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161 related items for PubMed ID: 32735318

  • 1. Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice.
    Yamada T, Ohara A, Ozawa N, Maeda K, Kondo M, Okuda Y, Abe J, Cohen SM, Lake BG.
    Toxicol Sci; 2020 Oct 01; 177(2):362-376. PubMed ID: 32735318
    [Abstract] [Full Text] [Related]

  • 2. Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.
    Haines C, Elcombe BM, Chatham LR, Vardy A, Higgins LG, Elcombe CR, Lake BG.
    Toxicology; 2018 Mar 01; 396-397():23-32. PubMed ID: 29425889
    [Abstract] [Full Text] [Related]

  • 3. Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).
    Yamada T.
    J Toxicol Pathol; 2021 Oct 01; 34(4):283-297. PubMed ID: 34629731
    [Abstract] [Full Text] [Related]

  • 4. Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.
    Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG.
    Toxicol Sci; 2014 Jun 01; 139(2):501-11. PubMed ID: 24690595
    [Abstract] [Full Text] [Related]

  • 5. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
    Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.
    Toxicology; 2018 May 01; 400-401():20-27. PubMed ID: 29548889
    [Abstract] [Full Text] [Related]

  • 6. Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.
    Marx-Stoelting P, Ganzenberg K, Knebel C, Schmidt F, Rieke S, Hammer H, Schmidt F, Pötz O, Schwarz M, Braeuning A.
    Arch Toxicol; 2017 Aug 01; 91(8):2895-2907. PubMed ID: 28058446
    [Abstract] [Full Text] [Related]

  • 7. Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
    Ross J, Plummer SM, Rode A, Scheer N, Bower CC, Vogel O, Henderson CJ, Wolf CR, Elcombe CR.
    Toxicol Sci; 2010 Aug 01; 116(2):452-66. PubMed ID: 20403969
    [Abstract] [Full Text] [Related]

  • 8. Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor.
    Li L, Welch MA, Li Z, Mackowiak B, Heyward S, Swaan PW, Wang H.
    Mol Pharmacol; 2019 Sep 01; 96(3):345-354. PubMed ID: 31436536
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  • 11. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats.
    Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.
    Xenobiotica; 2019 Feb 01; 49(2):227-238. PubMed ID: 29424600
    [Abstract] [Full Text] [Related]

  • 12. Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).
    Yamada T, Cohen SM, Lake BG.
    Crit Rev Toxicol; 2021 May 01; 51(5):373-394. PubMed ID: 34264181
    [Abstract] [Full Text] [Related]

  • 13. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.
    Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H.
    J Pharmacol Exp Ther; 2007 Jan 01; 320(1):72-80. PubMed ID: 17041008
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  • 14. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.
    Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H.
    J Pharmacol Exp Ther; 2006 Jun 01; 317(3):1200-9. PubMed ID: 16513849
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  • 16. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.
    Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG.
    Crit Rev Toxicol; 2014 Jan 01; 44(1):64-82. PubMed ID: 24180433
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  • 17. Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance.
    Lake BG, Price RJ, Scott MP, Chatham LR, Vardy A, Osimitz TG.
    Toxicology; 2020 Jun 01; 439():152465. PubMed ID: 32320717
    [Abstract] [Full Text] [Related]

  • 18. Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor.
    Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TK.
    J Pharmacol Exp Ther; 2011 Mar 01; 336(3):816-26. PubMed ID: 21131266
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  • 19. Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.
    Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E.
    J Biol Chem; 2004 Jul 09; 279(28):29295-301. PubMed ID: 15123723
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  • 20. Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells.
    Li D, Mackowiak B, Brayman TG, Mitchell M, Zhang L, Huang SM, Wang H.
    Biochem Pharmacol; 2015 Nov 01; 98(1):190-202. PubMed ID: 26275810
    [Abstract] [Full Text] [Related]

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