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193 related items for PubMed ID: 32493769

  • 1. Suramin and NF449 are IP5K inhibitors that disrupt inositol hexakisphosphate-mediated regulation of cullin-RING ligase and sensitize cancer cells to MLN4924/pevonedistat.
    Zhang X, Shi S, Su Y, Yang X, He S, Yang X, Wu J, Zhang J, Rao F.
    J Biol Chem; 2020 Jul 24; 295(30):10281-10292. PubMed ID: 32493769
    [Abstract] [Full Text] [Related]

  • 2. Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.
    Scherer PC, Ding Y, Liu Z, Xu J, Mao H, Barrow JC, Wei N, Zheng N, Snyder SH, Rao F.
    Proc Natl Acad Sci U S A; 2016 Mar 29; 113(13):3503-8. PubMed ID: 26976604
    [Abstract] [Full Text] [Related]

  • 3. Are Inositol Polyphosphates the Missing Link in Dynamic Cullin RING Ligase Regulation by the COP9 Signalosome?
    Zhang X, Rao F.
    Biomolecules; 2019 Aug 07; 9(8):. PubMed ID: 31394817
    [Abstract] [Full Text] [Related]

  • 4. Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells.
    Luo Z, Pan Y, Jeong LS, Liu J, Jia L.
    Autophagy; 2012 Nov 07; 8(11):1677-9. PubMed ID: 22874562
    [Abstract] [Full Text] [Related]

  • 5. Cullin-RING Ligase Regulation by the COP9 Signalosome: Structural Mechanisms and New Physiologic Players.
    Rao F, Lin H, Su Y.
    Adv Exp Med Biol; 2020 Nov 07; 1217():47-60. PubMed ID: 31898221
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  • 7. Primate lentiviruses require Inositol hexakisphosphate (IP6) or inositol pentakisphosphate (IP5) for the production of viral particles.
    Ricana CL, Lyddon TD, Dick RA, Johnson MC.
    PLoS Pathog; 2020 Aug 07; 16(8):e1008646. PubMed ID: 32776974
    [Abstract] [Full Text] [Related]

  • 8. CBS9106-induced CRM1 degradation is mediated by cullin ring ligase activity and the neddylation pathway.
    Saito N, Sakakibara K, Sato T, Friedman JM, Kufe DW, VonHoff DD, Kawabe T.
    Mol Cancer Ther; 2014 Dec 07; 13(12):3013-23. PubMed ID: 25253782
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  • 10. Neddylation inhibition upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma.
    Zhou S, Zhao X, Yang Z, Yang R, Chen C, Zhao K, Wang W, Ma Y, Zhang Q, Wang X.
    Int J Cancer; 2019 Aug 01; 145(3):763-774. PubMed ID: 31044422
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  • 13. Destabilization of CDC6 upon DNA damage is dependent on neddylation but independent of Cullin E3 ligases.
    Tan CY, Hagen T.
    Int J Biochem Cell Biol; 2013 Jul 01; 45(7):1489-98. PubMed ID: 23597704
    [Abstract] [Full Text] [Related]

  • 14. A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification.
    Xu B, Deng Y, Bi R, Guo H, Shu C, Shah NK, Chang J, Liu G, Du Y, Wei W, Wang C.
    Cancer Chemother Pharmacol; 2018 Jun 01; 81(6):1083-1093. PubMed ID: 29667067
    [Abstract] [Full Text] [Related]

  • 15. IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.
    Lin H, Yan Y, Luo Y, So WY, Wei X, Zhang X, Yang X, Zhang J, Su Y, Yang X, Zhang B, Zhang K, Jiang N, Chow BKC, Han W, Wang F, Rao F.
    Nat Commun; 2021 Apr 28; 12(1):2461. PubMed ID: 33911083
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  • 17. Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells.
    Wang Y, Luo Z, Pan Y, Wang W, Zhou X, Jeong LS, Chu Y, Liu J, Jia L.
    Cancer Biol Ther; 2015 Apr 28; 16(3):420-9. PubMed ID: 25782162
    [Abstract] [Full Text] [Related]

  • 18. The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity.
    Suisse A, Békés M, Huang TT, Treisman JE.
    Fly (Austin); 2018 Apr 28; 12(2):118-126. PubMed ID: 29355077
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  • 19. Suppression of glioblastoma by targeting the overactivated protein neddylation pathway.
    Hua W, Li C, Yang Z, Li L, Jiang Y, Yu G, Zhu W, Liu Z, Duan S, Chu Y, Yang M, Zhang Y, Mao Y, Jia L.
    Neuro Oncol; 2015 Oct 28; 17(10):1333-43. PubMed ID: 25904638
    [Abstract] [Full Text] [Related]

  • 20. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
    Bennett EJ, Rush J, Gygi SP, Harper JW.
    Cell; 2010 Dec 10; 143(6):951-65. PubMed ID: 21145461
    [Abstract] [Full Text] [Related]

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