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128 related items for PubMed ID: 3190731

  • 1. Enhancement of DNA damage in mammalian cells upon bioreduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131.
    Jenner TJ, Sapora O, O'Neill P, Fielden EM.
    Biochem Pharmacol; 1988 Oct 15; 37(20):3837-42. PubMed ID: 3190731
    [Abstract] [Full Text] [Related]

  • 2. The repair of DNA damage induced in V79 mammalian cells by the nitroimidazole-aziridine, RSU-1069. Implications for radiosensitization.
    Jenner TJ, O'Neill P, Crump PW, Fielden EM, Sapora O, Santodonato L.
    Biochem Pharmacol; 1991 Oct 09; 42(9):1705-10. PubMed ID: 1930296
    [Abstract] [Full Text] [Related]

  • 3. Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione.
    Sapora O, Paone A, Maggi A, Jenner TJ, O'Neill P.
    Biochem Pharmacol; 1992 Oct 06; 44(7):1341-7. PubMed ID: 1417957
    [Abstract] [Full Text] [Related]

  • 4. Induction of DNA crosslinks in vitro upon reduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131.
    O'Neill P, McNeil SS, Jenkins TC.
    Biochem Pharmacol; 1987 Jun 01; 36(11):1787-92. PubMed ID: 3579973
    [Abstract] [Full Text] [Related]

  • 5. Assessment of the repair and damage of DNA induced by parent and reduced RSU-1069, a 2-nitroimidazole-aziridine.
    O'Neill P, Cunniffe SM.
    Int J Radiat Oncol Biol Phys; 1989 Apr 01; 16(4):963-6. PubMed ID: 2649467
    [Abstract] [Full Text] [Related]

  • 6. A comparison of the techniques of alkaline filter elution and alkaline sucrose sedimentation used to assess DNA damage induced by 2-nitroimidazoles.
    Crump PW, Fielden EM, Jenner TJ, O'Neill P.
    Biochem Pharmacol; 1990 Aug 01; 40(3):621-7. PubMed ID: 2383289
    [Abstract] [Full Text] [Related]

  • 7. Comparative DNA damage and repair induced by misonidazole, CB 1954 and RSU 1069.
    Dale LD, Widdick DA, Edwards DI, Biol GI.
    Int J Radiat Oncol Biol Phys; 1989 Apr 01; 16(4):995-9. PubMed ID: 2649469
    [Abstract] [Full Text] [Related]

  • 8. Variation of the radiosensitizing efficiency of RSU-1069 with pre-irradiation contact times: a rapid mix study.
    Austen KR, Jenner TJ, O'Neill P, Fielden EM.
    Int J Radiat Biol Relat Stud Phys Chem Med; 1987 Aug 01; 52(2):281-8. PubMed ID: 3497125
    [Abstract] [Full Text] [Related]

  • 9. Cytotoxicity of RSU 1069 in spheroids and murine tumors.
    Olive PL, Durand RE, Chaplin DJ.
    Int J Radiat Oncol Biol Phys; 1987 Sep 01; 13(9):1361-6. PubMed ID: 3624045
    [Abstract] [Full Text] [Related]

  • 10. The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action.
    Stratford IJ, Walling JM, Silver AR.
    Br J Cancer; 1986 Mar 01; 53(3):339-44. PubMed ID: 3754453
    [Abstract] [Full Text] [Related]

  • 11. Studies with bifunctional bioreductive drugs. II. Cytotoxicity assayed with A-549 lung carcinoma cells of human origin.
    Roizin-Towle L, Pirro JP, Hall EJ.
    Radiat Res; 1990 Oct 01; 124(1 Suppl):S50-5. PubMed ID: 2236511
    [Abstract] [Full Text] [Related]

  • 12. RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo.
    Adams GE, Ahmed I, Sheldon PW, Stratford IJ.
    Int J Radiat Oncol Biol Phys; 1984 Sep 01; 10(9):1653-6. PubMed ID: 6548211
    [Abstract] [Full Text] [Related]

  • 13. Induction of DNA strand breaks by reduced nitroimidazoles. Implications for DNA base damage.
    Silver AR, McNeil SS, O'Neill P, Jenkins TC, Ahmed I.
    Biochem Pharmacol; 1986 Nov 15; 35(22):3923-8. PubMed ID: 3778516
    [Abstract] [Full Text] [Related]

  • 14. Studies on the toxicity of RSU-1069.
    Whitmore GF, Gulyas S.
    Int J Radiat Oncol Biol Phys; 1986 Jul 15; 12(7):1219-22. PubMed ID: 3755716
    [Abstract] [Full Text] [Related]

  • 15. Induction of DNA strand breaks by RSU-1069, a nitroimidazole-aziridine radiosensitizer. Role of binding of both unreduced and radiation-reduced forms to DNA, in vitro.
    Silver AR, O'Neill P, Jenkins TC.
    Biochem Pharmacol; 1985 Oct 01; 34(19):3537-42. PubMed ID: 3902026
    [Abstract] [Full Text] [Related]

  • 16. Mechanism of action of some bioreducible 2-nitroimidazoles: comparison of in vitro cytotoxicity and ability to induce DNA strand breakage.
    O'Neill P, Jenkins TC, Stratford IJ, Silver AR, Ahmed I, McNeil SS, Fielden EM, Adams GE.
    Anticancer Drug Des; 1987 Apr 01; 1(4):271-80. PubMed ID: 3450299
    [Abstract] [Full Text] [Related]

  • 17. The phosphate-group of DNA as a potential target for RSU-1069, a nitroimidazole-aziridine radiosensitizer.
    Silver AR, O'Neill P, Jenkins TC, McNeil SS.
    Int J Radiat Oncol Biol Phys; 1986 Jul 01; 12(7):1203-6. PubMed ID: 3755715
    [Abstract] [Full Text] [Related]

  • 18. The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation.
    Keohane A, Godden J, Stratford IJ, Adams GE.
    Br J Cancer; 1990 May 01; 61(5):722-6. PubMed ID: 2110815
    [Abstract] [Full Text] [Related]

  • 19. Comparative DNA damage induced by nitroimidazole-aziridine drugs: 1. Effects of methyl substitution on drug action.
    Dale LD, Tocher JH, Edwards DI.
    Anticancer Drug Des; 1988 Dec 01; 3(3):169-75. PubMed ID: 3207464
    [Abstract] [Full Text] [Related]

  • 20. RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions.
    Stratford IJ, O'Neill P, Sheldon PW, Silver AR, Walling JM, Adams GE.
    Biochem Pharmacol; 1986 Jan 01; 35(1):105-9. PubMed ID: 3753579
    [No Abstract] [Full Text] [Related]

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