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Journal Abstract Search

164 related items for PubMed ID: 32437779

  • 21. Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac †.
    Yadav AS, Shah NR, Carlson TJ, Driscoll JP.
    Chem Res Toxicol; 2020 Jan 21; 33(1):249-257. PubMed ID: 31815452
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  • 22. Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.
    den Braver MW, den Braver-Sewradj SP, Vermeulen NP, Commandeur JN.
    Toxicol Lett; 2016 Jun 24; 253():46-54. PubMed ID: 27130197
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  • 23. Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice.
    Wang S, Bott D, Tung A, Sugamori KS, Grant DM.
    Drug Metab Dispos; 2015 Jul 24; 43(7):916-21. PubMed ID: 25922528
    [Abstract] [Full Text] [Related]

  • 24. Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
    Herraiz T, Guillén H, Arán VJ, Idle JR, Gonzalez FJ.
    Toxicol Appl Pharmacol; 2006 Nov 01; 216(3):387-98. PubMed ID: 16870220
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  • 25. Metabolism of sudoxicam by the rat, dog, and monkey.
    Hobbs DC, Twomey TM.
    Drug Metab Dispos; 1977 Nov 01; 5(1):75-81. PubMed ID: 13979
    [Abstract] [Full Text] [Related]

  • 26. A review of the clinical pharmacokinetics of meloxicam.
    Türck D, Roth W, Busch U.
    Br J Rheumatol; 1996 Apr 01; 35 Suppl 1():13-6. PubMed ID: 8630630
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  • 27. Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats.
    Punt A, Paini A, Boersma MG, Freidig AP, Delatour T, Scholz G, Schilter B, van Bladeren PJ, Rietjens IM.
    Toxicol Sci; 2009 Aug 01; 110(2):255-69. PubMed ID: 19447879
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  • 28. Investigation of the role of the 2',3'-epoxidation pathway in the bioactivation and genotoxicity of dietary allylbenzene analogs.
    Guenthner TM, Luo G.
    Toxicology; 2001 Mar 07; 160(1-3):47-58. PubMed ID: 11246123
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  • 29. Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients.
    Xie C, Zhou J, Guo Z, Diao X, Gao Z, Zhong D, Jiang H, Zhang L, Chen X.
    Br J Pharmacol; 2013 Apr 07; 168(7):1687-706. PubMed ID: 23126373
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  • 30. A comparative in vitro kinetic study of [14C]-eugenol and [14C]-methyleugenol activation and detoxification in human, mouse, and rat liver and lung fractions.
    Minet EF, Daniela G, Meredith C, Massey ED.
    Xenobiotica; 2012 May 07; 42(5):429-41. PubMed ID: 22188410
    [Abstract] [Full Text] [Related]

  • 31. Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.
    Subramanian R, Lee MR, Allen JG, Bourbeau MP, Fotsch C, Hong FT, Tadesse S, Yao G, Yuan CC, Surapaneni S, Skiles GL, Wang X, Wohlhieter GE, Zeng Q, Zhou Y, Zhu X, Li C.
    Chem Res Toxicol; 2010 Mar 15; 23(3):653-63. PubMed ID: 20095585
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  • 32. Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.
    Gómez-Lechón MJ, Tolosa L, Donato MT.
    J Appl Toxicol; 2016 Jun 15; 36(6):752-68. PubMed ID: 26691983
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  • 33. Modeling the Bioactivation and Subsequent Reactivity of Drugs.
    Hughes TB, Flynn N, Dang NL, Swamidass SJ.
    Chem Res Toxicol; 2021 Feb 15; 34(2):584-600. PubMed ID: 33496184
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  • 34. Biotransformation of NSAIDs by pig liver microsomes in vitro: Kinetics, metabolites identification and toxicity prediction.
    Ma L, Mao X, Sun X, Xu L.
    Chemosphere; 2017 Nov 15; 186():466-474. PubMed ID: 28806675
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  • 35. Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.
    Jeurissen SM, Bogaards JJ, Boersma MG, ter Horst JP, Awad HM, Fiamegos YC, van Beek TA, Alink GM, Sudhölter EJ, Cnubben NH, Rietjens IM.
    Chem Res Toxicol; 2006 Jan 15; 19(1):111-6. PubMed ID: 16411663
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  • 36. Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1.
    Wang K, Guengerich FP.
    Chem Res Toxicol; 2012 Aug 20; 25(8):1740-51. PubMed ID: 22734839
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  • 37. Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.
    Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ.
    J Biol Chem; 2014 Mar 07; 289(10):6799-6808. PubMed ID: 24425867
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  • 38. Metabolic N-hydroxylation. Use of substituent variation to modulate the in vitro bioactivation of 4-acetamidostilbenes.
    Hanna PE, Gammans RE, Sehon RD, Lee MK.
    J Med Chem; 1980 Sep 07; 23(9):1038-44. PubMed ID: 7411547
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  • 39. Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac.
    Chan TS, Yu H, Moore A, Khetani SR, Tweedie D.
    Drug Metab Dispos; 2013 Dec 07; 41(12):2024-32. PubMed ID: 23959596
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  • 40. Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
    Jaw S, Jeffery EH.
    Biochem Pharmacol; 1993 Aug 03; 46(3):493-501. PubMed ID: 8347173
    [Abstract] [Full Text] [Related]

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