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201 related items for PubMed ID: 3339615

  • 1. Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin.
    Hynes JB, Patil SA, Tomazic A, Kumar A, Pathak A, Tan XH, Li XQ, Ratnam M, Delcamp TJ, Freisheim JH.
    J Med Chem; 1988 Feb; 31(2):449-54. PubMed ID: 3339615
    [Abstract] [Full Text] [Related]

  • 2. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A, Galivan J, Beardsley GP, Bader H, O'Connor BM, Russello O, Moroson BA, DeYarman MT, Kerwar SS, Freisheim JH.
    Cancer Res; 1992 Apr 15; 52(8):2148-55. PubMed ID: 1313737
    [Abstract] [Full Text] [Related]

  • 3. Studies on the antitumor effects of analogues of 5,8-dideazaisofolic acid and 5,8-dideazaisoaminopterin.
    Hagan RL, Hynes JB, Pimsler M, Kisliuk RL.
    Biochem Pharmacol; 1995 Sep 07; 50(6):803-9. PubMed ID: 7575641
    [Abstract] [Full Text] [Related]

  • 4. Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1986 Jun 07; 29(6):1080-7. PubMed ID: 2423690
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
    Piper JR, Malik ND, Rhee MS, Galivan J, Sirotnak FM.
    J Med Chem; 1992 Jan 24; 35(2):332-7. PubMed ID: 1732551
    [Abstract] [Full Text] [Related]

  • 6. Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.
    Hynes JB, Patil SA, Hagan RL, Cole A, Kohler W, Freisheim JH.
    J Med Chem; 1989 Apr 24; 32(4):852-6. PubMed ID: 2704031
    [Abstract] [Full Text] [Related]

  • 7. Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo.
    Jackman AL, Taylor GA, O'Connor BM, Bishop JA, Moran RG, Calvert AH.
    Cancer Res; 1990 Sep 01; 50(17):5212-8. PubMed ID: 2386929
    [Abstract] [Full Text] [Related]

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  • 10. The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Jackman AL, Newell DR, Gibson W, Jodrell DI, Taylor GA, Bishop JA, Hughes LR, Calvert AH.
    Biochem Pharmacol; 1991 Oct 24; 42(10):1885-95. PubMed ID: 1741766
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Thorndike J, Sirotnak FM.
    J Med Chem; 1988 Nov 24; 31(11):2164-9. PubMed ID: 3184124
    [Abstract] [Full Text] [Related]

  • 12. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
    Westerhof GR, Schornagel JH, Kathmann I, Jackman AL, Rosowsky A, Forsch RA, Hynes JB, Boyle FT, Peters GJ, Pinedo HM.
    Mol Pharmacol; 1995 Sep 24; 48(3):459-71. PubMed ID: 7565626
    [Abstract] [Full Text] [Related]

  • 13. Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines.
    McNamara DJ, Berman EM, Fry DW, Werbel LM.
    J Med Chem; 1990 Jul 24; 33(7):2045-51. PubMed ID: 2362285
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
    Rosowsky A, Forsch RA, Bader H, Freisheim JH.
    J Med Chem; 1991 Apr 24; 34(4):1447-54. PubMed ID: 2016722
    [Abstract] [Full Text] [Related]

  • 15. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
    Jackman AL, Alison DL, Calvert AH, Harrap KR.
    Cancer Res; 1986 Jun 24; 46(6):2810-5. PubMed ID: 2938731
    [Abstract] [Full Text] [Related]

  • 16. Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.
    Nair MG, Dhawan R, Ghazala M, Kalman TI, Ferone R, Gaumont Y, Kisliuk RL.
    J Med Chem; 1987 Jul 24; 30(7):1256-61. PubMed ID: 3599032
    [Abstract] [Full Text] [Related]

  • 17. Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.
    Rosowsky A, Bader H, Forsch RA, Moran RG, Freisheim JH.
    J Med Chem; 1988 Apr 24; 31(4):763-8. PubMed ID: 3351853
    [Abstract] [Full Text] [Related]

  • 18. Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.
    Taylor EC, Harrington PJ, Fletcher SR, Beardsley GP, Moran RG.
    J Med Chem; 1985 Jul 24; 28(7):914-21. PubMed ID: 4009615
    [Abstract] [Full Text] [Related]

  • 19. Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.
    Jackman AL, Marsham PR, Thornton TJ, Bishop JA, O'Connor BM, Hughes LR, Calvert AH, Jones TR.
    J Med Chem; 1990 Nov 24; 33(11):3067-71. PubMed ID: 2231607
    [Abstract] [Full Text] [Related]

  • 20. Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain.
    Rosowsky A, Moran RC, Forsch RA, Radike-Smith M, Colman PD, Wick MM, Freisheim JH.
    Biochem Pharmacol; 1986 Oct 01; 35(19):3327-33. PubMed ID: 3768024
    [Abstract] [Full Text] [Related]

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