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168 related items for PubMed ID: 34232502

  • 1. Quantitative prediction of P-glycoprotein-mediated drug-drug interactions and intestinal absorption using humanized mice.
    Miyake T, Tsutsui H, Haraya K, Tachibana T, Morimoto K, Takehara S, Ayabe M, Kobayashi K, Kazuki Y.
    Br J Pharmacol; 2021 Nov; 178(21):4335-4351. PubMed ID: 34232502
    [Abstract] [Full Text] [Related]

  • 2. Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.
    Yamasaki Y, Kobayashi K, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y.
    Drug Metab Dispos; 2018 Nov; 46(11):1756-1766. PubMed ID: 29777024
    [Abstract] [Full Text] [Related]

  • 3. The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition.
    Price DF, Luscombe CN, Eddershaw PJ, Edwards CD, Gumbleton M.
    Pharm Res; 2017 Dec; 34(12):2498-2516. PubMed ID: 28702798
    [Abstract] [Full Text] [Related]

  • 4. Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.
    Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G.
    Pharm Res; 2004 May; 21(5):819-26. PubMed ID: 15180340
    [Abstract] [Full Text] [Related]

  • 5. P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor.
    Yang JJ, Milton MN, Yu S, Liao M, Liu N, Wu JT, Gan L, Balani SK, Lee FW, Prakash S, Xia CQ.
    Drug Metab Lett; 2010 Dec; 4(4):201-12. PubMed ID: 20670210
    [Abstract] [Full Text] [Related]

  • 6. Prediction of drug-drug interaction risk of P-glycoprotein substrate in drug discovery.
    Kido Y, Nanchi I, Matsuzaki T, Watari R, Kiyohara H, Seki N, Okuda T.
    Drug Metab Pharmacokinet; 2024 Jun; 56():101008. PubMed ID: 38663183
    [Abstract] [Full Text] [Related]

  • 7. Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney.
    Asaumi R, Nunoya KI, Yamaura Y, Taskar KS, Sugiyama Y.
    CPT Pharmacometrics Syst Pharmacol; 2022 Jul; 11(7):919-933. PubMed ID: 35570332
    [Abstract] [Full Text] [Related]

  • 8. Development of Simplified in Vitro P-Glycoprotein Substrate Assay and in Silico Prediction Models To Evaluate Transport Potential of P-Glycoprotein.
    Ohashi R, Watanabe R, Esaki T, Taniguchi T, Torimoto-Katori N, Watanabe T, Ogasawara Y, Takahashi T, Tsukimoto M, Mizuguchi K.
    Mol Pharm; 2019 May 06; 16(5):1851-1863. PubMed ID: 30933526
    [Abstract] [Full Text] [Related]

  • 9. Evaluation of the Role of P-glycoprotein (P-gp)-Mediated Efflux in the Intestinal Absorption of Common Substrates with Elacridar, a P-gp Inhibitor, in Rats.
    Suzuki K, Taniyama K, Aoyama T, Watanabe Y.
    Eur J Drug Metab Pharmacokinet; 2020 Jun 06; 45(3):385-392. PubMed ID: 32078103
    [Abstract] [Full Text] [Related]

  • 10. Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice.
    Marchetti S, de Vries NA, Buckle T, Bolijn MJ, van Eijndhoven MA, Beijnen JH, Mazzanti R, van Tellingen O, Schellens JH.
    Mol Cancer Ther; 2008 Aug 06; 7(8):2280-7. PubMed ID: 18723475
    [Abstract] [Full Text] [Related]

  • 11. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
    Ye D, Harder A, Fang Z, Weinheimer M, Laplanche L, Mezler M.
    Pharm Res; 2020 Sep 11; 37(10):194. PubMed ID: 32918191
    [Abstract] [Full Text] [Related]

  • 12. Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice.
    Stephens RH, O'Neill CA, Bennett J, Humphrey M, Henry B, Rowland M, Warhurst G.
    Br J Pharmacol; 2002 Apr 11; 135(8):2038-46. PubMed ID: 11959808
    [Abstract] [Full Text] [Related]

  • 13. Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro.
    Adachi Y, Suzuki H, Sugiyama Y.
    Pharm Res; 2003 Aug 11; 20(8):1163-9. PubMed ID: 12948013
    [Abstract] [Full Text] [Related]

  • 14. Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport.
    Sadiq MW, Uchida Y, Hoshi Y, Tachikawa M, Terasaki T, Hammarlund-Udenaes M.
    PLoS One; 2015 Aug 11; 10(5):e0118638. PubMed ID: 25932627
    [Abstract] [Full Text] [Related]

  • 15. Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats.
    Zhang H, Yao M, Morrison RA, Chong S.
    Arch Pharm Res; 2003 Sep 11; 26(9):768-72. PubMed ID: 14560928
    [Abstract] [Full Text] [Related]

  • 16. Ex vivo and in vivo investigations of the effects of extracts of Vernonia amygdalina, Carica papaya and Tapinanthus sessilifolius on digoxin transport and pharmacokinetics: assessing the significance on rat intestinal P-glycoprotein efflux.
    Oga EF, Sekine S, Horie T.
    Drug Metab Pharmacokinet; 2013 Sep 11; 28(4):314-20. PubMed ID: 23291634
    [Abstract] [Full Text] [Related]

  • 17. In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect.
    Tubic M, Wagner D, Spahn-Langguth H, Bolger MB, Langguth P.
    Pharm Res; 2006 Aug 11; 23(8):1712-20. PubMed ID: 16832615
    [Abstract] [Full Text] [Related]

  • 18. Prediction of nonlinear intestinal absorption of CYP3A4 and P-glycoprotein substrates from their in vitro Km values.
    Tachibana T, Kato M, Sugiyama Y.
    Pharm Res; 2012 Mar 11; 29(3):651-68. PubMed ID: 21913031
    [Abstract] [Full Text] [Related]

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  • 20. Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures.
    Venkatakrishnan K, Tseng E, Nelson FR, Rollema H, French JL, Kaplan IV, Horner WE, Gibbs MA.
    Drug Metab Dispos; 2007 Aug 11; 35(8):1341-9. PubMed ID: 17470526
    [Abstract] [Full Text] [Related]

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