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Journal Abstract Search

220 related items for PubMed ID: 34157326

  • 1. Astragaloside IV inhibits hepatocellular carcinoma by continually suppressing the development of fibrosis and regulating pSmad3C/3L and Nrf2/HO-1 pathways.
    Zhang C, Li L, Hou S, Shi Z, Xu W, Wang Q, He Y, Gong Y, Fang Z, Yang Y.
    J Ethnopharmacol; 2021 Oct 28; 279():114350. PubMed ID: 34157326
    [Abstract] [Full Text] [Related]

  • 2. Astragaloside IV suppresses migration and invasion of TGF-β1-induced human hepatoma HuH-7 cells by regulating Nrf2/HO-1 and TGF-β1/Smad3 pathways.
    Li L, Wang Q, He Y, Sun L, Yang Y, Pang X.
    Naunyn Schmiedebergs Arch Pharmacol; 2022 Apr 28; 395(4):397-405. PubMed ID: 35092472
    [Abstract] [Full Text] [Related]

  • 3. Nrf2 knockout attenuates the astragaloside IV therapeutic effect on kidney fibrosis from liver cancer by regulating pSmad3C/3L pathways.
    Wang Q, Xu J, Li M, Chen Y, Xu Y, Li L, Gong Y, Yang Y.
    Naunyn Schmiedebergs Arch Pharmacol; 2024 Mar 28; 397(3):1687-1700. PubMed ID: 37712971
    [Abstract] [Full Text] [Related]

  • 4. Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocellular carcinoma progression via miR-145/miR-21 mediated Smad3 phosphorylation.
    Wu C, Chen W, Fang M, Boye A, Tao X, Xu Y, Hou S, Yang Y.
    J Ethnopharmacol; 2019 Mar 01; 231():98-112. PubMed ID: 30412748
    [Abstract] [Full Text] [Related]

  • 5. Amelioratory effects of astragaloside IV on hepatocarcinogenesis via Nrf2-mediated pSmad3C/3L transformation.
    Fang Gong Y, Hou S, Xu JC, Chen Y, Zhu LL, Xu YY, Chen YQ, Li MM, Li LL, Yang JJ, Yang Y.
    Phytomedicine; 2023 Aug 01; 117():154903. PubMed ID: 37301185
    [Abstract] [Full Text] [Related]

  • 6. Compound Astragalus and Salvia miltiorrhiza extracts modulate MAPK-regulated TGF-β/Smad signaling in hepatocellular carcinoma by multi-target mechanism.
    Boye A, Wu C, Jiang Y, Wang J, Wu J, Yang X, Yang Y.
    J Ethnopharmacol; 2015 Jul 01; 169():219-28. PubMed ID: 25934513
    [Abstract] [Full Text] [Related]

  • 7. Smad3 gene C-terminal phosphorylation site mutation exacerbates CCl4-induced hepatic fibrogenesis by promoting pSmad2L/C-mediated signaling transduction.
    Yang J, Gong Y, Xu W, Li L, Shi Z, Wang Q, He Y, Zhang C, Luo C, Fang Z, Yang Y.
    Naunyn Schmiedebergs Arch Pharmacol; 2021 Aug 01; 394(8):1779-1786. PubMed ID: 34191114
    [Abstract] [Full Text] [Related]

  • 8. Compound Astragalus and Salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating transforming growth factor-β/Smad signaling.
    Hu X, Rui W, Wu C, He S, Jiang J, Zhang X, Yang Y.
    J Gastroenterol Hepatol; 2014 Jun 01; 29(6):1284-91. PubMed ID: 24329763
    [Abstract] [Full Text] [Related]

  • 9. Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
    Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K.
    Hepatology; 2009 Apr 01; 49(4):1203-17. PubMed ID: 19263472
    [Abstract] [Full Text] [Related]

