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Journal Abstract Search

219 related items for PubMed ID: 33676043

  • 1. 3,7-bis-benzylidene hydrazide ciprofloxacin derivatives as promising antiproliferative dual TOP I & TOP II isomerases inhibitors.
    Samir M, Ramadan M, Abdelrahman MH, Abdelbaset MS, Abourehab MAS, Abdel-Aziz M, Abuo-Rahma GEA.
    Bioorg Chem; 2021 May; 110():104698. PubMed ID: 33676043
    [Abstract] [Full Text] [Related]

  • 2. Novel urea linked ciprofloxacin-chalcone hybrids having antiproliferative topoisomerases I/II inhibitory activities and caspases-mediated apoptosis.
    Mohammed HHH, Abbas SH, Hayallah AM, Abuo-Rahma GEA, Mostafa YA.
    Bioorg Chem; 2021 Jan; 106():104422. PubMed ID: 33248713
    [Abstract] [Full Text] [Related]

  • 3. Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity.
    Kassab AE, Gedawy EM.
    Eur J Med Chem; 2018 Apr 25; 150():403-418. PubMed ID: 29547830
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors.
    My Van HT, Woo H, Jeong HM, Khadka DB, Yang SH, Zhao C, Jin Y, Lee ES, Youl Lee K, Kwon Y, Cho WJ.
    Eur J Med Chem; 2014 Jul 23; 82():181-94. PubMed ID: 24904965
    [Abstract] [Full Text] [Related]

  • 5. Design, synthesis and mechanistic study of N-4-Piperazinyl Butyryl Thiazolidinedione derivatives of ciprofloxacin with Anticancer Activity via Topoisomerase I/II inhibition.
    Aziz HA, El-Saghier AM, Badr M, Elsadek BEM, Abuo-Rahma GEA, Shoman ME.
    Sci Rep; 2024 Oct 15; 14(1):24101. PubMed ID: 39406816
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.
    Zhuo ST, Li CY, Hu MH, Chen SB, Yao PF, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS.
    Org Biomol Chem; 2013 Jun 28; 11(24):3989-4005. PubMed ID: 23657605
    [Abstract] [Full Text] [Related]

  • 7. Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity.
    Abdel-Aziz M, Park SE, Abuo-Rahma Gel-D, Sayed MA, Kwon Y.
    Eur J Med Chem; 2013 Nov 28; 69():427-38. PubMed ID: 24090914
    [Abstract] [Full Text] [Related]

  • 8. Pharmacophore-based, rationale design, and efficient synthesis of novel tetrahydrobenzo[b]thiophene candidates as potential dual Topo I/II inhibitors and DNA intercalators.
    Nofal HR, Al-Karmalawy AA, Elmaaty AA, Ismail MF, Ali AK, Abbass EM.
    Arch Pharm (Weinheim); 2024 Sep 28; 357(9):e2400217. PubMed ID: 38864845
    [Abstract] [Full Text] [Related]

  • 9. Pyrroloquinolinone-based dual topoisomerase I/II inhibitor.
    Dalla Via L, Marzaro G, Ferrarese A, Gia O, Chilin A.
    Eur J Med Chem; 2014 Apr 22; 77():103-9. PubMed ID: 24631729
    [Abstract] [Full Text] [Related]

  • 10. Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor.
    Park S, Thapa Magar TB, Kadayat TM, Lee HJ, Bist G, Shrestha A, Lee ES, Kwon Y.
    Eur J Med Chem; 2017 Feb 15; 127():318-333. PubMed ID: 28068603
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis, molecular docking and anti-proliferative evaluations of [1,2,4]triazolo[4,3-a]quinoxaline derivatives as DNA intercalators and Topoisomerase II inhibitors.
    El-Adl K, El-Helby AA, Sakr H, Elwan A.
    Bioorg Chem; 2020 Dec 15; 105():104399. PubMed ID: 33113414
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors.
    Yao BL, Mai YW, Chen SB, Xie HT, Yao PF, Ou TM, Tan JH, Wang HG, Li D, Huang SL, Gu LQ, Huang ZS.
    Eur J Med Chem; 2015 Mar 06; 92():540-53. PubMed ID: 25599951
    [Abstract] [Full Text] [Related]

  • 13. Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors.
    Eissa IH, Metwaly AM, Belal A, Mehany ABM, Ayyad RR, El-Adl K, Mahdy HA, Taghour MS, El-Gamal KMA, El-Sawah ME, Elmetwally SA, Elhendawy MA, Radwan MM, ElSohly MA.
    Arch Pharm (Weinheim); 2019 Nov 06; 352(11):e1900123. PubMed ID: 31463953
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents.
    Thapa P, Kadayat TM, Park S, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES.
    Bioorg Chem; 2016 Jun 06; 66():145-59. PubMed ID: 27174797
    [Abstract] [Full Text] [Related]

  • 15. Novel nalidixic acid derivatives targeting topoisomerase II enzyme; Design, synthesis, anticancer activity and effect on cell cycle profile.
    Khalil OM, Gedawy EM, El-Malah AA, Adly ME.
    Bioorg Chem; 2019 Mar 06; 83():262-276. PubMed ID: 30391699
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors.
    Ibrahim MK, Taghour MS, Metwaly AM, Belal A, Mehany ABM, Elhendawy MA, Radwan MM, Yassin AM, El-Deeb NM, Hafez EE, ElSohly MA, Eissa IH.
    Eur J Med Chem; 2018 Jul 15; 155():117-134. PubMed ID: 29885574
    [Abstract] [Full Text] [Related]

  • 17. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines.
    Kadayat TM, Song C, Shin S, Magar TB, Bist G, Shrestha A, Thapa P, Na Y, Kwon Y, Lee ES.
    Bioorg Med Chem; 2015 Jul 01; 23(13):3499-512. PubMed ID: 26022080
    [Abstract] [Full Text] [Related]

  • 18. A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study.
    Karki R, Jun KY, Kadayat TM, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES.
    Eur J Med Chem; 2016 May 04; 113():228-45. PubMed ID: 26945111
    [Abstract] [Full Text] [Related]

  • 19. Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships.
    Kunwar S, Hwang SY, Katila P, Man Kadayat T, Jung AR, Kwon Y, Lee ES.
    Bioorg Med Chem Lett; 2022 Mar 15; 60():128606. PubMed ID: 35123005
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor.
    Ahmad P, Woo H, Jun KY, Kadi AA, Abdel-Aziz HA, Kwon Y, Rahman AF.
    Bioorg Med Chem; 2016 Apr 15; 24(8):1898-908. PubMed ID: 26988802
    [Abstract] [Full Text] [Related]

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