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244 related items for PubMed ID: 32563148

  • 1. Catalpol coordinately regulates phase I and II detoxification enzymes of Triptolide through CAR and NRF2 pathways to reduce Triptolide-induced hepatotoxicity.
    Fu L, Zhou L, Geng S, Li M, Lu W, Lu Y, Feng Z, Zhou X.
    Biomed Pharmacother; 2020 Sep; 129():110379. PubMed ID: 32563148
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  • 2. Catalpol and panax notoginseng saponins synergistically alleviate triptolide-induced hepatotoxicity through Nrf2/ARE pathway.
    Feng Z, Zhou C, Dong S, Liu Z, Liu T, Zhou L, Zhou X.
    Toxicol In Vitro; 2019 Apr; 56():141-149. PubMed ID: 30682494
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  • 3. Triptolide-induced hepatotoxicity can be alleviated when combined with Panax notoginseng saponins and Catapol.
    Zhou L, Zhou C, Feng Z, Liu Z, Zhu H, Zhou X.
    J Ethnopharmacol; 2018 Mar 25; 214():232-239. PubMed ID: 29277608
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  • 4. Role of MicroRNA-155 in Triptolide-induced hepatotoxicity via the Nrf2-Dependent pathway.
    Li Y, Guo L, Hou Z, Gong H, Yan M, Zhang B.
    J Ethnopharmacol; 2021 Dec 05; 281():114489. PubMed ID: 34363931
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  • 5. Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway.
    Zhou Y, Xia L, Yao W, Han J, Wang G.
    Biomed Res Int; 2020 Dec 05; 2020():2508952. PubMed ID: 33123566
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  • 6. Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.
    Du F, Liu Z, Li X, Xing J.
    J Appl Toxicol; 2014 Aug 05; 34(8):878-84. PubMed ID: 23836259
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  • 8. Triptolide and atorvastatin synergistically promote hepatotoxicity in cultured hepatocytes and female Sprague-Dawley rats by inhibiting pregnane X receptor-mediated transcriptional activation of CYP3A4.
    Zheng N, Wei A, Wu T, Long L, Yang H, Li H, Wang L.
    Toxicol Lett; 2021 May 15; 342():85-94. PubMed ID: 33600922
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  • 11. Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes.
    Lu Y, Xie T, Zhang Y, Zhou F, Ruan J, Zhu W, Zhu H, Feng Z, Zhou X.
    BMC Complement Altern Med; 2017 Jan 05; 17(1):15. PubMed ID: 28056947
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  • 12. Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes.
    Shen G, Zhuang X, Xiao W, Kong L, Tan Y, Li H.
    Food Chem Toxicol; 2014 Sep 05; 71():90-6. PubMed ID: 24910460
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  • 13. Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice.
    Aleksunes LM, Klaassen CD.
    Drug Metab Dispos; 2012 Jul 05; 40(7):1366-79. PubMed ID: 22496397
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  • 14. Isoliquiritigenin protects against triptolide-induced hepatotoxicity in mice through Nrf2 activation.
    Cao L-, Yan M, Ma YX, Zhang BK, Fang PF, Xiang DX, Li ZH, Gong H, Deng Y, Li HD.
    Pharmazie; 2016 Jul 07; 71(7):394-397. PubMed ID: 29441915
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  • 18. Catalpol attenuates hepatic glucose metabolism disorder and oxidative stress in triptolide-induced liver injury by regulating the SIRT1/HIF-1α pathway.
    Nie W, Zhu H, Sun X, Zhou J, Xu H, Yu Z, Lu M, Jiang B, Zhou L, Zhou X.
    Int J Biol Sci; 2024 Jul 07; 20(10):4077-4097. PubMed ID: 39113710
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  • 19. Novel detoxifier of spironolactone against triptolide-induced hepatotoxicity through inhibition of RPB1 degradation.
    Qiang L, Lee SH, Xiao P, Chunhui L, Lei G, Shaoli C, Tingjie Y, Guangli D, Wei X, Guofu Z.
    J Ethnopharmacol; 2025 Jan 10; 336():118722. PubMed ID: 39182704
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  • 20. Phenanthrene, but not its isomer anthracene, effectively activates both human and mouse nuclear receptor constitutive androstane receptor (CAR) and induces hepatotoxicity in mice.
    Yang H, Shi Z, Wang XX, Cheng R, Lu M, Zhu J, Deng W, Zeng Y, Zhao LY, Zhang SY.
    Toxicol Appl Pharmacol; 2019 Sep 01; 378():114618. PubMed ID: 31181217
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