  • 10. Activation of Nrf2/AREs-mediated antioxidant signalling, and suppression of profibrotic TGF-β1/Smad3 pathway: a promising therapeutic strategy for hepatic fibrosis - A review.
    Gong Y, Yang Y.
    Life Sci; 2020 Sep 01; 256():117909. PubMed ID: 32512009
    [Abstract] [Full Text] [Related]

  • 11. Smad3 C-terminal phosphorylation site mutation attenuates the hepatoprotective effect of salvianolic acid B against hepatocarcinogenesis.
    Gong Y, Li D, Li L, Yang J, Ding H, Zhang C, Wen G, Wu C, Fang Z, Hou S, Yang Y.
    Food Chem Toxicol; 2021 Jan 01; 147():111912. PubMed ID: 33290806
    [Abstract] [Full Text] [Related]

  • 12. Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21(WAF1) pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells.
    Li Q, Liu G, Yuan H, Wang J, Guo Y, Chen T, Zhai R, Shao D, Ni W, Tai G.
    Oncotarget; 2015 Feb 28; 6(6):4253-65. PubMed ID: 25714018
    [Abstract] [Full Text] [Related]

  • 13. Salvianolic acid B exerts an anti-hepatocellular carcinoma effect by regulating the Hippo/YAP pathway and promoting pSmad3L to pSmad3C simultaneously.
    Xu W, Shi Z, Yu X, Xu Y, Chen Y, He Y, Gong Y, Huang C, Tan C, Yang Y.
    Eur J Pharmacol; 2023 Jan 15; 939():175423. PubMed ID: 36509132
    [Abstract] [Full Text] [Related]

  • 14. Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma.
    Matsuzaki K, Murata M, Yoshida K, Sekimoto G, Uemura Y, Sakaida N, Kaibori M, Kamiyama Y, Nishizawa M, Fujisawa J, Okazaki K, Seki T.
    Hepatology; 2007 Jul 15; 46(1):48-57. PubMed ID: 17596875
    [Abstract] [Full Text] [Related]

  • 15. Synergistic anti-liver fibrosis actions of total astragalus saponins and glycyrrhizic acid via TGF-β1/Smads signaling pathway modulation.
    Zhou Y, Tong X, Ren S, Wang X, Chen J, Mu Y, Sun M, Chen G, Zhang H, Liu P.
    J Ethnopharmacol; 2016 Aug 22; 190():83-90. PubMed ID: 27282665
    [Abstract] [Full Text] [Related]

  • 16. Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription.
    Rui W, Xie L, Liu X, He S, Wu C, Zhang X, Zhang L, Yang Y.
    J Ethnopharmacol; 2014 Aug 22; 151(1):198-209. PubMed ID: 24247078
    [Abstract] [Full Text] [Related]

  • 17. Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of oxidative stress and inflammation.
    Mahmoud AM, Mohammed HM, Khadrawy SM, Galaly SR.
    Chem Biol Interact; 2017 Nov 01; 277():146-158. PubMed ID: 28935427
    [Abstract] [Full Text] [Related]

  • 18. Smad3 and its phosphoisoforms are prognostic predictors of hepatocellular carcinoma after curative hepatectomy.
    Kim SH, Ahn S, Park CK.
    Hepatobiliary Pancreat Dis Int; 2012 Feb 01; 11(1):51-9. PubMed ID: 22251470
    [Abstract] [Full Text] [Related]

  • 19. Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer.
    Matsuzaki K, Kitano C, Murata M, Sekimoto G, Yoshida K, Uemura Y, Seki T, Taketani S, Fujisawa J, Okazaki K.
    Cancer Res; 2009 Jul 01; 69(13):5321-30. PubMed ID: 19531654
    [Abstract] [Full Text] [Related]

  • 20. Interaction of microRNA-21/145 and Smad3 domain-specific phosphorylation in hepatocellular carcinoma.
    Wang JY, Fang M, Boye A, Wu C, Wu JJ, Ma Y, Hou S, Kan Y, Yang Y.
    Oncotarget; 2017 Oct 17; 8(49):84958-84973. PubMed ID: 29156696
    [Abstract] [Full Text] [Related]

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