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Journal Abstract Search

198 related items for PubMed ID: 33229537

  • 1. The Arg/N-degron pathway targets transcription factors and regulates specific genes.
    Vu TTM, Mitchell DC, Gygi SP, Varshavsky A.
    Proc Natl Acad Sci U S A; 2020 Dec 08; 117(49):31094-31104. PubMed ID: 33229537
    [Abstract] [Full Text] [Related]

  • 2. The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway.
    Vu TTM, Varshavsky A.
    Biochemistry; 2020 Aug 04; 59(30):2796-2812. PubMed ID: 32692156
    [Abstract] [Full Text] [Related]

  • 3. Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling.
    Oh JH, Hyun JY, Chen SJ, Varshavsky A.
    Proc Natl Acad Sci U S A; 2020 May 19; 117(20):10778-10788. PubMed ID: 32366662
    [Abstract] [Full Text] [Related]

  • 4. A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
    Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT.
    Mol Cell Biol; 2005 Aug 19; 25(16):7120-36. PubMed ID: 16055722
    [Abstract] [Full Text] [Related]

  • 5. Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway.
    Xia Z, Webster A, Du F, Piatkov K, Ghislain M, Varshavsky A.
    J Biol Chem; 2008 Aug 29; 283(35):24011-28. PubMed ID: 18566452
    [Abstract] [Full Text] [Related]

  • 6. Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain.
    Du F, Navarro-Garcia F, Xia Z, Tasaki T, Varshavsky A.
    Proc Natl Acad Sci U S A; 2002 Oct 29; 99(22):14110-5. PubMed ID: 12391316
    [Abstract] [Full Text] [Related]

  • 7. Protein quality control degron-containing substrates are differentially targeted in the cytoplasm and nucleus by ubiquitin ligases.
    Hickey CM, Breckel C, Zhang M, Theune WC, Hochstrasser M.
    Genetics; 2021 Mar 03; 217(1):1-19. PubMed ID: 33683364
    [Abstract] [Full Text] [Related]

  • 8. Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo.
    Leboeuf D, Abakumova T, Prikazchikova T, Rhym L, Anderson DG, Zatsepin TS, Piatkov KI.
    Mol Ther; 2020 Apr 08; 28(4):1092-1104. PubMed ID: 32087767
    [Abstract] [Full Text] [Related]

  • 9. The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.
    Hwang CS, Shemorry A, Auerbach D, Varshavsky A.
    Nat Cell Biol; 2010 Dec 08; 12(12):1177-85. PubMed ID: 21076411
    [Abstract] [Full Text] [Related]

  • 10. Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway.
    Turner GC, Du F, Varshavsky A.
    Nature; 2000 Jun 01; 405(6786):579-83. PubMed ID: 10850718
    [Abstract] [Full Text] [Related]

  • 11. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.
    Kume K, Iizumi Y, Shimada M, Ito Y, Kishi T, Yamaguchi Y, Handa H.
    Genes Cells; 2010 Apr 01; 15(4):339-49. PubMed ID: 20298436
    [Abstract] [Full Text] [Related]

  • 12. Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway.
    Oh JH, Hyun JY, Varshavsky A.
    Proc Natl Acad Sci U S A; 2017 May 30; 114(22):E4370-E4379. PubMed ID: 28515311
    [Abstract] [Full Text] [Related]

  • 13. Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
    An JY, Seo JW, Tasaki T, Lee MJ, Varshavsky A, Kwon YT.
    Proc Natl Acad Sci U S A; 2006 Apr 18; 103(16):6212-7. PubMed ID: 16606826
    [Abstract] [Full Text] [Related]

  • 14. N-degron pathways.
    Varshavsky A.
    Proc Natl Acad Sci U S A; 2024 Sep 24; 121(39):e2408697121. PubMed ID: 39264755
    [Abstract] [Full Text] [Related]

  • 15. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
    Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA.
    Nat Commun; 2024 Oct 12; 15(1):8829. PubMed ID: 39396041
    [Abstract] [Full Text] [Related]

  • 16. The substrate recognition domains of the N-end rule pathway.
    Tasaki T, Zakrzewska A, Dudgeon DD, Jiang Y, Lazo JS, Kwon YT.
    J Biol Chem; 2009 Jan 16; 284(3):1884-95. PubMed ID: 19008229
    [Abstract] [Full Text] [Related]

  • 17. N-recognins UBR1 and UBR2 as central ER stress sensors in mammals.
    Le LTHL, Park S, Lee JH, Kim YK, Lee MJ.
    Mol Cells; 2024 Jan 16; 47(1):100001. PubMed ID: 38376480
    [Abstract] [Full Text] [Related]

  • 18. The N-end rule pathway and Ubr1 enforce protein compartmentalization via P2-encoded cellular location signals.
    Tran A.
    J Cell Sci; 2019 May 07; 132(9):. PubMed ID: 30940687
    [Abstract] [Full Text] [Related]

  • 19. Signaling Pathways Regulated by UBR Box-Containing E3 Ligases.
    Kim JG, Shin HC, Seo T, Nawale L, Han G, Kim BY, Kim SJ, Cha-Molstad H.
    Int J Mol Sci; 2021 Aug 03; 22(15):. PubMed ID: 34361089
    [Abstract] [Full Text] [Related]

  • 20. HSV-1-encoded microRNA miR-H1 targets Ubr1 to promote accumulation of neurodegeneration-associated protein.
    Zheng K, Liu Q, Wang S, Ren Z, Kitazato K, Yang D, Wang Y.
    Virus Genes; 2018 Jun 03; 54(3):343-350. PubMed ID: 29541932
    [Abstract] [Full Text] [Related]

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