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123 related items for PubMed ID: 33540026

  • 1. Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats.
    Jalkanen AJ, Ihalainen J, Lehtonen M, Forsberg MM, Rautio J, Huttunen KM, Gynther M.
    Int J Pharm; 2021 Mar 01; 596():120300. PubMed ID: 33540026
    [Abstract] [Full Text] [Related]

  • 2. Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets.
    Puris E, Gynther M, de Lange ECM, Auriola S, Hammarlund-Udenaes M, Huttunen KM, Loryan I.
    Mol Pharm; 2019 Jul 01; 16(7):3261-3274. PubMed ID: 31180686
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  • 4. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.
    Peura L, Malmioja K, Laine K, Leppänen J, Gynther M, Isotalo A, Rautio J.
    Mol Pharm; 2011 Oct 03; 8(5):1857-66. PubMed ID: 21770378
    [Abstract] [Full Text] [Related]

  • 5. Brain uptake of ketoprofen-lysine prodrug in rats.
    Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J, Rautio J.
    Int J Pharm; 2010 Oct 31; 399(1-2):121-8. PubMed ID: 20727958
    [Abstract] [Full Text] [Related]

  • 6. L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery.
    Puris E, Gynther M, Huttunen J, Auriola S, Huttunen KM.
    Eur J Pharm Sci; 2019 Mar 01; 129():99-109. PubMed ID: 30625368
    [Abstract] [Full Text] [Related]

  • 7. L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells.
    Montaser AB, Järvinen J, Löffler S, Huttunen J, Auriola S, Lehtonen M, Jalkanen A, Huttunen KM.
    ACS Chem Neurosci; 2020 Dec 16; 11(24):4301-4315. PubMed ID: 33228353
    [Abstract] [Full Text] [Related]

  • 8. L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia.
    Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM.
    Sci Rep; 2019 Sep 06; 9(1):12860. PubMed ID: 31492955
    [Abstract] [Full Text] [Related]

  • 9. Large neutral amino acid transporter enables brain drug delivery via prodrugs.
    Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J.
    J Med Chem; 2008 Feb 28; 51(4):932-6. PubMed ID: 18217702
    [Abstract] [Full Text] [Related]

  • 10. L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels.
    Montaser A, Lehtonen M, Gynther M, Huttunen KM.
    Pharmaceutics; 2020 Apr 11; 12(4):. PubMed ID: 32290494
    [Abstract] [Full Text] [Related]

  • 11. Analysis of L-leucine amino acid transporter species activity and gene expression by human blood brain barrier hCMEC/D3 model reveal potential LAT1, LAT4, B0AT2 and y+LAT1 functional cooperation.
    Taslimifar M, Faltys M, Kurtcuoglu V, Verrey F, Makrides V.
    J Cereb Blood Flow Metab; 2022 Jan 11; 42(1):90-103. PubMed ID: 34427144
    [Abstract] [Full Text] [Related]

  • 12. Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line.
    Takahashi Y, Nishimura T, Higuchi K, Noguchi S, Tega Y, Kurosawa T, Deguchi Y, Tomi M.
    Pharm Res; 2018 Oct 29; 35(12):246. PubMed ID: 30374619
    [Abstract] [Full Text] [Related]

  • 13. Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).
    Rautio J, Kärkkäinen J, Huttunen KM, Gynther M.
    Eur J Pharm Sci; 2015 Jan 23; 66():36-40. PubMed ID: 25305508
    [Abstract] [Full Text] [Related]

  • 14. L-Type amino acid transporter 1 as a target for drug delivery.
    Puris E, Gynther M, Auriola S, Huttunen KM.
    Pharm Res; 2020 May 06; 37(5):88. PubMed ID: 32377929
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.
    Peura L, Malmioja K, Huttunen K, Leppänen J, Hämäläinen M, Forsberg MM, Gynther M, Rautio J, Laine K.
    Pharm Res; 2013 Oct 06; 30(10):2523-37. PubMed ID: 24137801
    [Abstract] [Full Text] [Related]

  • 16. L-type amino acid transporter 1 (LAT1)-utilizing efflux transporter inhibitors can improve the brain uptake and apoptosis-inducing effects of vinblastine in cancer cells.
    Montaser A, Markowicz-Piasecka M, Sikora J, Jalkanen A, Huttunen KM.
    Int J Pharm; 2020 Aug 30; 586():119585. PubMed ID: 32599132
    [Abstract] [Full Text] [Related]

  • 17. Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).
    Ylikangas H, Malmioja K, Peura L, Gynther M, Nwachukwu EO, Leppänen J, Laine K, Rautio J, Lahtela-Kakkonen M, Huttunen KM, Poso A.
    ChemMedChem; 2014 Dec 30; 9(12):2699-707. PubMed ID: 25205473
    [Abstract] [Full Text] [Related]

  • 18. Development of a cell-based screening method for compounds that inhibit or are transported by large neutral amino acid transporter 1, a key transporter at the blood-brain barrier.
    Chen J, Liang L, Liu Y, Zhang L.
    Anal Biochem; 2015 Oct 01; 486():81-5. PubMed ID: 26151684
    [Abstract] [Full Text] [Related]

  • 19. Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis.
    Tampio J, Markowicz-Piasecka M, Huttunen KM.
    Chem Biol Interact; 2021 Aug 25; 345():109560. PubMed ID: 34153225
    [Abstract] [Full Text] [Related]

  • 20. L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production.
    Tampio J, Markowicz-Piasecka M, Montaser A, Rysä J, Kauppinen A, Huttunen KM.
    Mol Pharm; 2022 Nov 07; 19(11):3806-3819. PubMed ID: 36027044
    [Abstract] [Full Text] [Related]

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