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605 related items for PubMed ID: 33225946

  • 1. Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions.
    Kästle M, Merten C, Hartig R, Kaehne T, Liaunardy-Jopeace A, Woessner NM, Schamel WW, James J, Minguet S, Simeoni L, Schraven B.
    Cell Commun Signal; 2020 Nov 23; 18(1):183. PubMed ID: 33225946
    [Abstract] [Full Text] [Related]

  • 2. A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
    Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A.
    Mol Cell; 2017 Aug 03; 67(3):498-511.e6. PubMed ID: 28735895
    [Abstract] [Full Text] [Related]

  • 3. A weak Lck tail bite is necessary for Lck function in T cell antigen receptor signaling.
    Nika K, Tautz L, Arimura Y, Vang T, Williams S, Mustelin T.
    J Biol Chem; 2007 Dec 07; 282(49):36000-9. PubMed ID: 17897955
    [Abstract] [Full Text] [Related]

  • 4. TCR-induced T cell activation leads to simultaneous phosphorylation at Y505 and Y394 of p56(lck) residues.
    Nyakeriga AM, Garg H, Joshi A.
    Cytometry A; 2012 Sep 07; 81(9):797-805. PubMed ID: 22674786
    [Abstract] [Full Text] [Related]

  • 5. Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection.
    Kästle M, Merten C, Hartig R, Plaza-Sirvent C, Schmitz I, Bommhardt U, Schraven B, Simeoni L.
    Int J Mol Sci; 2022 Jun 30; 23(13):. PubMed ID: 35806279
    [Abstract] [Full Text] [Related]

  • 6. Expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation.
    Wang Y, Johnson P.
    J Biol Chem; 2005 Apr 08; 280(14):14318-24. PubMed ID: 15687496
    [Abstract] [Full Text] [Related]

  • 7. The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling.
    Denny MF, Kaufman HC, Chan AC, Straus DB.
    J Biol Chem; 1999 Feb 19; 274(8):5146-52. PubMed ID: 9988764
    [Abstract] [Full Text] [Related]

  • 8. CD45 down-regulates Lck-mediated CD44 signaling and modulates actin rearrangement in T cells.
    Wong NK, Lai JC, Birkenhead D, Shaw AS, Johnson P.
    J Immunol; 2008 Nov 15; 181(10):7033-43. PubMed ID: 18981123
    [Abstract] [Full Text] [Related]

  • 9. The role of competing mechanisms on Lck regulation.
    Bozso SJ, Kang JJH, Nagendran J.
    Immunol Res; 2020 Oct 15; 68(5):289-295. PubMed ID: 32794043
    [Abstract] [Full Text] [Related]

  • 10. Phospho-mimetic CD3ε variants prevent TCR and CAR signaling.
    Woessner NM, Brandl SM, Hartmann S, Schamel WW, Hartl FA, Minguet S.
    Front Immunol; 2024 Oct 15; 15():1392933. PubMed ID: 38779683
    [Abstract] [Full Text] [Related]

  • 11. The CD45 tyrosine phosphatase regulates CD3-induced signal transduction and T cell development in recombinase-deficient mice: restoration of pre-TCR function by active p56(lck).
    Pingel S, Baker M, Turner M, Holmes N, Alexander DR.
    Eur J Immunol; 1999 Aug 15; 29(8):2376-84. PubMed ID: 10458749
    [Abstract] [Full Text] [Related]

  • 12. T cell-specific adapter protein inhibits T cell activation by modulating Lck activity.
    Sundvold V, Torgersen KM, Post NH, Marti F, King PD, Røttingen JA, Spurkland A, Lea T.
    J Immunol; 2000 Sep 15; 165(6):2927-31. PubMed ID: 10975797
    [Abstract] [Full Text] [Related]

  • 13. De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.
    Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kästle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ.
    Sci Signal; 2017 Jan 17; 10(462):. PubMed ID: 28096507
    [Abstract] [Full Text] [Related]

  • 14. Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.
    Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A.
    Nat Immunol; 2018 Jul 17; 19(7):733-741. PubMed ID: 29915297
    [Abstract] [Full Text] [Related]

  • 15. Differential Src family kinase activity requirements for CD3 zeta phosphorylation/ZAP70 recruitment and CD3 epsilon phosphorylation.
    Lysechko TL, Ostergaard HL.
    J Immunol; 2005 Jun 15; 174(12):7807-14. PubMed ID: 15944285
    [Abstract] [Full Text] [Related]

  • 16. Differential regulation of CXCR4-mediated T-cell chemotaxis and mitogen-activated protein kinase activation by the membrane tyrosine phosphatase, CD45.
    Fernandis AZ, Cherla RP, Ganju RK.
    J Biol Chem; 2003 Mar 14; 278(11):9536-43. PubMed ID: 12519755
    [Abstract] [Full Text] [Related]

  • 17. Changes in the role of the CD45 protein tyrosine phosphatase in regulating Lck tyrosine phosphorylation during thymic development.
    Falahati R, Leitenberg D.
    J Immunol; 2007 Feb 15; 178(4):2056-64. PubMed ID: 17277109
    [Abstract] [Full Text] [Related]

  • 18. T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315.
    Gelkop S, Gish GD, Babichev Y, Pawson T, Isakov N.
    J Immunol; 2005 Dec 15; 175(12):8123-32. PubMed ID: 16339550
    [Abstract] [Full Text] [Related]

  • 19. Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction.
    Dornan S, Sebestyen Z, Gamble J, Nagy P, Bodnar A, Alldridge L, Doe S, Holmes N, Goff LK, Beverley P, Szollosi J, Alexander DR.
    J Biol Chem; 2002 Jan 18; 277(3):1912-8. PubMed ID: 11694532
    [Abstract] [Full Text] [Related]

  • 20. SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction.
    Straus DB, Chan AC, Patai B, Weiss A.
    J Biol Chem; 1996 Apr 26; 271(17):9976-81. PubMed ID: 8626636
    [Abstract] [Full Text] [Related]

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