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204 related items for PubMed ID: 32454005

  • 1. Synthesis and in vitro evaluation of novel non-oximes for the reactivation of nerve agent inhibited human acetylcholinesterase.
    de Koning MC, Horn G, Worek F, van Grol M.
    Chem Biol Interact; 2020 Aug 01; 326():109139. PubMed ID: 32454005
    [Abstract] [Full Text] [Related]

  • 2. Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase.
    de Koning MC, Horn G, Worek F, van Grol M.
    Eur J Med Chem; 2018 Sep 05; 157():151-160. PubMed ID: 30096649
    [Abstract] [Full Text] [Related]

  • 3. Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE.
    Kuca K, Hrabinova M, Jun D, Musilek K, Penhaker M, Krejcar O, Soukup O.
    Med Chem; 2015 Sep 05; 11(7):683-6. PubMed ID: 25845909
    [Abstract] [Full Text] [Related]

  • 4. Evaluation of nine oximes on in vivo reactivation of blood, brain, and tissue cholinesterase activity inhibited by organophosphorus nerve agents at lethal dose.
    Shih TM, Skovira JW, O'Donnell JC, McDonough JH.
    Toxicol Mech Methods; 2009 Sep 05; 19(6-7):386-400. PubMed ID: 19778239
    [Abstract] [Full Text] [Related]

  • 5. A comparison of the potency of the oxime HLö-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.
    Kuca K, Cabal J, Kassa J, Jun D, Hrabinová M.
    Acta Medica (Hradec Kralove); 2005 Sep 05; 48(2):81-6. PubMed ID: 16259317
    [Abstract] [Full Text] [Related]

  • 6. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents.
    Cadieux CL, Wang H, Zhang Y, Koenig JA, Shih TM, McDonough J, Koh J, Cerasoli D.
    Chem Biol Interact; 2016 Nov 25; 259(Pt B):133-141. PubMed ID: 27062893
    [Abstract] [Full Text] [Related]

  • 7. A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.
    Kuca K, Cabal J, Kassa J.
    Pharmazie; 2004 Oct 25; 59(10):795-8. PubMed ID: 15544060
    [Abstract] [Full Text] [Related]

  • 8. Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents.
    Giacoppo JO, C C França T, Kuča K, da Cunha EF, Abagyan R, Mancini DT, Ramalho TC.
    J Biomol Struct Dyn; 2015 Sep 25; 33(9):2048-58. PubMed ID: 25407587
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis and evaluation of novel nonquaternary and 3 non-oxime reactivators for acetylcholinesterase inhibited by organophosphates.
    Bi H, Ouyang Q, Wei Z, Zheng Z.
    Bioorg Chem; 2020 Jul 25; 100():103902. PubMed ID: 32388435
    [Abstract] [Full Text] [Related]

  • 10. Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase.
    Scheffel C, Thiermann H, Worek F.
    Toxicol Lett; 2015 Feb 03; 232(3):557-65. PubMed ID: 25522658
    [Abstract] [Full Text] [Related]

  • 11. Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.
    Zorbaz T, Malinak D, Maraković N, Maček Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M, Soukup O, Katalinić M, Kuca K, Kovarik Z, Musilek K.
    J Med Chem; 2018 Dec 13; 61(23):10753-10766. PubMed ID: 30383374
    [Abstract] [Full Text] [Related]

  • 12. A comparison of the ability of a new bispyridinium oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.
    Kuca K, Kassa J.
    J Enzyme Inhib Med Chem; 2003 Dec 13; 18(6):529-35. PubMed ID: 15008517
    [Abstract] [Full Text] [Related]

  • 13. Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro.
    Horn G, de Koning MC, van Grol M, Thiermann H, Worek F.
    Toxicol Lett; 2018 Dec 15; 299():218-225. PubMed ID: 30312685
    [Abstract] [Full Text] [Related]

  • 14. Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents.
    Zorbaz T, Malinak D, Hofmanova T, Maraković N, Žunec S, Hrvat NM, Andrys R, Psotka M, Zandona A, Svobodova J, Prchal L, Fingler S, Katalinić M, Kovarik Z, Musilek K.
    Eur J Med Chem; 2022 Aug 05; 238():114377. PubMed ID: 35526478
    [Abstract] [Full Text] [Related]

  • 15. Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX).
    Musílek K, Kuca K, Jun D.
    Acta Medica (Hradec Kralove); 2007 Aug 05; 50(3):203-6. PubMed ID: 18254274
    [Abstract] [Full Text] [Related]

  • 16. Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes.
    Zorbaz T, Malinak D, Kuca K, Musilek K, Kovarik Z.
    Chem Biol Interact; 2019 Jul 01; 307():16-20. PubMed ID: 31004594
    [Abstract] [Full Text] [Related]

  • 17. Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase.
    Sahu AK, Sharma R, Gupta B, Musilek K, Kuca K, Acharya J, Ghosh KK.
    Toxicol Mech Methods; 2016 Jun 01; 26(5):319-26. PubMed ID: 27101948
    [Abstract] [Full Text] [Related]

  • 18. In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
    Kuca K, Cabal J, Kassa J, Jun D, Hrabinova M.
    J Toxicol Environ Health A; 2006 Aug 01; 69(15):1431-40. PubMed ID: 16766478
    [Abstract] [Full Text] [Related]

  • 19. Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase.
    Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboléas M, Loiodice M, Weik M, Jean L, Renard PY, Nachon F, Baati R.
    Eur J Med Chem; 2014 May 06; 78():455-67. PubMed ID: 24704618
    [Abstract] [Full Text] [Related]

  • 20. Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study.
    Sharma R, Gupta B, Acharya J, Kaushik MP, Ghosh KK.
    Toxicology; 2014 Feb 28; 316():1-8. PubMed ID: 24345352
    [Abstract] [Full Text] [Related]

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