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Journal Abstract Search

209 related items for PubMed ID: 32244978

  • 1. Sexually Dimorphic Behavioral Profile in a Transgenic Model Enabling Targeted Recombination in Active Neurons in Response to Ketamine and (2R,6R)-Hydroxynorketamine Administration.
    Herzog DP, Mellema RM, Remmers F, Lutz B, Müller MB, Treccani G.
    Int J Mol Sci; 2020 Mar 20; 21(6):. PubMed ID: 32244978
    [Abstract] [Full Text] [Related]

  • 2. Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine.
    Fukumoto K, Fogaça MV, Liu RJ, Duman C, Kato T, Li XY, Duman RS.
    Proc Natl Acad Sci U S A; 2019 Jan 02; 116(1):297-302. PubMed ID: 30559184
    [Abstract] [Full Text] [Related]

  • 3. BDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model.
    Ju L, Yang J, Zhu T, Liu P, Yang J.
    BMC Psychiatry; 2022 Mar 15; 22(1):182. PubMed ID: 35291971
    [Abstract] [Full Text] [Related]

  • 4. Brain-derived neurotrophic factor in the ventrolateral periaqueductal gray contributes to (2R,6R)-hydroxynorketamine-mediated actions.
    Chou D.
    Neuropharmacology; 2020 Jun 15; 170():108068. PubMed ID: 32222405
    [Abstract] [Full Text] [Related]

  • 5. Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function.
    Lumsden EW, Troppoli TA, Myers SJ, Zanos P, Aracava Y, Kehr J, Lovett J, Kim S, Wang FH, Schmidt S, Jenne CE, Yuan P, Morris PJ, Thomas CJ, Zarate CA, Moaddel R, Traynelis SF, Pereira EFR, Thompson SM, Albuquerque EX, Gould TD.
    Proc Natl Acad Sci U S A; 2019 Mar 12; 116(11):5160-5169. PubMed ID: 30796190
    [Abstract] [Full Text] [Related]

  • 6. A Pharmacological Evaluation of the Analgesic Effect and Hippocampal Protein Modulation of the Ketamine Metabolite (2R,6R)-Hydroxynorketamine in Murine Pain Models.
    Das V, Basovich MB, Thomas CJ, Kroin JS, Buvanendran A, McCarthy RJ.
    Anesth Analg; 2024 May 01; 138(5):1094-1106. PubMed ID: 37319016
    [Abstract] [Full Text] [Related]

  • 7. Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine.
    Highland JN, Morris PJ, Zanos P, Lovett J, Ghosh S, Wang AQ, Zarate CA, Thomas CJ, Moaddel R, Gould TD.
    J Psychopharmacol; 2019 Jan 01; 33(1):12-24. PubMed ID: 30488740
    [Abstract] [Full Text] [Related]

  • 8. Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine.
    Chen BK, Luna VM, LaGamma CT, Xu X, Deng SX, Suckow RF, Cooper TB, Shah A, Brachman RA, Mendez-David I, David DJ, Gardier AM, Landry DW, Denny CA.
    Neuropsychopharmacology; 2020 Aug 01; 45(9):1545-1556. PubMed ID: 32417852
    [Abstract] [Full Text] [Related]

  • 9. (2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions.
    Zanos P, Highland JN, Stewart BW, Georgiou P, Jenne CE, Lovett J, Morris PJ, Thomas CJ, Moaddel R, Zarate CA, Gould TD.
    Proc Natl Acad Sci U S A; 2019 Mar 26; 116(13):6441-6450. PubMed ID: 30867285
    [Abstract] [Full Text] [Related]

  • 10. Ketamine metabolite (2R,6R)-hydroxynorketamine reverses behavioral despair produced by adolescent trauma.
    Elmer GI, Tapocik JD, Mayo CL, Zanos P, Gould TD.
    Pharmacol Biochem Behav; 2020 Sep 26; 196():172973. PubMed ID: 32569786
    [Abstract] [Full Text] [Related]

  • 11. Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans.
    Highland JN, Farmer CA, Zanos P, Lovett J, Zarate CA, Moaddel R, Gould TD.
    J Psychopharmacol; 2022 Feb 26; 36(2):170-182. PubMed ID: 34971525
    [Abstract] [Full Text] [Related]

  • 12. cAMP-dependent protein kinase signaling is required for (2R,6R)-hydroxynorketamine to potentiate hippocampal glutamatergic transmission.
    Riggs LM, Pereira EFR, Thompson SM, Gould TD.
    J Neurophysiol; 2024 Jan 01; 131(1):64-74. PubMed ID: 38050689
    [Abstract] [Full Text] [Related]

  • 13. (2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
    Chou D, Peng HY, Lin TB, Lai CY, Hsieh MC, Wen YC, Lee AS, Wang HH, Yang PS, Chen GD, Ho YC.
    Neuropharmacology; 2018 Sep 01; 139():1-12. PubMed ID: 29953886
    [Abstract] [Full Text] [Related]

  • 14. (S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.
    Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Naito M, Yamaguchi T, Chen L, Kasai A, Seiriki K, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H, Ago Y.
    Pharmacol Biochem Behav; 2020 Apr 01; 191():172876. PubMed ID: 32088360
    [Abstract] [Full Text] [Related]

  • 15. Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine.
    Shaffer CL, Dutra JK, Tseng WC, Weber ML, Bogart LJ, Hales K, Pang J, Volfson D, Am Ende CW, Green ME, Buhl DL.
    Neuropharmacology; 2019 Jul 15; 153():73-81. PubMed ID: 31015046
    [Abstract] [Full Text] [Related]

  • 16. Efficacy of the ketamine metabolite (2R,6R)-hydroxynorketamine in mice models of pain.
    Kroin JS, Das V, Moric M, Buvanendran A.
    Reg Anesth Pain Med; 2019 Jan 15; 44(1):111-117. PubMed ID: 30640662
    [Abstract] [Full Text] [Related]

  • 17. (R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.
    Zanos P, Highland JN, Liu X, Troppoli TA, Georgiou P, Lovett J, Morris PJ, Stewart BW, Thomas CJ, Thompson SM, Moaddel R, Gould TD.
    Br J Pharmacol; 2019 Jul 15; 176(14):2573-2592. PubMed ID: 30941749
    [Abstract] [Full Text] [Related]

  • 18. Lack of metabolism in (R)-ketamine's antidepressant actions in a chronic social defeat stress model.
    Zhang K, Fujita Y, Hashimoto K.
    Sci Rep; 2018 Mar 05; 8(1):4007. PubMed ID: 29507385
    [Abstract] [Full Text] [Related]

  • 19. Antinociceptive and Analgesic Effects of (2R,6R)-Hydroxynorketamine.
    Yost JG, Wulf HA, Browne CA, Lucki I.
    J Pharmacol Exp Ther; 2022 Sep 05; 382(3):256-265. PubMed ID: 35779947
    [Abstract] [Full Text] [Related]

  • 20. Effects of subanesthetic ketamine and (2R,6R) hydroxynorketamine on working memory and synaptic transmission in the nucleus reuniens in mice.
    Goswamee P, Rice R, Leggett E, Zhang F, Manicka S, Porter JH, McQuiston AR.
    Neuropharmacology; 2022 May 01; 208():108965. PubMed ID: 35065945
    [Abstract] [Full Text] [Related]

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