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Journal Abstract Search
196 related items for PubMed ID: 32302123
1. First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. Cinelli MA, Reidl CT, Li H, Chreifi G, Poulos TL, Silverman RB. J Med Chem; 2020 May 14; 63(9):4528-4554. PubMed ID: 32302123 [Abstract] [Full Text] [Related]
2. Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB. J Med Chem; 2015 Nov 12; 58(21):8694-712. PubMed ID: 26469213 [Abstract] [Full Text] [Related]
3. Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. Pensa AV, Cinelli MA, Li H, Chreifi G, Mukherjee P, Roman LJ, Martásek P, Poulos TL, Silverman RB. J Med Chem; 2017 Aug 24; 60(16):7146-7165. PubMed ID: 28776992 [Abstract] [Full Text] [Related]
4. Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB. J Med Chem; 2017 May 11; 60(9):3958-3978. PubMed ID: 28422508 [Abstract] [Full Text] [Related]
5. Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition. Cinelli MA, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. J Med Chem; 2014 Feb 27; 57(4):1513-30. PubMed ID: 24472039 [Abstract] [Full Text] [Related]
6. Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase. Li H, Wang HY, Kang S, Silverman RB, Poulos TL. Biochemistry; 2016 Jul 05; 55(26):3702-7. PubMed ID: 27250740 [Abstract] [Full Text] [Related]
7. Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Flinspach ML, Li H, Jamal J, Yang W, Huang H, Hah JM, Gómez-Vidal JA, Litzinger EA, Silverman RB, Poulos TL. Nat Struct Mol Biol; 2004 Jan 05; 11(1):54-9. PubMed ID: 14718923 [Abstract] [Full Text] [Related]
8. Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase. Xue F, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. Bioorg Med Chem Lett; 2010 Nov 01; 20(21):6258-61. PubMed ID: 20833542 [Abstract] [Full Text] [Related]
9. Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors. Jing Q, Li H, Chreifi G, Roman LJ, Martásek P, Poulos TL, Silverman RB. Bioorg Med Chem Lett; 2013 Oct 15; 23(20):5674-9. PubMed ID: 23993333 [Abstract] [Full Text] [Related]
10. L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors. Fang J, Ji H, Lawton GR, Xue F, Roman LJ, Silverman RB. J Med Chem; 2009 Jul 23; 52(14):4533-7. PubMed ID: 19537690 [Abstract] [Full Text] [Related]
11. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Hah JM, Martásek P, Roman LJ, Silverman RB. J Med Chem; 2003 Apr 24; 46(9):1661-9. PubMed ID: 12699384 [Abstract] [Full Text] [Related]
13. Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors. Igarashi J, Li H, Jamal J, Ji H, Fang J, Lawton GR, Silverman RB, Poulos TL. J Med Chem; 2009 Apr 09; 52(7):2060-6. PubMed ID: 19296678 [Abstract] [Full Text] [Related]
14. Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker. Wang HY, Qin Y, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. J Med Chem; 2016 May 26; 59(10):4913-25. PubMed ID: 27050842 [Abstract] [Full Text] [Related]
15. Screening of novel and selective inhibitors for neuronal nitric oxide synthase (nNOS) via structure-based drug design techniques. Boumezber S, Yelekçi K. J Biomol Struct Dyn; 2023 May 26; 41(8):3607-3629. PubMed ID: 35322764 [Abstract] [Full Text] [Related]
16. In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures. Jing Q, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. Bioorg Med Chem; 2013 Sep 01; 21(17):5323-31. PubMed ID: 23867386 [Abstract] [Full Text] [Related]
17. 2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. Kang S, Li H, Tang W, Martásek P, Roman LJ, Poulos TL, Silverman RB. J Med Chem; 2015 Jul 23; 58(14):5548-60. PubMed ID: 26120733 [Abstract] [Full Text] [Related]