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Journal Abstract Search

176 related items for PubMed ID: 33788562

  • 1. Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities.
    Ren Y, Wang Y, Li G, Zhang Z, Ma L, Cheng B, Chen J.
    J Med Chem; 2021 Apr 22; 64(8):4498-4515. PubMed ID: 33788562
    [Abstract] [Full Text] [Related]

  • 2. Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.
    Li Y, Liu Y, Zhu Z, Yan W, Zhang C, Yang Z, Bai P, Tang M, Shi M, He W, Fu S, Liu J, Han K, Li J, Xie L, Ye H, Yang J, Chen L.
    J Med Chem; 2022 Feb 10; 65(3):2675-2693. PubMed ID: 35084853
    [Abstract] [Full Text] [Related]

  • 3. Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities.
    Zhu H, Li W, Shuai W, Liu Y, Yang L, Tan Y, Zheng T, Yao H, Xu J, Zhu Z, Yang DH, Chen ZS, Xu S.
    Eur J Med Chem; 2021 Apr 15; 216():113316. PubMed ID: 33676300
    [Abstract] [Full Text] [Related]

  • 4. X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma.
    Ren Y, Wang Y, Liu J, Liu T, Yuan L, Wu C, Yang Z, Chen J.
    J Med Chem; 2023 May 25; 66(10):6697-6714. PubMed ID: 37145846
    [Abstract] [Full Text] [Related]

  • 5. Discovery of novel thiophene[3,2-d]pyrimidine-based tubulin inhibitors with enhanced antitumor efficacy for combined use with anti-pd-l1 immunotherapy in melanoma.
    Xu C, Wu C, Li L, Zhao H, Liu J, Peng X, Wang Y, Chen J.
    Eur J Med Chem; 2024 Nov 05; 277():116791. PubMed ID: 39197251
    [Abstract] [Full Text] [Related]

  • 6. Synthesis, molecular docking and biological evaluation of 1-phenylsulphonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as novel potential tubulin assembling inhibitors.
    Wang YT, Cai XC, Shi TQ, Zhang YL, Wang ZC, Liu CH, Zhu HL.
    Chem Biol Drug Des; 2017 Jul 05; 90(1):112-118. PubMed ID: 28032450
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.
    Lai Q, Wang Y, Wang R, Lai W, Tang L, Tao Y, Liu Y, Zhang R, Huang L, Xiang H, Zeng S, Gou L, Chen H, Yao Y, Yang J.
    Eur J Med Chem; 2018 Aug 05; 156():162-179. PubMed ID: 30006162
    [Abstract] [Full Text] [Related]

  • 8. Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
    Chen H, Deng S, Albadari N, Yun MK, Zhang S, Li Y, Ma D, Parke DN, Yang L, Seagroves TN, White SW, Miller DD, Li W.
    J Med Chem; 2021 Aug 26; 64(16):12049-12074. PubMed ID: 34378386
    [Abstract] [Full Text] [Related]

  • 9. Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors.
    Cao D, Liu Y, Yan W, Wang C, Bai P, Wang T, Tang M, Wang X, Yang Z, Ma B, Ma L, Lei L, Wang F, Xu B, Zhou Y, Yang T, Chen L.
    J Med Chem; 2016 Jun 23; 59(12):5721-39. PubMed ID: 27213819
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.
    Li G, Wang Y, Li L, Ren Y, Deng X, Liu J, Wang W, Luo M, Liu S, Chen J.
    Eur J Med Chem; 2020 Sep 15; 202():112519. PubMed ID: 32650183
    [Abstract] [Full Text] [Related]

  • 11. Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues.
    Pecnard S, Hamze A, Bignon J, Prost B, Deroussent A, Gallego-Yerga L, Peláez R, Paik JY, Diederich M, Alami M, Provot O.
    Eur J Med Chem; 2021 Nov 05; 223():113656. PubMed ID: 34171660
    [Abstract] [Full Text] [Related]

  • 12. Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.
    Arnst KE, Wang Y, Lei ZN, Hwang DJ, Kumar G, Ma D, Parke DN, Chen Q, Yang J, White SW, Seagroves TN, Chen ZS, Miller DD, Li W.
    Mol Pharmacol; 2019 Jul 05; 96(1):73-89. PubMed ID: 31043459
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis and biological evaluation of benz-fused five-membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities.
    Komuraiah B, Ren Y, Xue M, Cheng B, Liu J, Liu Y, Chen J.
    Chem Biol Drug Des; 2021 May 05; 97(5):1109-1116. PubMed ID: 33638903
    [Abstract] [Full Text] [Related]

  • 14. The cytotoxic natural compound erianin binds to colchicine site of β-tubulin and overcomes taxane resistance.
    Yan W, Zhou Y, Yuan X, Bai P, Tang M, Chen L, Wei H, Yang J.
    Bioorg Chem; 2024 Sep 05; 150():107569. PubMed ID: 38905886
    [Abstract] [Full Text] [Related]

  • 15. The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo.
    Cui YJ, Ma CC, Zhang CM, Tang LQ, Liu ZP.
    Eur J Med Chem; 2020 Feb 01; 187():111968. PubMed ID: 31865012
    [Abstract] [Full Text] [Related]

  • 16. Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors.
    Wang YT, Shi TQ, Zhu HL, Liu CH.
    Bioorg Med Chem; 2019 Feb 01; 27(3):502-515. PubMed ID: 30606674
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis and biological evaluation of (E)-3-(3,4-dihydroxyphenyl)acrylylpiperazine derivatives as a new class of tubulin polymerization inhibitors.
    Yin Y, Qiao F, Jiang LY, Wang SF, Sha S, Wu X, Lv PC, Zhu HL.
    Bioorg Med Chem; 2014 Aug 01; 22(15):4285-92. PubMed ID: 24916028
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and biological evaluation of novel benzo[c]acridine-diones as potential anticancer agents and tubulin polymerization inhibitors.
    Behbahani FS, Tabeshpour J, Mirzaei S, Golmakaniyoon S, Tayarani-Najaran Z, Ghasemi A, Ghodsi R.
    Arch Pharm (Weinheim); 2019 Jun 01; 352(6):e1800307. PubMed ID: 31012156
    [Abstract] [Full Text] [Related]

  • 19. Synthesis, biological evaluation, and molecular docking studies of novel 1-benzene acyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as potential tubulin polymerization inhibitors.
    Wang YT, Qin YJ, Yang N, Zhang YL, Liu CH, Zhu HL.
    Eur J Med Chem; 2015 Jun 24; 99():125-37. PubMed ID: 26070164
    [Abstract] [Full Text] [Related]

  • 20. A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance.
    Arnst KE, Wang Y, Hwang DJ, Xue Y, Costello T, Hamilton D, Chen Q, Yang J, Park F, Dalton JT, Miller DD, Li W.
    Cancer Res; 2018 Jan 01; 78(1):265-277. PubMed ID: 29180476
    [Abstract] [Full Text] [Related]

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