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162 related items for PubMed ID: 31974452

  • 1. Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes.
    Zhu J, Singh M, Selivanova G, Peuget S.
    Sci Rep; 2020 Jan 23; 10(1):1049. PubMed ID: 31974452
    [Abstract] [Full Text] [Related]

  • 2. ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53.
    Lee SY, Shin SJ, Kim HS.
    Int J Oncol; 2013 Mar 23; 42(3):1027-35. PubMed ID: 23314357
    [Abstract] [Full Text] [Related]

  • 3. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.
    Saha MN, Jiang H, Chang H.
    Cancer Biol Ther; 2010 Sep 15; 10(6):567-78. PubMed ID: 20595817
    [Abstract] [Full Text] [Related]

  • 4. Pifithrin-alpha decreases the radioprotective efficacy of a Podophyllum hexandrum Himalayan mayapple fraction REC-2006 in HepG2 cells.
    Singh PK, Kumar R, Sharma A, Arora R, Jain SK, Sharma RK.
    Biotechnol Appl Biochem; 2009 Jul 09; 54(1):53-64. PubMed ID: 19409072
    [Abstract] [Full Text] [Related]

  • 5. The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells.
    Vaseva AV, Marchenko ND, Moll UM.
    Cell Cycle; 2009 Jun 01; 8(11):1711-9. PubMed ID: 19411846
    [Abstract] [Full Text] [Related]

  • 6. An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines.
    Walton MI, Wilson SC, Hardcastle IR, Mirza AR, Workman P.
    Mol Cancer Ther; 2005 Sep 01; 4(9):1369-77. PubMed ID: 16170029
    [Abstract] [Full Text] [Related]

  • 7. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53.
    Choe YJ, Lee SY, Ko KW, Shin SJ, Kim HS.
    Int J Oncol; 2014 Mar 01; 44(3):761-8. PubMed ID: 24366007
    [Abstract] [Full Text] [Related]

  • 8. P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK.
    Fan S, Qi M, Yu Y, Li L, Yao G, Tashiro S, Onodera S, Ikejima T.
    Free Radic Res; 2012 Mar 01; 46(3):310-9. PubMed ID: 22283740
    [Abstract] [Full Text] [Related]

  • 9. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines.
    Kitagawa M, Aonuma M, Lee SH, Fukutake S, McCormick F.
    Oncogene; 2008 Sep 11; 27(40):5303-14. PubMed ID: 18521084
    [Abstract] [Full Text] [Related]

  • 10. Pifithrin-α, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the MyD88-independent pathway.
    Mendjargal A, Odkhuu E, Koide N, Nagata H, Kurokawa T, Nonami T, Yokochi T.
    Int Immunopharmacol; 2013 Apr 11; 15(4):671-8. PubMed ID: 23454130
    [Abstract] [Full Text] [Related]

  • 11. P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway.
    Zeng L, Zhang F, Zhang Z, Xu M, Xu Y, Liu Y, Xu H, Sun X, Sang M, Luo H.
    J Biochem Mol Toxicol; 2021 Aug 11; 35(8):e22822. PubMed ID: 34091999
    [Abstract] [Full Text] [Related]

  • 12. Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.
    Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S.
    Leukemia; 2009 Nov 11; 23(11):2090-101. PubMed ID: 19710698
    [Abstract] [Full Text] [Related]

  • 13. Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis.
    Liang L, Zhang Z.
    Cell Physiol Biochem; 2016 Nov 11; 38(4):1618-30. PubMed ID: 27119348
    [Abstract] [Full Text] [Related]

  • 14. Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.
    Yang LY, Greig NH, Huang YN, Hsieh TH, Tweedie D, Yu QS, Hoffer BJ, Luo Y, Kao YC, Wang JY.
    Neurobiol Dis; 2016 Dec 11; 96():216-226. PubMed ID: 27553877
    [Abstract] [Full Text] [Related]

  • 15. Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.
    Yang LY, Chu YH, Tweedie D, Yu QS, Pick CG, Hoffer BJ, Greig NH, Wang JY.
    Exp Neurol; 2015 Jul 11; 269():56-66. PubMed ID: 25819102
    [Abstract] [Full Text] [Related]

  • 16. The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor.
    Hoagland MS, Hoagland EM, Swanson HI.
    J Pharmacol Exp Ther; 2005 Aug 11; 314(2):603-10. PubMed ID: 15843497
    [Abstract] [Full Text] [Related]

  • 17. Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.
    Farah IO, Begum RA, Ishaque AB.
    Biomed Sci Instrum; 2007 Aug 11; 43():116-21. PubMed ID: 17487067
    [Abstract] [Full Text] [Related]

  • 18. MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells.
    Wang B, Fang L, Zhao H, Xiang T, Wang D.
    Acta Biochim Biophys Sin (Shanghai); 2012 Aug 11; 44(8):685-91. PubMed ID: 22843172
    [Abstract] [Full Text] [Related]

  • 19. Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis.
    Wan C, Ma X, Shi S, Zhao J, Nie X, Han J, Xiao J, Wang X, Jiang S, Jiang J.
    Toxicol Appl Pharmacol; 2014 Dec 15; 281(3):294-302. PubMed ID: 25448048
    [Abstract] [Full Text] [Related]

  • 20. Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells.
    Kanno S, Kurauchi K, Tomizawa A, Yomogida S, Ishikawa M.
    Toxicol Lett; 2015 Jan 22; 232(2):393-402. PubMed ID: 25448278
    [Abstract] [Full Text] [Related]

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