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153 related items for PubMed ID: 33357981

  • 1. Combined in silico and in vitro studies to identify novel antidiabetic flavonoids targeting glycogen phosphorylase.
    Brás NF, Neves RPP, Lopes FAA, Correia MAS, Palma AS, Sousa SF, Ramos MJ.
    Bioorg Chem; 2021 Mar; 108():104552. PubMed ID: 33357981
    [Abstract] [Full Text] [Related]

  • 2. Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol.
    Tsitsanou KE, Hayes JM, Keramioti M, Mamais M, Oikonomakos NG, Kato A, Leonidas DD, Zographos SE.
    Food Chem Toxicol; 2013 Nov; 61():14-27. PubMed ID: 23279842
    [Abstract] [Full Text] [Related]

  • 3. Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
    Chetter BA, Kyriakis E, Barr D, Karra AG, Katsidou E, Koulas SM, Skamnaki VT, Snape TJ, Psarra AG, Leonidas DD, Hayes JM.
    Bioorg Chem; 2020 Sep; 102():104003. PubMed ID: 32771768
    [Abstract] [Full Text] [Related]

  • 4. An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles.
    Rocha S, Aniceto N, Guedes RC, Albuquerque HMT, Silva VLM, Silva AMS, Corvo ML, Fernandes E, Freitas M.
    Nutrients; 2022 Jan 12; 14(2):. PubMed ID: 35057487
    [Abstract] [Full Text] [Related]

  • 5. Structure-activity relationships of flavonoids as potential inhibitors of glycogen phosphorylase.
    Kato A, Nasu N, Takebayashi K, Adachi I, Minami Y, Sanae F, Asano N, Watson AA, Nash RJ.
    J Agric Food Chem; 2008 Jun 25; 56(12):4469-73. PubMed ID: 18494482
    [Abstract] [Full Text] [Related]

  • 6. Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b.
    Kyriakis E, Stravodimos GA, Kantsadi AL, Chatzileontiadou DS, Skamnaki VT, Leonidas DD.
    FEBS Lett; 2015 Jul 08; 589(15):1787-94. PubMed ID: 25980608
    [Abstract] [Full Text] [Related]

  • 7. Glucose analog inhibitors of glycogen phosphorylases as potential antidiabetic agents: recent developments.
    Somsák L, Nagya V, Hadady Z, Docsa T, Gergely P.
    Curr Pharm Des; 2003 Jul 08; 9(15):1177-89. PubMed ID: 12769745
    [Abstract] [Full Text] [Related]

  • 8. Recent advances in the allosteric inhibition of glycogen phosphorylase.
    Loughlin WA.
    Mini Rev Med Chem; 2010 Oct 08; 10(12):1139-55. PubMed ID: 20716052
    [Abstract] [Full Text] [Related]

  • 9. Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
    Goyard D, Kónya B, Chajistamatiou AS, Chrysina ED, Leroy J, Balzarin S, Tournier M, Tousch D, Petit P, Duret C, Maurel P, Somsák L, Docsa T, Gergely P, Praly JP, Azay-Milhau J, Vidal S.
    Eur J Med Chem; 2016 Jan 27; 108():444-454. PubMed ID: 26708111
    [Abstract] [Full Text] [Related]

  • 10. Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).
    Donnier-Maréchal M, Vidal S.
    Expert Opin Ther Pat; 2016 Jan 27; 26(2):199-212. PubMed ID: 26666989
    [Abstract] [Full Text] [Related]

  • 11. New inhibitors of glycogen phosphorylase as potential antidiabetic agents.
    Somsák L, Czifrák K, Tóth M, Bokor E, Chrysina ED, Alexacou KM, Hayes JM, Tiraidis C, Lazoura E, Leonidas DD, Zographos SE, Oikonomakos NG.
    Curr Med Chem; 2008 Jan 27; 15(28):2933-83. PubMed ID: 19075645
    [Abstract] [Full Text] [Related]

  • 12. Natural flavonoids are potent inhibitors of glycogen phosphorylase.
    Jakobs S, Fridrich D, Hofem S, Pahlke G, Eisenbrand G.
    Mol Nutr Food Res; 2006 Jan 27; 50(1):52-7. PubMed ID: 16317787
    [Abstract] [Full Text] [Related]

  • 13. Computation as a tool for glycogen phosphorylase inhibitor design.
    Hayes JM, Leonidas DD.
    Mini Rev Med Chem; 2010 Oct 27; 10(12):1156-74. PubMed ID: 20716053
    [Abstract] [Full Text] [Related]

  • 14. Advances in glycogen phosphorylase inhibitor design.
    Oikonomakos NG, Somsák L.
    Curr Opin Investig Drugs; 2008 Apr 27; 9(4):379-95. PubMed ID: 18393105
    [Abstract] [Full Text] [Related]

  • 15. 3'-axial CH2 OH substitution on glucopyranose does not increase glycogen phosphorylase inhibitory potency. QM/MM-PBSA calculations suggest why.
    Manta S, Xipnitou A, Kiritsis C, Kantsadi AL, Hayes JM, Skamnaki VT, Lamprakis C, Kontou M, Zoumpoulakis P, Zographos SE, Leonidas DD, Komiotis D.
    Chem Biol Drug Des; 2012 May 27; 79(5):663-73. PubMed ID: 22296957
    [Abstract] [Full Text] [Related]

  • 16. Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors.
    Miao GX, Wang YD, Yan ZW, Zhang LY.
    Bioorg Med Chem Lett; 2020 Jul 15; 30(14):127117. PubMed ID: 32527535
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and biological evaluation of asiatic acid derivatives as inhibitors of glycogen phosphorylases.
    Zhang L, Chen J, Gong Y, Liu J, Zhang L, Hua W, Sun H.
    Chem Biodivers; 2009 Jun 15; 6(6):864-74. PubMed ID: 19551727
    [Abstract] [Full Text] [Related]

  • 18. Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes.
    Leonidas DD, Hayes JM, Kato A, Skamnaki VT, Chatzileontiadou DS, Kantsadi AL, Kyriakis E, Chetter BA, Stravodimos GA.
    Curr Med Chem; 2017 Jun 15; 24(4):384-403. PubMed ID: 27855623
    [Abstract] [Full Text] [Related]

  • 19. Glycogen phosphorylase as a molecular target for type 2 diabetes therapy.
    Oikonomakos NG.
    Curr Protein Pept Sci; 2002 Dec 15; 3(6):561-86. PubMed ID: 12470212
    [Abstract] [Full Text] [Related]

  • 20. Discovery and evaluation of novel benzazepinone derivatives as glycogen phosphorylase inhibitors with potent activity.
    Wang Y, Yan Z, Guo Y, Zhang L.
    Future Med Chem; 2021 May 15; 13(10):897-909. PubMed ID: 33906369
    [Abstract] [Full Text] [Related]

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