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128 related items for PubMed ID: 34257831

  • 1. Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate.
    Bobiļeva O, Bobrovs R, Kaņepe I, Patetko L, Kalniņš G, Šišovs M, Bula AL, Gri Nberga S, Borodušķis MR, Ramata-Stunda A, Rostoks N, Jirgensons A, Ta Rs K, Jaudzems K.
    ACS Med Chem Lett; 2021 Jul 08; 12(7):1102-1107. PubMed ID: 34257831
    [Abstract] [Full Text] [Related]

  • 2. Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening.
    Bobrovs R, Kanepe I, Narvaiss N, Patetko L, Kalnins G, Sisovs M, Bula AL, Grinberga S, Boroduskis M, Ramata-Stunda A, Rostoks N, Jirgensons A, Tars K, Jaudzems K.
    Pharmaceuticals (Basel); 2021 Nov 30; 14(12):. PubMed ID: 34959647
    [Abstract] [Full Text] [Related]

  • 3. Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase.
    Ahmed-Belkacem R, Sutto-Ortiz P, Guiraud M, Canard B, Vasseur JJ, Decroly E, Debart F.
    Eur J Med Chem; 2020 Sep 01; 201():112557. PubMed ID: 32563813
    [Abstract] [Full Text] [Related]

  • 4. Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.
    Aouadi W, Blanjoie A, Vasseur JJ, Debart F, Canard B, Decroly E.
    J Virol; 2017 Mar 01; 91(5):. PubMed ID: 28031370
    [Abstract] [Full Text] [Related]

  • 5. Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
    Kottur J, White KM, Rodriguez ML, Rechkoblit O, Quintana-Feliciano R, Nayar A, García-Sastre A, Aggarwal AK.
    PLoS Pathog; 2023 Jul 01; 19(7):e1011546. PubMed ID: 37523415
    [Abstract] [Full Text] [Related]

  • 6. Computational Analysis of SAM Analogs as Methyltransferase Inhibitors of nsp16/nsp10 Complex from SARS-CoV-2.
    Balieiro AM, Anunciação ELS, Costa CHS, Qayed WS, Silva JRA.
    Int J Mol Sci; 2022 Nov 12; 23(22):. PubMed ID: 36430451
    [Abstract] [Full Text] [Related]

  • 7. Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases.
    Hausdorff M, Delpal A, Barelier S, Nicollet L, Canard B, Touret F, Colmant A, Coutard B, Vasseur JJ, Decroly E, Debart F.
    Eur J Med Chem; 2023 Aug 05; 256():115474. PubMed ID: 37192550
    [Abstract] [Full Text] [Related]

  • 8. Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.
    Klima M, Khalili Yazdi A, Li F, Chau I, Hajian T, Bolotokova A, Kaniskan HÜ, Han Y, Wang K, Li D, Luo M, Jin J, Boura E, Vedadi M.
    Protein Sci; 2022 Sep 05; 31(9):e4395. PubMed ID: 36040262
    [Abstract] [Full Text] [Related]

  • 9. A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases.
    Samrat SK, Bashir Q, Zhang R, Huang Y, Liu Y, Wu X, Brown T, Wang W, Zheng YG, Zhang QY, Chen Y, Li Z, Li H.
    Emerg Microbes Infect; 2023 Dec 05; 12(1):2204164. PubMed ID: 37060263
    [Abstract] [Full Text] [Related]

  • 10. 3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors.
    Bobileva O, Bobrovs R, Sirma EE, Kanepe I, Bula AL, Patetko L, Ramata-Stunda A, Grinberga S, Jirgensons A, Jaudzems K.
    Molecules; 2023 Jan 12; 28(2):. PubMed ID: 36677825
    [Abstract] [Full Text] [Related]

  • 11. Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues.
    Ahmed-Belkacem R, Hausdorff M, Delpal A, Sutto-Ortiz P, Colmant AMG, Touret F, Ogando NS, Snijder EJ, Canard B, Coutard B, Vasseur JJ, Decroly E, Debart F.
    J Med Chem; 2022 Apr 28; 65(8):6231-6249. PubMed ID: 35439007
    [Abstract] [Full Text] [Related]

  • 12. The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors.
    Otava T, Šála M, Li F, Fanfrlík J, Devkota K, Perveen S, Chau I, Pakarian P, Hobza P, Vedadi M, Boura E, Nencka R.
    ACS Infect Dis; 2021 Aug 13; 7(8):2214-2220. PubMed ID: 34152728
    [Abstract] [Full Text] [Related]

  • 13. 5'-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2'-O-methyltransferases.
    Ahmed-Belkacem R, Sutto-Ortiz P, Delpal A, Troussier J, Canard B, Vasseur JJ, Decroly E, Debart F.
    Bioorg Chem; 2024 Feb 13; 143():107035. PubMed ID: 38199140
    [Abstract] [Full Text] [Related]

  • 14. N-Arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2.
    Ahmed-Belkacem R, Troussier J, Delpal A, Canard B, Vasseur JJ, Decroly E, Debart F.
    RSC Med Chem; 2024 Mar 20; 15(3):839-847. PubMed ID: 38516599
    [Abstract] [Full Text] [Related]

  • 15. Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
    Coutard B, Barral K, Lichière J, Selisko B, Martin B, Aouadi W, Lombardia MO, Debart F, Vasseur JJ, Guillemot JC, Canard B, Decroly E.
    J Virol; 2017 Mar 01; 91(5):. PubMed ID: 28031359
    [Abstract] [Full Text] [Related]

  • 16. SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases.
    Zhang J, Zheng YG.
    ACS Chem Biol; 2016 Mar 18; 11(3):583-97. PubMed ID: 26540123
    [Abstract] [Full Text] [Related]

  • 17. Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
    Kalnins G, Rudusa L, Bula AL, Zelencova-Gopejenko D, Bobileva O, Sisovs M, Tars K, Jirgensons A, Jaudzems K, Bobrovs R.
    ChemMedChem; 2024 Dec 16; 19(24):e202400618. PubMed ID: 39258386
    [Abstract] [Full Text] [Related]

  • 18. Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors.
    Štefek M, Chalupská D, Chalupský K, Zgarbová M, Dvořáková A, Krafčíková P, Li ASM, Šála M, Dejmek M, Otava T, Chaloupecká E, Kozák J, Kozic J, Vedadi M, Weber J, Mertlíková-Kaiserová H, Nencka R.
    ACS Omega; 2023 Aug 01; 8(30):27410-27418. PubMed ID: 37546609
    [Abstract] [Full Text] [Related]

  • 19. Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39.
    Zilecka E, Klima M, Stefek M, Dejmek M, Nencka R, Boura E.
    J Struct Biol X; 2024 Dec 01; 10():100109. PubMed ID: 39188530
    [Abstract] [Full Text] [Related]

  • 20. Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales.
    Zeng C, Wu A, Wang Y, Xu S, Tang Y, Jin X, Wang S, Qin L, Sun Y, Fan C, Snijder EJ, Neuman BW, Chen Y, Ahola T, Guo D.
    J Virol; 2016 Aug 01; 90(15):6675-6685. PubMed ID: 27170751
    [Abstract] [Full Text] [Related]

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