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213 related items for PubMed ID: 33228353

  • 1. L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells.
    Montaser AB, Järvinen J, Löffler S, Huttunen J, Auriola S, Lehtonen M, Jalkanen A, Huttunen KM.
    ACS Chem Neurosci; 2020 Dec 16; 11(24):4301-4315. PubMed ID: 33228353
    [Abstract] [Full Text] [Related]

  • 2. L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery.
    Puris E, Gynther M, Huttunen J, Auriola S, Huttunen KM.
    Eur J Pharm Sci; 2019 Mar 01; 129():99-109. PubMed ID: 30625368
    [Abstract] [Full Text] [Related]

  • 3. L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs.
    Puris E, Gynther M, Huttunen J, Petsalo A, Huttunen KM.
    J Control Release; 2017 Sep 10; 261():93-104. PubMed ID: 28662899
    [Abstract] [Full Text] [Related]

  • 4. L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia.
    Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM.
    Sci Rep; 2019 Sep 06; 9(1):12860. PubMed ID: 31492955
    [Abstract] [Full Text] [Related]

  • 5. Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets.
    Puris E, Gynther M, de Lange ECM, Auriola S, Hammarlund-Udenaes M, Huttunen KM, Loryan I.
    Mol Pharm; 2019 Jul 01; 16(7):3261-3274. PubMed ID: 31180686
    [Abstract] [Full Text] [Related]

  • 6. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.
    Peura L, Malmioja K, Laine K, Leppänen J, Gynther M, Isotalo A, Rautio J.
    Mol Pharm; 2011 Oct 03; 8(5):1857-66. PubMed ID: 21770378
    [Abstract] [Full Text] [Related]

  • 7. Improved l-Type amino acid transporter 1 (LAT1)-mediated delivery of anti-inflammatory drugs into astrocytes and microglia with reduced prostaglandin production.
    Tampio J, Löffler S, Guillon M, Hugele A, Huttunen J, Huttunen KM.
    Int J Pharm; 2021 May 15; 601():120565. PubMed ID: 33812973
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.
    Peura L, Malmioja K, Huttunen K, Leppänen J, Hämäläinen M, Forsberg MM, Gynther M, Rautio J, Laine K.
    Pharm Res; 2013 Oct 15; 30(10):2523-37. PubMed ID: 24137801
    [Abstract] [Full Text] [Related]

  • 9. Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).
    Ylikangas H, Malmioja K, Peura L, Gynther M, Nwachukwu EO, Leppänen J, Laine K, Rautio J, Lahtela-Kakkonen M, Huttunen KM, Poso A.
    ChemMedChem; 2014 Dec 15; 9(12):2699-707. PubMed ID: 25205473
    [Abstract] [Full Text] [Related]

  • 10. Large neutral amino acid transporter enables brain drug delivery via prodrugs.
    Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J.
    J Med Chem; 2008 Feb 28; 51(4):932-6. PubMed ID: 18217702
    [Abstract] [Full Text] [Related]

  • 11. Brain uptake of ketoprofen-lysine prodrug in rats.
    Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J, Rautio J.
    Int J Pharm; 2010 Oct 31; 399(1-2):121-8. PubMed ID: 20727958
    [Abstract] [Full Text] [Related]

  • 12. Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis.
    Tampio J, Markowicz-Piasecka M, Huttunen KM.
    Chem Biol Interact; 2021 Aug 25; 345():109560. PubMed ID: 34153225
    [Abstract] [Full Text] [Related]

  • 13. L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs).
    Huttunen J, Gynther M, Vellonen KS, Huttunen KM.
    Int J Pharm; 2019 Nov 25; 571():118714. PubMed ID: 31610281
    [Abstract] [Full Text] [Related]

  • 14. The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6).
    Tampio J, Montaser AB, Järvinen J, Lehtonen M, Jalkanen AJ, Reinisalo M, Kokkola T, Terasaki T, Laakso M, Rysä J, Kauppinen A, Huttunen KM.
    Eur J Pharm Sci; 2024 Dec 01; 203():106937. PubMed ID: 39419128
    [Abstract] [Full Text] [Related]

  • 15. Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure.
    Gynther M, Peura L, Vernerová M, Leppänen J, Kärkkäinen J, Lehtonen M, Rautio J, Huttunen KM.
    Neurochem Res; 2016 Oct 01; 41(10):2797-2809. PubMed ID: 27412117
    [Abstract] [Full Text] [Related]

  • 16. Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).
    Rautio J, Kärkkäinen J, Huttunen KM, Gynther M.
    Eur J Pharm Sci; 2015 Jan 23; 66():36-40. PubMed ID: 25305508
    [Abstract] [Full Text] [Related]

  • 17. L-Type amino acid transporter 1 as a target for drug delivery.
    Puris E, Gynther M, Auriola S, Huttunen KM.
    Pharm Res; 2020 May 06; 37(5):88. PubMed ID: 32377929
    [Abstract] [Full Text] [Related]

  • 18. L-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors.
    Huttunen KM, Huttunen J, Aufderhaar I, Gynther M, Denny WA, Spicer JA.
    Int J Pharm; 2016 Feb 10; 498(1-2):205-16. PubMed ID: 26705152
    [Abstract] [Full Text] [Related]

  • 19. Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line.
    Takahashi Y, Nishimura T, Higuchi K, Noguchi S, Tega Y, Kurosawa T, Deguchi Y, Tomi M.
    Pharm Res; 2018 Oct 29; 35(12):246. PubMed ID: 30374619
    [Abstract] [Full Text] [Related]

  • 20. The Effects of Prodrug Size and a Carbonyl Linker on l-Type Amino Acid Transporter 1-Targeted Cellular and Brain Uptake.
    Venteicher B, Merklin K, Ngo HX, Chien HC, Hutchinson K, Campbell J, Way H, Griffith J, Alvarado C, Chandra S, Hill E, Schlessinger A, Thomas AA.
    ChemMedChem; 2021 Mar 03; 16(5):869-880. PubMed ID: 33230949
    [Abstract] [Full Text] [Related]

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