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Journal Abstract Search

137 related items for PubMed ID: 3339613

  • 1. Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines.
    Grunewald GL, Sall DJ, Monn JA.
    J Med Chem; 1988 Feb; 31(2):433-44. PubMed ID: 3339613
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  • 3. Effects of a 3-alkyl-, 4-hydroxy- and/or 8-aromatic-substituent on the phenylethanolamine N-methyltransferase inhibitor potency and alpha2-adrenoceptor affinity of 2,3,4,5-tetrahydro-1H-2-benzazepines.
    Grunewald GL, Dahanukar VH, Criscione KR.
    Bioorg Med Chem; 2001 Aug; 9(8):1957-65. PubMed ID: 11504632
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  • 9. Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha2-adrenoceptor.
    Grunewald GL, Dahanukar VH, Jalluri RK, Criscione KR.
    J Med Chem; 1999 Jan 14; 42(1):118-34. PubMed ID: 9888838
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  • 10. Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase.
    Ye QH, Grunewald GL.
    J Med Chem; 1989 Feb 14; 32(2):478-86. PubMed ID: 2913308
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  • 11. Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination.
    Grunewald GL, Seim MR, Lu J, Makboul M, Criscione KR.
    J Med Chem; 2006 May 18; 49(10):2939-52. PubMed ID: 16686536
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  • 13. Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Grunewald GL, Caldwell TM, Li Q, Criscione KR.
    J Med Chem; 1999 Aug 26; 42(17):3315-23. PubMed ID: 10464018
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  • 14. Conformational and steric aspects of phenylethanolamine and phenylethylamine analogues as substrates or inhibitors of phenylethanolamine N-methyltransferase.
    Grunewald GL, Ye Q, Sall DJ, Criscione KR, Wise B.
    Mol Pharmacol; 1989 Jan 26; 35(1):93-7. PubMed ID: 2913486
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  • 15. 1,3-Dimethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as probes for the binding orientation of tetrahydroisoquinoline at the active site of phenylethanolamine N-methyltransferase.
    Grunewald GL, Caldwell TM, Li Q, Criscione KR.
    Bioorg Med Chem; 1999 May 26; 7(5):869-80. PubMed ID: 10400340
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  • 16. Tetrahydrothiadiazoloisoquinolines: synthesis and inhibition of phenylethanolamine-N-methyltransferase.
    Girard GR, Bondinell WE, Hillegass LM, Holden KG, Pendleton RG, Uzinskas I.
    J Med Chem; 1989 Jul 26; 32(7):1566-71. PubMed ID: 2738892
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  • 17. Importance of the aromatic ring in adrenergic amines. 6. Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of pi-electronic and steric interactions.
    Davis DP, Borchardt RT, Grunewald GL.
    J Med Chem; 1981 Jan 26; 24(1):12-6. PubMed ID: 7205869
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  • 20. Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
    Grunewald GL, Seim MR, Regier RC, Martin JL, Gee CL, Drinkwater N, Criscione KR.
    J Med Chem; 2006 Sep 07; 49(18):5424-33. PubMed ID: 16942016
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