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206 related items for PubMed ID: 34035124

  • 1. Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
    Preiss LC, Liu R, Hewitt P, Thompson D, Georgi K, Badolo L, Lauschke VM, Petersson C.
    Drug Metab Dispos; 2021 Aug; 49(8):668-678. PubMed ID: 34035124
    [Abstract] [Full Text] [Related]

  • 2. Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
    Chang HY, Chen CJ, Ma WC, Cheng WK, Lin YN, Lee YR, Chen JJ, Lim YP.
    Phytomedicine; 2017 Dec 01; 36():37-49. PubMed ID: 29157826
    [Abstract] [Full Text] [Related]

  • 3. Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization.
    Takano H, Yamaguchi JI, Kato S, Hamada M, Tada M, Endo H.
    Drug Metab Dispos; 2021 Jan 01; 49(1):20-30. PubMed ID: 33087449
    [Abstract] [Full Text] [Related]

  • 4. Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor.
    Hu Q, Yao N, Wu J, Liu M, Liu F, Zhang H, Xiong Y, Xia C.
    Biochem Pharmacol; 2019 Jan 01; 159():32-39. PubMed ID: 30414935
    [Abstract] [Full Text] [Related]

  • 5. Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.
    Lim YP, Cheng CH, Chen WC, Chang SY, Hung DZ, Chen JJ, Wan L, Ma WC, Lin YH, Chen CY, Yokoi T, Nakajima M, Chen CJ.
    Arch Toxicol; 2015 Jan 01; 89(1):57-72. PubMed ID: 25069801
    [Abstract] [Full Text] [Related]

  • 6. Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor.
    Li L, Welch MA, Li Z, Mackowiak B, Heyward S, Swaan PW, Wang H.
    Mol Pharmacol; 2019 Sep 01; 96(3):345-354. PubMed ID: 31436536
    [Abstract] [Full Text] [Related]

  • 7. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.
    Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL.
    J Biochem Mol Toxicol; 2009 Sep 01; 23(1):43-58. PubMed ID: 19202563
    [Abstract] [Full Text] [Related]

  • 8. Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2.
    Rhodes SP, Otten JN, Hingorani GP, Hartley DP, Franklin RB.
    J Pharmacol Toxicol Methods; 2011 Sep 01; 63(3):223-6. PubMed ID: 21111054
    [Abstract] [Full Text] [Related]

  • 9. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
    Casabar RC, Das PC, Dekrey GK, Gardiner CS, Cao Y, Rose RL, Wallace AD.
    Toxicol Appl Pharmacol; 2010 Jun 15; 245(3):335-43. PubMed ID: 20361990
    [Abstract] [Full Text] [Related]

  • 10. Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells.
    Ogasawara A, Kato N, Torimoto N, Aohara F, Ohashi R, Yamada Y, Taniguchi H.
    Drug Metab Lett; 2018 Jun 15; 12(1):14-23. PubMed ID: 29357810
    [Abstract] [Full Text] [Related]

  • 11. Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells.
    Sachar M, Kelly EJ, Unadkat JD.
    AAPS J; 2019 Mar 27; 21(3):45. PubMed ID: 30919109
    [Abstract] [Full Text] [Related]

  • 12. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.
    Drug Metab Dispos; 2007 Jul 27; 35(7):1032-41. PubMed ID: 17392393
    [Abstract] [Full Text] [Related]

  • 13. Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor.
    Kohalmy K, Tamási V, Kóbori L, Sárváry E, Pascussi JM, Porrogi P, Rozman D, Prough RA, Meyer UA, Monostory K.
    Drug Metab Dispos; 2007 Sep 27; 35(9):1495-501. PubMed ID: 17591676
    [Abstract] [Full Text] [Related]

  • 14. Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells.
    McGinnity DF, Zhang G, Kenny JR, Hamilton GA, Otmani S, Stams KR, Haney S, Brassil P, Stresser DM, Riley RJ.
    Drug Metab Dispos; 2009 Jun 27; 37(6):1259-68. PubMed ID: 19307295
    [Abstract] [Full Text] [Related]

  • 15. Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation.
    Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W.
    Pharm Res; 2013 Sep 27; 30(9):2199-208. PubMed ID: 23896737
    [Abstract] [Full Text] [Related]

  • 16. Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes.
    Hendriks DFG, Vorrink SU, Smutny T, Sim SC, Nordling Å, Ullah S, Kumondai M, Jones BC, Johansson I, Andersson TB, Lauschke VM, Ingelman-Sundberg M.
    Clin Pharmacol Ther; 2020 Oct 27; 108(4):844-855. PubMed ID: 32320483
    [Abstract] [Full Text] [Related]

  • 17. Evaluation of a novel PXR-knockout in HepaRG™ cells.
    Williamson B, Lorbeer M, Mitchell MD, Brayman TG, Riley RJ.
    Pharmacol Res Perspect; 2016 Oct 27; 4(5):e00264. PubMed ID: 27713827
    [Abstract] [Full Text] [Related]

  • 18. Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells.
    Savary CC, Jossé R, Bruyère A, Guillet F, Robin MA, Guillouzo A.
    Drug Metab Dispos; 2014 Aug 27; 42(8):1235-40. PubMed ID: 24832206
    [Abstract] [Full Text] [Related]

  • 19. Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor.
    Hoffart E, Ghebreghiorghis L, Nussler AK, Thasler WE, Weiss TS, Schwab M, Burk O.
    Br J Pharmacol; 2012 Mar 27; 165(5):1595-608. PubMed ID: 21913896
    [Abstract] [Full Text] [Related]

  • 20. Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes.
    Li Z, Li L, Heyward S, Men S, Xu M, Sueyoshi T, Wang H.
    Cells; 2021 Dec 01; 10(12):. PubMed ID: 34943889
    [Abstract] [Full Text] [Related]

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