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Journal Abstract Search

227 related items for PubMed ID: 3258018

  • 1. Potent neurotoxic fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs as potential probes in models of Parkinson disease.
    Riachi NJ, Arora PK, Sayre LM, Harik SI.
    J Neurochem; 1988 Apr; 50(4):1319-21. PubMed ID: 3258018
    [Abstract] [Full Text] [Related]

  • 2. Development of fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs with potent nigrostriatal toxicity for potential use in positron emission tomography studies.
    Harik SI, Riachi NJ, Hritz MA, Berridge MS, Sayre LM.
    J Pharmacol Exp Ther; 1993 Aug; 266(2):790-5. PubMed ID: 8355208
    [Abstract] [Full Text] [Related]

  • 3. Evaluation of the biological activity of several analogs of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    Youngster SK, Sonsalla PK, Heikkila RE.
    J Neurochem; 1987 Mar; 48(3):929-34. PubMed ID: 3492590
    [Abstract] [Full Text] [Related]

  • 4. Structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. I. Evaluation of the biological activity of MPTP analogs.
    Youngster SK, Sonsalla PK, Sieber BA, Heikkila RE.
    J Pharmacol Exp Ther; 1989 Jun; 249(3):820-8. PubMed ID: 2786564
    [Abstract] [Full Text] [Related]

  • 5. Structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. II. Evaluation of the biological activity of the pyridinium metabolites formed from the monoamine oxidase-catalyzed oxidation of MPTP analogs.
    Youngster SK, Nicklas WJ, Heikkila RE.
    J Pharmacol Exp Ther; 1989 Jun; 249(3):829-35. PubMed ID: 2786565
    [Abstract] [Full Text] [Related]

  • 6. Comparison of the effects of two 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs, 1-methyl-4-(2-thienyl)-1,2,3,6-tetrahydropyridine and 1-methyl-4-(3-thienyl)-1,2,3,6-tetrahydropyridine, on monoamine oxidase in vitro and on dopamine in mouse brain.
    Fuller RW, Robertson DW, Hemrick-Luecke SK.
    J Pharmacol Exp Ther; 1987 Feb; 240(2):415-20. PubMed ID: 3100775
    [Abstract] [Full Text] [Related]

  • 7. Role for monoamine oxidase-A (MAO-A) in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog, 2'Me-MPTP.
    Kindt MV, Youngster SK, Sonsalla PK, Duvoisin RC, Heikkila RE.
    Eur J Pharmacol; 1988 Feb 09; 146(2-3):313-8. PubMed ID: 3131149
    [Abstract] [Full Text] [Related]

  • 8. Strain differences in systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in mice correlate best with monoamine oxidase activity at the blood-brain barrier.
    Riachi NJ, Harik SI.
    Life Sci; 1988 Feb 09; 42(23):2359-63. PubMed ID: 3259663
    [Abstract] [Full Text] [Related]

  • 9. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in the mouse: relationships between monoamine oxidase, MPTP metabolism and neurotoxicity.
    Heikkila RE, Hess A, Duvoisin RC.
    Life Sci; 1985 Jan 21; 36(3):231-6. PubMed ID: 3917525
    [Abstract] [Full Text] [Related]

  • 10. Ro 16-6491: a new reversible and highly selective MAO-B inhibitor protects mice from the dopaminergic neurotoxicity of MPTP.
    Da Prada M, Kettler R, Keller HH, Bonetti EP, Imhof R.
    Adv Neurol; 1987 Jan 21; 45():175-8. PubMed ID: 2881442
    [No Abstract] [Full Text] [Related]

  • 11. Prevention of dopaminergic toxicity of MPTP in mice by phenylethylamine, a specific substrate of type B monoamine oxidase.
    Melamed E, Youdim MB.
    Br J Pharmacol; 1985 Nov 21; 86(3):529-31. PubMed ID: 3877535
    [Abstract] [Full Text] [Related]

  • 12. The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease.
    Jenner P, Marsden CD.
    J Neural Transm Suppl; 1986 Nov 21; 20():11-39. PubMed ID: 3091760
    [Abstract] [Full Text] [Related]

  • 13. Studies on the oxidation of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase B.
    Heikkila RE, Manzino L, Cabbat FS, Duvoisin RC.
    J Neurochem; 1985 Oct 21; 45(4):1049-54. PubMed ID: 3928814
    [Abstract] [Full Text] [Related]

  • 14. 1,2,3,6-tetrahydro-1-methyl-4-(methylpyrrol-2-yl)pyridine: studies on the mechanism of action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    Finnegan KT, Irwin I, Delanney LE, Ricaurte GA, Langston JW.
    J Pharmacol Exp Ther; 1987 Sep 21; 242(3):1144-51. PubMed ID: 3498815
    [Abstract] [Full Text] [Related]

  • 15. On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: the effect of perinigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, its metabolite and their analogs in the rat.
    Harik SI, Schmidley JW, Iacofano LA, Blue P, Arora PK, Sayre LM.
    J Pharmacol Exp Ther; 1987 May 21; 241(2):669-76. PubMed ID: 2437293
    [Abstract] [Full Text] [Related]

  • 16. Characterization of the neurotoxic potential of m-methoxy-MPTP and the use of its N-ethyl analogue as a means of avoiding exposure to a possible Parkinsonism-causing agent.
    Zimmerman DM, Cantrell BE, Reel JK, Hemrick-Luecke SK, Fuller RW.
    J Med Chem; 1986 Aug 21; 29(8):1517-20. PubMed ID: 3488406
    [Abstract] [Full Text] [Related]

  • 17. Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity.
    Kalaria RN, Mitchell MJ, Harik SI.
    Proc Natl Acad Sci U S A; 1987 May 21; 84(10):3521-5. PubMed ID: 3495000
    [Abstract] [Full Text] [Related]

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  • 19. Studies on the 1-methyl-4-phenyl-2,3-dihydropyridinium species 2,3-MPDP+, the monoamine oxidase catalyzed oxidation product of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
    Peterson LA, Caldera PS, Trevor A, Chiba K, Castagnoli N.
    J Med Chem; 1985 Oct 21; 28(10):1432-6. PubMed ID: 3876442
    [Abstract] [Full Text] [Related]

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