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Journal Abstract Search

206 related items for PubMed ID: 34234118

  • 1.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 2. Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
    Pfister SX, Markkanen E, Jiang Y, Sarkar S, Woodcock M, Orlando G, Mavrommati I, Pai CC, Zalmas LP, Drobnitzky N, Dianov GL, Verrill C, Macaulay VM, Ying S, La Thangue NB, D'Angiolella V, Ryan AJ, Humphrey TC.
    Cancer Cell; 2015 Nov 09; 28(5):557-568. PubMed ID: 26602815
    [Abstract] [Full Text] [Related]

  • 3. CREB1 directly activates the transcription of ribonucleotide reductase small subunit M2 and promotes the aggressiveness of human colorectal cancer.
    Fang Z, Lin A, Chen J, Zhang X, Liu H, Li H, Hu Y, Zhang X, Zhang J, Qiu L, Mei L, Shao J, Chen X.
    Oncotarget; 2016 Nov 22; 7(47):78055-78068. PubMed ID: 27801665
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of the ATR-CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2.
    Koppenhafer SL, Goss KL, Terry WW, Gordon DJ.
    Mol Cancer Res; 2020 Jan 22; 18(1):91-104. PubMed ID: 31649026
    [Abstract] [Full Text] [Related]

  • 5. E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma.
    Liu K, Wang L, Lou Z, Guo L, Xu Y, Qi H, Fang Z, Mei L, Chen X, Zhang X, Shao J, Xiang X.
    Biochem Pharmacol; 2023 Dec 22; 218():115854. PubMed ID: 37863324
    [Abstract] [Full Text] [Related]

  • 6. E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide reductase small subunit M2.
    Fang Z, Gong C, Liu H, Zhang X, Mei L, Song M, Qiu L, Luo S, Zhu Z, Zhang R, Gu H, Chen X.
    Biochem Biophys Res Commun; 2015 Aug 21; 464(2):407-15. PubMed ID: 26093293
    [Abstract] [Full Text] [Related]

  • 7. Antitumor effect of WEE1 blockade as monotherapy or in combination with cisplatin in urothelial cancer.
    Murakami K, Kita Y, Sakatani T, Hamada A, Mizuno K, Nakamura K, Takada H, Matsumoto K, Sano T, Goto T, Akamatsu S, Saito R, Tsuruyama T, Ogawa O, Kobayashi T.
    Cancer Sci; 2021 Sep 21; 112(9):3669-3681. PubMed ID: 34212455
    [Abstract] [Full Text] [Related]

  • 8. A Novel Mechanism Driving Poor-Prognosis Prostate Cancer: Overexpression of the DNA Repair Gene, Ribonucleotide Reductase Small Subunit M2 (RRM2).
    Mazzu YZ, Armenia J, Chakraborty G, Yoshikawa Y, Coggins SA, Nandakumar S, Gerke TA, Pomerantz MM, Qiu X, Zhao H, Atiq M, Khan N, Komura K, Lee GM, Fine SW, Bell C, O'Connor E, Long HW, Freedman ML, Kim B, Kantoff PW.
    Clin Cancer Res; 2019 Jul 15; 25(14):4480-4492. PubMed ID: 30996073
    [Abstract] [Full Text] [Related]

  • 9. Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy.
    Guertin AD, Li J, Liu Y, Hurd MS, Schuller AG, Long B, Hirsch HA, Feldman I, Benita Y, Toniatti C, Zawel L, Fawell SE, Gilliland DG, Shumway SD.
    Mol Cancer Ther; 2013 Aug 15; 12(8):1442-52. PubMed ID: 23699655
    [Abstract] [Full Text] [Related]

  • 10. GL-V9 synergizes with oxaliplatin of colorectal cancer via Wee1 degradation mediated by HSP90 inhibition.
    Chen H, Yang F, Zhao Q, Wang H, Zhu M, Li H, Ge Z, Zhang S, Guo Q, Hui H.
    J Pharm Pharmacol; 2024 Aug 02; 76(8):1006-1017. PubMed ID: 38767973
    [Abstract] [Full Text] [Related]

