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Journal Abstract Search

133 related items for PubMed ID: 34153225

  • 21. Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure.
    Gynther M, Peura L, Vernerová M, Leppänen J, Kärkkäinen J, Lehtonen M, Rautio J, Huttunen KM.
    Neurochem Res; 2016 Oct; 41(10):2797-2809. PubMed ID: 27412117
    [Abstract] [Full Text] [Related]

  • 22. The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6).
    Tampio J, Montaser AB, Järvinen J, Lehtonen M, Jalkanen AJ, Reinisalo M, Kokkola T, Terasaki T, Laakso M, Rysä J, Kauppinen A, Huttunen KM.
    Eur J Pharm Sci; 2024 Dec 01; 203():106937. PubMed ID: 39419128
    [Abstract] [Full Text] [Related]

  • 23. Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug.
    Thiele NA, Kärkkäinen J, Sloan KB, Rautio J, Huttunen KM.
    Bioorg Med Chem Lett; 2018 Sep 15; 28(17):2856-2860. PubMed ID: 30055889
    [Abstract] [Full Text] [Related]

  • 24. Brain uptake of ketoprofen-lysine prodrug in rats.
    Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J, Rautio J.
    Int J Pharm; 2010 Oct 31; 399(1-2):121-8. PubMed ID: 20727958
    [Abstract] [Full Text] [Related]

  • 25. Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain.
    Montaser A, Huttunen J, Ibrahim SA, Huttunen KM.
    Oxid Med Cell Longev; 2019 Oct 31; 2019():3528148. PubMed ID: 31814871
    [Abstract] [Full Text] [Related]

  • 26. Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma.
    Srisongkram T, Bahrami K, Järvinen J, Timonen J, Rautio J, Weerapreeyakul N.
    Int J Mol Sci; 2022 Jul 30; 23(15):. PubMed ID: 35955600
    [Abstract] [Full Text] [Related]

  • 27. Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion.
    Ylikangas H, Peura L, Malmioja K, Leppänen J, Laine K, Poso A, Lahtela-Kakkonen M, Rautio J.
    Eur J Pharm Sci; 2013 Feb 14; 48(3):523-31. PubMed ID: 23228412
    [Abstract] [Full Text] [Related]

  • 28. Targeting L-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics.
    Jin SE, Jin HE, Hong SS.
    Expert Opin Ther Targets; 2015 Feb 14; 19(10):1319-37. PubMed ID: 25968633
    [Abstract] [Full Text] [Related]

  • 29. Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain.
    Hugele A, Löffler S, Molina BH, Guillon M, Montaser AB, Auriola S, Huttunen KM.
    Front Pharmacol; 2022 Feb 14; 13():1034964. PubMed ID: 36339537
    [Abstract] [Full Text] [Related]

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  • 31. Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands.
    Huttunen J, Agami M, Tampio J, Montaser AB, Huttunen KM.
    Molecules; 2021 Dec 22; 27(1):. PubMed ID: 35011270
    [Abstract] [Full Text] [Related]

  • 32. Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation.
    Kärkkäinen J, Laitinen T, Markowicz-Piasecka M, Montaser A, Lehtonen M, Rautio J, Gynther M, Poso A, Huttunen KM.
    Bioorg Chem; 2021 Jul 22; 112():104921. PubMed ID: 33933805
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  • 34. Identification of human, rat and mouse hydrolyzing enzymes bioconverting amino acid ester prodrug of ketoprofen.
    Huttunen KM.
    Bioorg Chem; 2018 Dec 22; 81():494-503. PubMed ID: 30243240
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  • 37. LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.
    Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA.
    Bioorg Med Chem Lett; 2016 Oct 15; 26(20):5000-5006. PubMed ID: 27624080
    [Abstract] [Full Text] [Related]

  • 38. l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.
    Hall C, Wolfe H, Wells A, Chien HC, Colas C, Schlessinger A, Giacomini KM, Thomas AA.
    Bioorg Med Chem Lett; 2019 Aug 15; 29(16):2254-2258. PubMed ID: 31248771
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