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Journal Abstract Search

172 related items for PubMed ID: 33279441

  • 1. The search for brain-permeant NKCC1 inhibitors for the treatment of seizures: Pharmacokinetic-pharmacodynamic modelling of NKCC1 inhibition by azosemide, torasemide, and bumetanide in mouse brain.
    Hampel P, Römermann K, Gramer M, Löscher W.
    Epilepsy Behav; 2021 Jan; 114(Pt A):107616. PubMed ID: 33279441
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  • 2. Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice.
    Hampel P, Römermann K, Gailus B, Johne M, Gericke B, Kaczmarek E, Löscher W.
    Neuropharmacology; 2021 Mar 01; 185():108449. PubMed ID: 33450274
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  • 3. The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia.
    Welzel B, Schmidt R, Kirchhoff L, Gramer M, Löscher W.
    Epilepsy Behav; 2023 Feb 01; 139():109057. PubMed ID: 36586153
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  • 10. In vivo effects of bumetanide at brain concentrations incompatible with NKCC1 inhibition on newborn DGC structure and spontaneous EEG seizures following hypoxia-induced neonatal seizures.
    Wang S, Zhang XQ, Song CG, Xiao T, Zhao M, Zhu G, Zhao CS.
    Neuroscience; 2015 Feb 12; 286():203-15. PubMed ID: 25463517
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  • 12. Astrocytic NKCC1 inhibits seizures by buffering Cl- and antagonizing neuronal NKCC1 at GABAergic synapses.
    Nguyen TD, Ishibashi M, Sinha AS, Watanabe M, Kato D, Horiuchi H, Wake H, Fukuda A.
    Epilepsia; 2023 Dec 12; 64(12):3389-3403. PubMed ID: 37779224
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  • 13. Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1.
    Kahle KT, Barnett SM, Sassower KC, Staley KJ.
    J Child Neurol; 2009 May 12; 24(5):572-6. PubMed ID: 19406757
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  • 16. Consequences of inhibition of bumetanide metabolism in rodents on brain penetration and effects of bumetanide in chronic models of epilepsy.
    Töpfer M, Töllner K, Brandt C, Twele F, Bröer S, Löscher W.
    Eur J Neurosci; 2014 Feb 12; 39(4):673-87. PubMed ID: 24251546
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