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Journal Abstract Search

575 related items for PubMed ID: 32650183

  • 1. Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.
    Li G, Wang Y, Li L, Ren Y, Deng X, Liu J, Wang W, Luo M, Liu S, Chen J.
    Eur J Med Chem; 2020 Sep 15; 202():112519. PubMed ID: 32650183
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis and bioevaluation of 2,7-diaryl-pyrazolo[1,5-a]pyrimidines as tubulin polymerization inhibitors.
    Liu R, Zhang S, Huang M, Guo Z, Li L, Li M, Wu L, Guan Q, Zhang W.
    Bioorg Chem; 2021 Oct 15; 115():105220. PubMed ID: 34352709
    [Abstract] [Full Text] [Related]

  • 3. Design and discovery of new antiproliferative 1,2,4-triazin-3(2H)-ones as tubulin polymerization inhibitors targeting colchicine binding site.
    Eissa IH, Dahab MA, Ibrahim MK, Alsaif NA, Alanazi AZ, Eissa SI, Mehany ABM, Beauchemin AM.
    Bioorg Chem; 2021 Jul 15; 112():104965. PubMed ID: 34020238
    [Abstract] [Full Text] [Related]

  • 4. Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
    Liu YN, Wang JJ, Ji YT, Zhao GD, Tang LQ, Zhang CM, Guo XL, Liu ZP.
    J Med Chem; 2016 Jun 09; 59(11):5341-55. PubMed ID: 27172319
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and bioevaluation of N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amines as tubulin polymerization inhibitors with anti-angiogenic effects.
    Hao SY, Qi ZY, Wang S, Wang XR, Chen SW.
    Bioorg Med Chem; 2021 Feb 01; 31():115985. PubMed ID: 33421913
    [Abstract] [Full Text] [Related]

  • 6. Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance.
    Cheng B, Zhu G, Meng L, Wu G, Chen Q, Ma S.
    Eur J Med Chem; 2022 Jan 15; 228():113930. PubMed ID: 34794817
    [Abstract] [Full Text] [Related]

  • 7. Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities.
    Yang F, Yu LZ, Diao PC, Jian XE, Zhou MF, Jiang CS, You WW, Ma WF, Zhao PL.
    Bioorg Chem; 2019 Nov 15; 92():103260. PubMed ID: 31525523
    [Abstract] [Full Text] [Related]

  • 8. Discovery of novel thiophene[3,2-d]pyrimidine-based tubulin inhibitors with enhanced antitumor efficacy for combined use with anti-pd-l1 immunotherapy in melanoma.
    Xu C, Wu C, Li L, Zhao H, Liu J, Peng X, Wang Y, Chen J.
    Eur J Med Chem; 2024 Nov 05; 277():116791. PubMed ID: 39197251
    [Abstract] [Full Text] [Related]

  • 9. The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo.
    Cui YJ, Ma CC, Zhang CM, Tang LQ, Liu ZP.
    Eur J Med Chem; 2020 Feb 01; 187():111968. PubMed ID: 31865012
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.
    Lai Q, Wang Y, Wang R, Lai W, Tang L, Tao Y, Liu Y, Zhang R, Huang L, Xiang H, Zeng S, Gou L, Chen H, Yao Y, Yang J.
    Eur J Med Chem; 2018 Aug 05; 156():162-179. PubMed ID: 30006162
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities.
    Ren Y, Ruan Y, Cheng B, Li L, Liu J, Fang Y, Chen J.
    Bioorg Med Chem; 2021 Sep 15; 46():116376. PubMed ID: 34455231
    [Abstract] [Full Text] [Related]

  • 12. Discovery of highly potent tubulin polymerization inhibitors: Design, synthesis, and structure-activity relationships of novel 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidines.
    Huo XS, Jian XE, Ou-Yang J, Chen L, Yang F, Lv DX, You WW, Rao JJ, Zhao PL.
    Eur J Med Chem; 2021 Aug 05; 220():113449. PubMed ID: 33895499
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis and biological evaluation of benz-fused five-membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities.
    Komuraiah B, Ren Y, Xue M, Cheng B, Liu J, Liu Y, Chen J.
    Chem Biol Drug Des; 2021 May 05; 97(5):1109-1116. PubMed ID: 33638903
    [Abstract] [Full Text] [Related]

  • 14. 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.
    Romagnoli R, Kimatrai Salvador M, Schiaffino Ortega S, Baraldi PG, Oliva P, Baraldi S, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Balzarini J, Liekens S, Mattiuzzo E, Basso G, Viola G.
    Eur J Med Chem; 2018 Jan 01; 143():683-698. PubMed ID: 29220790
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and evaluation of new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives as tubulin polymerization inhibitors.
    Xu S, An B, Li Y, Luo X, Li X, Jia X.
    Bioorg Med Chem Lett; 2018 Jun 01; 28(10):1769-1775. PubMed ID: 29673981
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis and biological evaluation of colchicine glycoconjugates as tubulin polymerization inhibitors.
    Wang Z, Liu R, Zhang X, Chang X, Gao M, Zhang S, Guan Q, Sun J, Zuo D, Zhang W.
    Bioorg Med Chem; 2022 Mar 15; 58():116671. PubMed ID: 35193066
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors.
    Liu R, Huang M, Zhang S, Li L, Li M, Sun J, Wu L, Guan Q, Zhang W.
    Eur J Med Chem; 2021 Dec 15; 226():113826. PubMed ID: 34571171
    [Abstract] [Full Text] [Related]

  • 18. Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation.
    Hagras M, El Deeb MA, Elzahabi HSA, Elkaeed EB, Mehany ABM, Eissa IH.
    J Enzyme Inhib Med Chem; 2021 Dec 15; 36(1):640-658. PubMed ID: 33588683
    [Abstract] [Full Text] [Related]

  • 19. Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
    Wu C, Zhang L, Zhou Z, Tan L, Wang Z, Guo C, Wang Y.
    Eur J Med Chem; 2024 Oct 05; 276():116649. PubMed ID: 38972078
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities.
    Sun YX, Song J, Kong LJ, Sha BB, Tian XY, Liu XJ, Hu T, Chen P, Zhang SY.
    Eur J Med Chem; 2022 Feb 05; 229():114069. PubMed ID: 34971875
    [Abstract] [Full Text] [Related]

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