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155 related items for PubMed ID: 33022479

  • 1. Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study.
    Ma W, Chen P, Huo X, Ma Y, Li Y, Diao P, Yang F, Zheng S, Hu M, You W, Zhao P.
    Eur J Med Chem; 2020 Dec 15; 208():112847. PubMed ID: 33022479
    [Abstract] [Full Text] [Related]

  • 2. Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.
    Li Y, Liu Y, Zhu Z, Yan W, Zhang C, Yang Z, Bai P, Tang M, Shi M, He W, Fu S, Liu J, Han K, Li J, Xie L, Ye H, Yang J, Chen L.
    J Med Chem; 2022 Feb 10; 65(3):2675-2693. PubMed ID: 35084853
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors.
    Xu Q, Bao K, Sun M, Xu J, Wang Y, Tian H, Zuo D, Guan Q, Wu Y, Zhang W.
    Sci Rep; 2017 Sep 20; 7(1):11997. PubMed ID: 28931885
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and biological evaluation of indole-based [1,2,4]triazolo[4,3-a] pyridine derivatives as novel microtubule polymerization inhibitors.
    Wu CJ, Wu JQ, Hu Y, Pu S, Lin Y, Zeng Z, Hu J, Chen WH.
    Eur J Med Chem; 2021 Nov 05; 223():113629. PubMed ID: 34175541
    [Abstract] [Full Text] [Related]

  • 5. Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
    Chen H, Deng S, Albadari N, Yun MK, Zhang S, Li Y, Ma D, Parke DN, Yang L, Seagroves TN, White SW, Miller DD, Li W.
    J Med Chem; 2021 Aug 26; 64(16):12049-12074. PubMed ID: 34378386
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors.
    Wang G, Peng F, Cao D, Yang Z, Han X, Liu J, Wu W, He L, Ma L, Chen J, Sang Y, Xiang M, Peng A, Wei Y, Chen L.
    Bioorg Med Chem; 2013 Nov 01; 21(21):6844-54. PubMed ID: 23993668
    [Abstract] [Full Text] [Related]

  • 7. Discovery of novel 6-p-tolyl-3-(3,4,5-trimethoxybenzyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivative as a potent tubulin inhibitor with promising in vivo antitumor activity.
    Ji T, Jian X, Chen L, Zeng W, Huo X, Li M, Chen P, Zhang Y, You W, Zhao P.
    Eur J Med Chem; 2023 Aug 05; 256():115437. PubMed ID: 37172475
    [Abstract] [Full Text] [Related]

  • 8. Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site.
    Li W, Sun H, Xu F, Shuai W, Liu J, Xu S, Yao H, Ma C, Zhu Z, Xu J.
    Bioorg Chem; 2019 Apr 05; 85():49-59. PubMed ID: 30599412
    [Abstract] [Full Text] [Related]

  • 9. Design and synthesis of imidazo[2,1-b]thiazole-chalcone conjugates: microtubule-destabilizing agents.
    Kamal A, Balakrishna M, Nayak VL, Shaik TB, Faazil S, Nimbarte VD.
    ChemMedChem; 2014 Dec 05; 9(12):2766-80. PubMed ID: 25313981
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and structure-activity relationships of 5-phenyloxazole-2-carboxylic acid derivatives as novel inhibitors of tubulin polymerization.
    Zhang R, Mo H, Ma YY, Zhao DG, Zhang K, Zhang T, Chen X, Zheng X.
    Bioorg Med Chem Lett; 2021 May 15; 40():127968. PubMed ID: 33753264
    [Abstract] [Full Text] [Related]

  • 11. Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities.
    Yang F, Yu LZ, Diao PC, Jian XE, Zhou MF, Jiang CS, You WW, Ma WF, Zhao PL.
    Bioorg Chem; 2019 Nov 15; 92():103260. PubMed ID: 31525523
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and biological evaluation of quinoxaline derivatives as tubulin polymerization inhibitors that elevate intracellular ROS and triggers apoptosis via mitochondrial pathway.
    Qi J, Huang J, Zhou X, Luo W, Xie J, Niu L, Yan Z, Luo Y, Men Y, Chen Y, Zhang Y, Wang J.
    Chem Biol Drug Des; 2019 Apr 15; 93(4):617-627. PubMed ID: 30635972
    [Abstract] [Full Text] [Related]

  • 13. 3-Aryl/Heteroaryl-5-amino-1-(3',4',5'-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization.
    Romagnoli R, Prencipe F, Oliva P, Baraldi S, Baraldi PG, Brancale A, Ferla S, Hamel E, Bortolozzi R, Viola G.
    Bioorg Chem; 2018 Oct 15; 80():361-374. PubMed ID: 29986184
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors.
    Abdelbaset MS, Abdelrahman MH, Bukhari SNA, Gouda AM, Youssif BGM, Abdel-Aziz M, Abuo-Rahma GEA.
    Bioorg Chem; 2021 Feb 15; 107():104522. PubMed ID: 33317838
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and biological evaluation of 1-benzyl-N-(2-(phenylamino)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamides as antimitotic agents.
    Prasad B, Lakshma Nayak V, Srikanth PS, Baig MF, Subba Reddy NV, Babu KS, Kamal A.
    Bioorg Chem; 2019 Mar 15; 83():535-548. PubMed ID: 30472555
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo.
    Pang Y, Lin H, Ou C, Cao Y, An B, Yan J, Li X.
    Eur J Med Chem; 2019 Nov 15; 182():111670. PubMed ID: 31499359
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors.
    Shuai W, Li X, Li W, Xu F, Lu L, Yao H, Yang L, Zhu H, Xu S, Zhu Z, Xu J.
    Eur J Med Chem; 2020 Jul 01; 197():112308. PubMed ID: 32339853
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis and biological evaluation of flexible and rigid analogs of 4H-1,2,4-triazoles bearing 3,4,5-trimethoxyphenyl moiety as new antiproliferative agents.
    Ansari M, Shokrzadeh M, Karima S, Rajaei S, Hashemi SM, Mirzaei H, Fallah M, Emami S.
    Bioorg Chem; 2019 Dec 01; 93():103300. PubMed ID: 31586708
    [Abstract] [Full Text] [Related]

  • 19. Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain.
    Li W, Yin Y, Shuai W, Xu F, Yao H, Liu J, Cheng K, Xu J, Zhu Z, Xu S.
    Bioorg Chem; 2019 Mar 01; 83():380-390. PubMed ID: 30408650
    [Abstract] [Full Text] [Related]

  • 20. DAT-230, a novel microtubule inhibitor, exhibits potent anti-tumor activity by inducing G2/M phase arrest, apoptosis in vitro and perfusion decrease in vivo to HT-1080.
    Qiao F, Zuo D, Shen X, Qi H, Wang H, Zhang W, Wu Y.
    Cancer Chemother Pharmacol; 2012 Aug 01; 70(2):259-70. PubMed ID: 22752214
    [Abstract] [Full Text] [Related]

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