  • 11. Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response.
    Zhang YW, Jones TL, Martin SE, Caplen NJ, Pommier Y.
    J Biol Chem; 2009 Jul 03; 284(27):18085-95. PubMed ID: 19416980
    [Abstract] [Full Text] [Related]

  • 12. WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
    Guo E, Xiao R, Wu Y, Lu F, Liu C, Yang B, Li X, Fu Y, Wang Z, Li Y, Huang Y, Li F, Wu X, You L, Qin T, Lu Y, Huang X, Ma D, Mills GB, Sun C, Chen G.
    J Exp Med; 2022 Jan 03; 219(1):. PubMed ID: 34825915
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of ribonucleotide reductase subunit M2 enhances the radiosensitivity of metastatic pancreatic neuroendocrine tumor.
    Chow Z, Johnson J, Chauhan A, Jeong JC, Castle JT, Izumi T, Weiss H, Townsend CM, Schrader J, Anthony L, Yang ES, Evers BM, Rychahou P.
    Cancer Lett; 2024 Aug 01; 596():216993. PubMed ID: 38801884
    [Abstract] [Full Text] [Related]

  • 14. Osalmid, a Novel Identified RRM2 Inhibitor, Enhances Radiosensitivity of Esophageal Cancer.
    Tang Q, Wu L, Xu M, Yan D, Shao J, Yan S.
    Int J Radiat Oncol Biol Phys; 2020 Dec 01; 108(5):1368-1379. PubMed ID: 32763454
    [Abstract] [Full Text] [Related]

  • 15. Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress.
    Young LA, O'Connor LO, de Renty C, Veldman-Jones MH, Dorval T, Wilson Z, Jones DR, Lawson D, Odedra R, Maya-Mendoza A, Reimer C, Bartek J, Lau A, O'Connor MJ.
    Cancer Res; 2019 Jul 15; 79(14):3762-3775. PubMed ID: 31123088
    [Abstract] [Full Text] [Related]

  • 16. Emerging roles of the ribonucleotide reductase M2 in colorectal cancer and ultraviolet-induced DNA damage repair.
    Lu AG, Feng H, Wang PX, Han DP, Chen XH, Zheng MH.
    World J Gastroenterol; 2012 Sep 14; 18(34):4704-13. PubMed ID: 23002339
    [Abstract] [Full Text] [Related]

  • 17. The lncRNA XIST/miR-125b-2-3p axis modulates cell proliferation and chemotherapeutic sensitivity via targeting Wee1 in colorectal cancer.
    Zeng ZL, Lu JH, Wang Y, Sheng H, Wang YN, Chen ZH, Wu QN, Zheng JB, Chen YX, Yang DD, Yu K, Mo HY, Hu JJ, Hu PS, Liu ZX, Ju HQ, Xu RH.
    Cancer Med; 2021 Apr 14; 10(7):2423-2441. PubMed ID: 33666372
    [Abstract] [Full Text] [Related]

  • 18. Sequential combination of bortezomib and WEE1 inhibitor, MK-1775, induced apoptosis in multiple myeloma cell lines.
    Barbosa RSS, Dantonio PM, Guimarães T, de Oliveira MB, Fook Alves VL, Sandes AF, Fernando RC, Colleoni GWB.
    Biochem Biophys Res Commun; 2019 Nov 12; 519(3):597-604. PubMed ID: 31540690
    [Abstract] [Full Text] [Related]

  • 19. Ribonucleotide reductase subunit M2 promotes proliferation and epithelial-mesenchymal transition via the JAK2/STAT3 signaling pathway in retinoblastoma.
    Yang M, Yao P, Lang X, Li X, Zhang D.
    Bioengineered; 2021 Dec 12; 12(2):12800-12811. PubMed ID: 34895038
    [Abstract] [Full Text] [Related]

  • 20. MicroRNA-20a-5p suppresses tumor angiogenesis of non-small cell lung cancer through RRM2-mediated PI3K/Akt signaling pathway.
    Han J, Hu J, Sun F, Bian H, Tang B, Fang X.
    Mol Cell Biochem; 2021 Feb 12; 476(2):689-698. PubMed ID: 33125611
    [Abstract] [Full Text] [Related]

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