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Journal Abstract Search

126 related items for PubMed ID: 34097389

  • 1. Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents.
    Peng X, Chen J, Li L, Sun Z, Liu J, Ren Y, Huang J, Chen J.
    J Med Chem; 2021 Jun 24; 64(12):8447-8473. PubMed ID: 34097389
    [Abstract] [Full Text] [Related]

  • 2. Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma.
    Peng X, Li L, Chen J, Ren Y, Liu J, Yu Z, Cao H, Chen J.
    J Med Chem; 2022 Feb 10; 65(3):2434-2457. PubMed ID: 35043615
    [Abstract] [Full Text] [Related]

  • 3. CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition.
    Singh A, Chang TY, Kaur N, Hsu KC, Yen Y, Lin TE, Lai MJ, Lee SB, Liou JP.
    Eur J Med Chem; 2021 Apr 05; 215():113169. PubMed ID: 33588178
    [Abstract] [Full Text] [Related]

  • 4. Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity.
    Mourad AAE, Mourad MAE, Jones PG.
    Drug Des Devel Ther; 2020 Apr 05; 14():3111-3130. PubMed ID: 32848361
    [Abstract] [Full Text] [Related]

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  • 6. Design, synthesis and biological evaluation of benz-fused five-membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities.
    Komuraiah B, Ren Y, Xue M, Cheng B, Liu J, Liu Y, Chen J.
    Chem Biol Drug Des; 2021 May 05; 97(5):1109-1116. PubMed ID: 33638903
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  • 8. Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.
    Yang Z, Shen M, Tang M, Zhang W, Cui X, Zhang Z, Pei H, Li Y, Hu M, Bai P, Chen L.
    Eur J Med Chem; 2019 Sep 15; 178():116-130. PubMed ID: 31177073
    [Abstract] [Full Text] [Related]

  • 9. Discovery of novel thiophene[3,2-d]pyrimidine-based tubulin inhibitors with enhanced antitumor efficacy for combined use with anti-pd-l1 immunotherapy in melanoma.
    Xu C, Wu C, Li L, Zhao H, Liu J, Peng X, Wang Y, Chen J.
    Eur J Med Chem; 2024 Nov 05; 277():116791. PubMed ID: 39197251
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors.
    Shuai W, Li X, Li W, Xu F, Lu L, Yao H, Yang L, Zhu H, Xu S, Zhu Z, Xu J.
    Eur J Med Chem; 2020 Jul 01; 197():112308. PubMed ID: 32339853
    [Abstract] [Full Text] [Related]

  • 11. Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
    Chen H, Deng S, Albadari N, Yun MK, Zhang S, Li Y, Ma D, Parke DN, Yang L, Seagroves TN, White SW, Miller DD, Li W.
    J Med Chem; 2021 Aug 26; 64(16):12049-12074. PubMed ID: 34378386
    [Abstract] [Full Text] [Related]

  • 12. Synthesis, biological evaluation, and molecular docking analysis of novel linker-less benzamide based potent and selective HDAC3 inhibitors.
    Routholla G, Pulya S, Patel T, Abdul Amin S, Adhikari N, Biswas S, Jha T, Ghosh B.
    Bioorg Chem; 2021 Sep 26; 114():105050. PubMed ID: 34120025
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
    Zhang X, Kong Y, Zhang J, Su M, Zhou Y, Zang Y, Li J, Chen Y, Fang Y, Zhang X, Lu W.
    Eur J Med Chem; 2015 May 05; 95():127-35. PubMed ID: 25805446
    [Abstract] [Full Text] [Related]

  • 14. Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.
    Li Y, Liu Y, Zhu Z, Yan W, Zhang C, Yang Z, Bai P, Tang M, Shi M, He W, Fu S, Liu J, Han K, Li J, Xie L, Ye H, Yang J, Chen L.
    J Med Chem; 2022 Feb 10; 65(3):2675-2693. PubMed ID: 35084853
    [Abstract] [Full Text] [Related]

  • 15. Discovery of a 2,6-diarylpyridine-based hydroxamic acid derivative as novel histone deacetylase 8 and tubulin dual inhibitor for the treatment of neuroblastoma.
    Tang H, Liang Y, Shen H, Cai S, Yu M, Fan H, Ding K, Wang Y.
    Bioorg Chem; 2022 Nov 10; 128():106112. PubMed ID: 36070628
    [Abstract] [Full Text] [Related]

  • 16. Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study.
    Ma W, Chen P, Huo X, Ma Y, Li Y, Diao P, Yang F, Zheng S, Hu M, You W, Zhao P.
    Eur J Med Chem; 2020 Dec 15; 208():112847. PubMed ID: 33022479
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors.
    Wang G, Peng F, Cao D, Yang Z, Han X, Liu J, Wu W, He L, Ma L, Chen J, Sang Y, Xiang M, Peng A, Wei Y, Chen L.
    Bioorg Med Chem; 2013 Nov 01; 21(21):6844-54. PubMed ID: 23993668
    [Abstract] [Full Text] [Related]

  • 18. A novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo.
    Li YR, Liu FF, Liu WB, Zhang YF, Tian XY, Fu XJ, Xu Y, Song J, Zhang SY.
    Biochem Pharmacol; 2022 Jul 01; 201():115070. PubMed ID: 35526597
    [Abstract] [Full Text] [Related]

  • 19. Discovery of novel CA-4 analogs as dual inhibitors of tubulin polymerization and PD-1/PD-L1 interaction for cancer treatment.
    Yang X, Cheng B, Xiao Y, Xue M, Liu T, Cao H, Chen J.
    Eur J Med Chem; 2021 Mar 05; 213():113058. PubMed ID: 33280898
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site.
    Shao YY, Yin Y, Lian BP, Leng JF, Xia YZ, Kong LY.
    Eur J Med Chem; 2020 Mar 15; 190():112105. PubMed ID: 32035399
    [Abstract] [Full Text] [Related]

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