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Journal Abstract Search

129 related items for PubMed ID: 34251799

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  • 4. Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease.
    Yahiaoui S, Hamidouche K, Ballandonne C, Davis A, de Oliveira Santos JS, Freret T, Boulouard M, Rochais C, Dallemagne P.
    Eur J Med Chem; 2016 Oct 04; 121():283-293. PubMed ID: 27266998
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  • 5. Usmarapride (SUVN-D4010), a 5-HT4 receptor partial agonist for the potential treatment of Alzheimer's disease: Behavioural, neurochemical and pharmacological profiling.
    Nirogi R, Grandhi VR, Medapati R, Ganuga N, Abraham R, Thentu JB, Palacharla VRC, Petlu S, Srirangavaram M, Subramanian R, Ravella SR, Gagginapally SR, Benade V, Jayarajan P, Mohammed AR.
    Eur J Pharmacol; 2023 May 15; 947():175625. PubMed ID: 36997046
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  • 6. Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease.
    Brodney MA, Johnson DE, Sawant-Basak A, Coffman KJ, Drummond EM, Hudson EL, Fisher KE, Noguchi H, Waizumi N, McDowell LL, Papanikolaou A, Pettersen BA, Schmidt AW, Tseng E, Stutzman-Engwall K, Rubitski DM, Vanase-Frawley MA, Grimwood S.
    J Med Chem; 2012 Nov 08; 55(21):9240-54. PubMed ID: 22974325
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  • 8. Synthesis and structure-activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold.
    Castriconi F, Paolino M, Giuliani G, Anzini M, Campiani G, Mennuni L, Sabatini C, Lanza M, Caselli G, De Rienzo F, Menziani MC, Sbraccia M, Molinari P, Costa T, Cappelli A.
    Eur J Med Chem; 2014 Jul 23; 82():36-46. PubMed ID: 24871995
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  • 13. 5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment.
    Shen F, Smith JA, Chang R, Bourdet DL, Tsuruda PR, Obedencio GP, Beattie DT.
    Neuropharmacology; 2011 Jul 23; 61(1-2):69-79. PubMed ID: 21392515
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  • 15. New insights into serotonin 5-HT4 receptors : a novel therapeutic target for Alzheimer's disease?
    Maillet M, Robert SJ, Lezoualc'h F.
    Curr Alzheimer Res; 2004 May 23; 1(2):79-85. PubMed ID: 15975071
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  • 16. Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease.
    Russo O, Cachard-Chastel M, Rivière C, Giner M, Soulier JL, Berthouze M, Richard T, Monti JP, Sicsic S, Lezoualc'h F, Berque-Bestel I.
    J Med Chem; 2009 Apr 23; 52(8):2214-25. PubMed ID: 19334715
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  • 18. Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT(4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation.
    Long DD, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Genov D, Goldblum AA, Humphrey PP, Jiang L, Marquess DG, Shaw JP, Smith JA, Turner SD, Vickery RG.
    Bioorg Med Chem Lett; 2012 Oct 01; 22(19):6048-52. PubMed ID: 22959244
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  • 19. Understanding the Molecular Basis of 5-HT4 Receptor Partial Agonists through 3D-QSAR Studies.
    Castro-Alvarez A, Chávez-Ángel E, Nelson R.
    Int J Mol Sci; 2021 Mar 30; 22(7):. PubMed ID: 33808456
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