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144 related items for PubMed ID: 33647258

  • 1. MIL-1, a novel antitumor agent derived from natural product millepachine, acts as tubulin polymerization inhibitor for the treatment of hepatocellular carcinoma.
    Yan J, Zhuang Q, Li Z, Xiong Y, He M, Kang C, Zhang Q, Han L, Liang E, Liu H, Ke P, Huang X.
    Eur J Pharmacol; 2021 May 05; 898():173975. PubMed ID: 33647258
    [Abstract] [Full Text] [Related]

  • 2. Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo.
    Wu W, Ye H, Wan L, Han X, Wang G, Hu J, Tang M, Duan X, Fan Y, He S, Huang L, Pei H, Wang X, Li X, Xie C, Zhang R, Yuan Z, Mao Y, Wei Y, Chen L.
    Carcinogenesis; 2013 Jul 05; 34(7):1636-43. PubMed ID: 23471882
    [Abstract] [Full Text] [Related]

  • 3. Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma.
    Xiang Q, Zhen Z, Deng DY, Wang J, Chen Y, Li J, Zhang Y, Wang F, Chen N, Chen H, Chen Y.
    J Exp Clin Cancer Res; 2015 Oct 12; 34():118. PubMed ID: 26458953
    [Abstract] [Full Text] [Related]

  • 4. Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells.
    Liao YJ, Bai HY, Li ZH, Zou J, Chen JW, Zheng F, Zhang JX, Mai SJ, Zeng MS, Sun HD, Pu JX, Xie D.
    Cell Death Dis; 2014 Mar 20; 5(3):e1137. PubMed ID: 24651440
    [Abstract] [Full Text] [Related]

  • 5. The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin.
    Yang J, Yan W, Yu Y, Wang Y, Yang T, Xue L, Yuan X, Long C, Liu Z, Chen X, Hu M, Zheng L, Qiu Q, Pei H, Li D, Wang F, Bai P, Wen J, Ye H, Chen L.
    J Biol Chem; 2018 Jun 15; 293(24):9461-9472. PubMed ID: 29691282
    [Abstract] [Full Text] [Related]

  • 6. Novel Indole-Containing Hybrids Derived from Millepachine: Synthesis, Biological Evaluation and Antitumor Mechanism Study.
    Liang B, Zou Q, Yu L, Wang Y, Yan J, Huang B.
    Molecules; 2023 Feb 03; 28(3):. PubMed ID: 36771147
    [Abstract] [Full Text] [Related]

  • 7. Combretastatin A-1 phosphate, a microtubule inhibitor, acts on both hepatocellular carcinoma cells and tumor-associated macrophages by inhibiting the Wnt/β-catenin pathway.
    Mao J, Wang D, Wang Z, Tian W, Li X, Duan J, Wang Y, Yang H, You L, Cheng Y, Bian J, Chen Z, Yang Y.
    Cancer Lett; 2016 Sep 28; 380(1):134-43. PubMed ID: 27349166
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors.
    Wang G, Peng F, Cao D, Yang Z, Han X, Liu J, Wu W, He L, Ma L, Chen J, Sang Y, Xiang M, Peng A, Wei Y, Chen L.
    Bioorg Med Chem; 2013 Nov 01; 21(21):6844-54. PubMed ID: 23993668
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors.
    Yang Z, Wu W, Wang J, Liu L, Li L, Yang J, Wang G, Cao D, Zhang R, Tang M, Wen J, Zhu J, Xiang W, Wang F, Ma L, Xiang M, You J, Chen L.
    J Med Chem; 2014 Oct 09; 57(19):7977-89. PubMed ID: 25208345
    [Abstract] [Full Text] [Related]

  • 10. A review on Millepachine and its derivatives as potential multitarget anticancer agents.
    Rampogu S, Badvel P, Hoon Jo B, Kim Y, Kim SW, Lee KW.
    Biochem Biophys Res Commun; 2023 Nov 12; 681():249-270. PubMed ID: 37793311
    [Abstract] [Full Text] [Related]

  • 11. Pyrrolotetrazinones deazaanalogues of temozolomide induce apoptosis in Jurkat cell line: involvement of tubulin polymerization inhibition.
    Viola G, Cecconet L, Leszl A, Basso G, Brun P, Salvador A, Dall'Acqua F, Diana P, Barraja P, Cirrincione G.
    Cancer Chemother Pharmacol; 2009 Nov 12; 64(6):1235-51. PubMed ID: 19363609
    [Abstract] [Full Text] [Related]

  • 12.
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  • 13. Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors.
    An B, Zhang S, Yan J, Huang L, Li X.
    Org Biomol Chem; 2017 Jan 25; 15(4):852-862. PubMed ID: 28009925
    [Abstract] [Full Text] [Related]

  • 14. DMAMCL exerts antitumor effects on hepatocellular carcinoma both in vitro and in vivo.
    Yao S, Ye J, Yin M, Yu R.
    Cancer Lett; 2020 Jul 28; 483():87-97. PubMed ID: 32268165
    [Abstract] [Full Text] [Related]

  • 15. XN05, a novel synthesized microtubule inhibitor, exhibits potent activity against human carcinoma cells in vitro.
    Wu R, Ding W, Liu T, Zhu H, Hu Y, Yang B, He Q.
    Cancer Lett; 2009 Nov 18; 285(1):13-22. PubMed ID: 19647933
    [Abstract] [Full Text] [Related]

  • 16. Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence.
    Zhu C, Zuo Y, Wang R, Liang B, Yue X, Wen G, Shang N, Huang L, Chen Y, Du J, Bu X.
    J Med Chem; 2014 Aug 14; 57(15):6364-82. PubMed ID: 25061803
    [Abstract] [Full Text] [Related]

  • 17. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.
    Wang SW, Pan SL, Huang YC, Guh JH, Chiang PC, Huang DY, Kuo SC, Lee KH, Teng CM.
    Mol Cancer Ther; 2008 Feb 14; 7(2):350-60. PubMed ID: 18281518
    [Abstract] [Full Text] [Related]

  • 18. A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells.
    Ho CT, Chang YJ, Yang LX, Wei PL, Liu TZ, Liu JJ.
    PLoS One; 2015 Feb 14; 10(9):e0136340. PubMed ID: 26355599
    [Abstract] [Full Text] [Related]

  • 19. The effect and mechanism of millepachine-disrupted spindle assembly in tumor cells.
    Wu W, Liu F, Su A, Gong Y, Zhao W, Liu Y, Ye H, Zhu J.
    Anticancer Drugs; 2018 Jun 14; 29(5):449-456. PubMed ID: 29649038
    [Abstract] [Full Text] [Related]

  • 20. C118P, a novel microtubule inhibitor with anti-angiogenic and vascular disrupting activities, exerts anti-tumor effects against hepatocellular carcinoma.
    Yang M, Su Y, Wang Z, Du D, Wei S, Liao Z, Zhang Q, Zhao L, Zhang X, Han L, Jiang J, Zhan M, Sun L, Yuan S, Zhou Z.
    Biochem Pharmacol; 2021 Aug 14; 190():114641. PubMed ID: 34077738
    [Abstract] [Full Text] [Related]

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