, Knox RJ.
    J Med Chem; 1994 Oct 14; 37(21):3452-8. PubMed ID: 7932574
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  • 10. Anticancer activities of emetine prodrugs that are proteolytically activated by the prostate specific antigen (PSA) and evaluation of in vivo toxicity of emetine derivatives.
    Akinboye ES, Rosen MD, Bakare O, Denmeade SR.
    Bioorg Med Chem; 2017 Dec 15; 25(24):6707-6717. PubMed ID: 29153549
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  • 11. Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).
    Hay MP, Wilson WR, Denny WA.
    Bioorg Med Chem Lett; 1999 Dec 20; 9(24):3417-22. PubMed ID: 10617083
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  • 12. An unusually cold active nitroreductase for prodrug activations.
    Çelik A, Yetiş G.
    Bioorg Med Chem; 2012 Jun 01; 20(11):3540-50. PubMed ID: 22546205
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  • 14. Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy.
    Mowday AM, Ashoorzadeh A, Williams EM, Copp JN, Silva S, Bull MR, Abbattista MR, Anderson RF, Flanagan JU, Guise CP, Ackerley DF, Smaill JB, Patterson AV.
    Biochem Pharmacol; 2016 Sep 15; 116():176-87. PubMed ID: 27453434
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  • 18. Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy.
    Akinboye ES, Brennen WN, Rosen DM, Bakare O, Denmeade SR.
    Prostate; 2016 Jun 15; 76(8):703-14. PubMed ID: 26835873
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  • 20. Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy.
    Chan-Hyams JVE, Copp JN, Smaill JB, Patterson AV, Ackerley DF.
    Biochem Pharmacol; 2018 Dec 15; 158():192-200. PubMed ID: 30352235
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