These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

225 related items for PubMed ID: 34214842

  • 1. Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents.
    Tan H, Liu Y, Gong C, Zhang J, Huang J, Zhang Q.
    Eur J Med Chem; 2021 Nov 05; 223():113670. PubMed ID: 34214842
    [Abstract] [Full Text] [Related]

  • 2. Discovery of 7H-pyrrolo[2,3-d]pyridine derivatives as potent FAK inhibitors: Design, synthesis, biological evaluation and molecular docking study.
    Wang R, Zhao X, Yu S, Chen Y, Cui H, Wu T, Hao C, Zhao D, Cheng M.
    Bioorg Chem; 2020 Sep 05; 102():104092. PubMed ID: 32707280
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis and biological evaluation of novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potential FAK inhibitors and anticancer agents.
    Wang R, Chen Y, Zhao X, Yu S, Yang B, Wu T, Guo J, Hao C, Zhao D, Cheng M.
    Eur J Med Chem; 2019 Dec 01; 183():111716. PubMed ID: 31550660
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and biological evaluation of 7-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer.
    Wei W, Feng Z, Liu Z, Li X, He H, Ran K, Shi Y, Zhu Y, Ye T, Gao C, Wang N, Yu L.
    Eur J Med Chem; 2022 Jan 15; 228():113978. PubMed ID: 34810020
    [Abstract] [Full Text] [Related]

  • 5. N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
    Gangjee A, Zaware N, Raghavan S, Yang J, Thorpe JE, Ihnat MA.
    Bioorg Med Chem; 2012 Apr 01; 20(7):2444-54. PubMed ID: 22370340
    [Abstract] [Full Text] [Related]

  • 6. Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.
    Choi HS, Wang Z, Richmond W, He X, Yang K, Jiang T, Sim T, Karanewsky D, Gu XJ, Zhou V, Liu Y, Ohmori O, Caldwell J, Gray N, He Y.
    Bioorg Med Chem Lett; 2006 Apr 15; 16(8):2173-6. PubMed ID: 16458503
    [Abstract] [Full Text] [Related]

  • 7. Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia.
    Yuan X, Chen Y, Zhang W, He J, Lei L, Tang M, Liu J, Li M, Dou C, Yang T, Yang L, Yang S, Wei Y, Peng A, Niu T, Xiang M, Ye H, Chen L.
    J Med Chem; 2019 Apr 25; 62(8):4158-4173. PubMed ID: 30939008
    [Abstract] [Full Text] [Related]

  • 8. X-ray Crystal Structure-Guided Design and Optimization of 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
    Lee Y, Kim H, Kim H, Cho HY, Jee JG, Seo KA, Son JB, Ko E, Choi HG, Kim ND, Kim I.
    J Med Chem; 2021 May 27; 64(10):6985-6995. PubMed ID: 33942608
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.
    Gangjee A, Namjoshi OA, Yu J, Ihnat MA, Thorpe JE, Warnke LA.
    Bioorg Med Chem; 2008 May 15; 16(10):5514-28. PubMed ID: 18467105
    [Abstract] [Full Text] [Related]

  • 10. Synthesis, biological evaluation, and molecular dynamics (MD) simulation studies of three novel F-18 labeled and focal adhesion kinase (FAK) targeted 5-bromo pyrimidines as radiotracers for tumor.
    Fang Y, Wang D, Xu X, Liu J, Wu A, Li X, Xue Q, Wang H, Wang H, Zhang H.
    Eur J Med Chem; 2017 Feb 15; 127():493-508. PubMed ID: 28109944
    [Abstract] [Full Text] [Related]

  • 11. Discovery of 4-(Piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine Derivatives as Akt Inhibitors.
    Liu Y, Yin Y, Zhang J, Nomie K, Zhang L, Yang D, Wang ML, Zhao G.
    Arch Pharm (Weinheim); 2016 May 15; 349(5):356-62. PubMed ID: 26991997
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase.
    Kurup S, McAllister B, Liskova P, Mistry T, Fanizza A, Stanford D, Slawska J, Keller U, Hoellein A.
    J Enzyme Inhib Med Chem; 2018 Dec 15; 33(1):74-84. PubMed ID: 29115879
    [Abstract] [Full Text] [Related]

  • 13. Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt).
    McHardy T, Caldwell JJ, Cheung KM, Hunter LJ, Taylor K, Rowlands M, Ruddle R, Henley A, de Haven Brandon A, Valenti M, Davies TG, Fazal L, Seavers L, Raynaud FI, Eccles SA, Aherne GW, Garrett MD, Collins I.
    J Med Chem; 2010 Mar 11; 53(5):2239-49. PubMed ID: 20151677
    [Abstract] [Full Text] [Related]

  • 14. Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2.
    Choi HS, Wang Z, Richmond W, He X, Yang K, Jiang T, Karanewsky D, Gu XJ, Zhou V, Liu Y, Che J, Lee CC, Caldwell J, Kanazawa T, Umemura I, Matsuura N, Ohmori O, Honda T, Gray N, He Y.
    Bioorg Med Chem Lett; 2006 May 15; 16(10):2689-92. PubMed ID: 16524731
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis and evaluation of novel 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as potent, selective and reversible Bruton's tyrosine kinase (BTK) inhibitors for the treatment of rheumatoid arthritis.
    Zhang C, Pei H, He J, Zhu J, Li W, Niu T, Xiang M, Chen L.
    Eur J Med Chem; 2019 May 01; 169():121-143. PubMed ID: 30875504
    [Abstract] [Full Text] [Related]

  • 16. Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors.
    Musumeci F, Sanna M, Grossi G, Brullo C, Fallacara AL, Schenone S.
    Curr Med Chem; 2017 May 01; 24(19):2059-2085. PubMed ID: 28266267
    [Abstract] [Full Text] [Related]

  • 17. Discovery of novel pyrrolo-pyridine/pyrimidine derivatives bearing pyridazinone moiety as c-Met kinase inhibitors.
    Wang LX, Liu X, Xu S, Tang Q, Duan Y, Xiao Z, Zhi J, Jiang L, Zheng P, Zhu W.
    Eur J Med Chem; 2017 Dec 01; 141():538-551. PubMed ID: 29107421
    [Abstract] [Full Text] [Related]

  • 18. Identification of Thieno[3,2-d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3.
    Cho H, Shin I, Yoon H, Jeon E, Lee J, Kim Y, Ryu S, Song C, Kwon NH, Moon Y, Kim S, Kim ND, Choi HG, Sim T.
    J Med Chem; 2021 Aug 26; 64(16):11934-11957. PubMed ID: 34324343
    [Abstract] [Full Text] [Related]

  • 19.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 20.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 12.