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182 related items for PubMed ID: 34378386

  • 1. Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
    Chen H, Deng S, Albadari N, Yun MK, Zhang S, Li Y, Ma D, Parke DN, Yang L, Seagroves TN, White SW, Miller DD, Li W.
    J Med Chem; 2021 Aug 26; 64(16):12049-12074. PubMed ID: 34378386
    [Abstract] [Full Text] [Related]

  • 2. Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.
    Li Y, Liu Y, Zhu Z, Yan W, Zhang C, Yang Z, Bai P, Tang M, Shi M, He W, Fu S, Liu J, Han K, Li J, Xie L, Ye H, Yang J, Chen L.
    J Med Chem; 2022 Feb 10; 65(3):2675-2693. PubMed ID: 35084853
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
    Gao F, Liang Y, Zhou P, Cheng J, Ding K, Wang Y.
    Eur J Med Chem; 2019 Sep 15; 178():177-194. PubMed ID: 31185410
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors.
    Wang G, Peng F, Cao D, Yang Z, Han X, Liu J, Wu W, He L, Ma L, Chen J, Sang Y, Xiang M, Peng A, Wei Y, Chen L.
    Bioorg Med Chem; 2013 Nov 01; 21(21):6844-54. PubMed ID: 23993668
    [Abstract] [Full Text] [Related]

  • 5. Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure.
    Wang L, Zheng Y, Li D, Yang J, Lei L, Yan W, Zheng W, Tang M, Shi M, Zhang R, Cai X, Ni H, Ma X, Li N, Hong F, Ye H, Chen L.
    J Med Chem; 2021 Jun 24; 64(12):8127-8141. PubMed ID: 34081857
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors.
    Shuai W, Li X, Li W, Xu F, Lu L, Yao H, Yang L, Zhu H, Xu S, Zhu Z, Xu J.
    Eur J Med Chem; 2020 Jul 01; 197():112308. PubMed ID: 32339853
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.
    Lai Q, Wang Y, Wang R, Lai W, Tang L, Tao Y, Liu Y, Zhang R, Huang L, Xiang H, Zeng S, Gou L, Chen H, Yao Y, Yang J.
    Eur J Med Chem; 2018 Aug 05; 156():162-179. PubMed ID: 30006162
    [Abstract] [Full Text] [Related]

  • 8. Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site.
    Li W, Sun H, Xu F, Shuai W, Liu J, Xu S, Yao H, Ma C, Zhu Z, Xu J.
    Bioorg Chem; 2019 Apr 05; 85():49-59. PubMed ID: 30599412
    [Abstract] [Full Text] [Related]

  • 9. Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study.
    Ma W, Chen P, Huo X, Ma Y, Li Y, Diao P, Yang F, Zheng S, Hu M, You W, Zhao P.
    Eur J Med Chem; 2020 Dec 15; 208():112847. PubMed ID: 33022479
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.
    Li G, Wang Y, Li L, Ren Y, Deng X, Liu J, Wang W, Luo M, Liu S, Chen J.
    Eur J Med Chem; 2020 Sep 15; 202():112519. PubMed ID: 32650183
    [Abstract] [Full Text] [Related]

  • 11. Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer.
    Oluwalana D, Adeleye KL, Krutilina RI, Chen H, Playa H, Deng S, Parke DN, Abernathy J, Middleton L, Cullom A, Thalluri B, Ma D, Meibohm B, Miller DD, Seagroves TN, Li W.
    Cancer Lett; 2024 Aug 10; 597():217011. PubMed ID: 38849011
    [Abstract] [Full Text] [Related]

  • 12. Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
    Chen H, Deng S, Wang Y, Albadari N, Kumar G, Ma D, Li W, White SW, Miller DD, Li W.
    J Med Chem; 2020 Jan 23; 63(2):827-846. PubMed ID: 31860298
    [Abstract] [Full Text] [Related]

  • 13. Discovery of a chiral fluorinated azetidin-2-one as a tubulin polymerisation inhibitor with potent antitumour efficacy.
    Tang H, Cheng J, Liang Y, Wang Y.
    Eur J Med Chem; 2020 Jul 01; 197():112323. PubMed ID: 32339854
    [Abstract] [Full Text] [Related]

  • 14. (E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides as tubulin polymerization inhibitors: Structure-based bioisosterism design, synthesis, biological evaluation, molecular docking and in silico ADME prediction.
    Wang G, Peng Z, Peng S, Qiu J, Li Y, Lan Y.
    Bioorg Med Chem Lett; 2018 Nov 01; 28(20):3350-3355. PubMed ID: 30197030
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis and biological evaluation of benz-fused five-membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities.
    Komuraiah B, Ren Y, Xue M, Cheng B, Liu J, Liu Y, Chen J.
    Chem Biol Drug Des; 2021 May 01; 97(5):1109-1116. PubMed ID: 33638903
    [Abstract] [Full Text] [Related]

  • 16. Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain.
    Li W, Yin Y, Shuai W, Xu F, Yao H, Liu J, Cheng K, Xu J, Zhu Z, Xu S.
    Bioorg Chem; 2019 Mar 01; 83():380-390. PubMed ID: 30408650
    [Abstract] [Full Text] [Related]

  • 17. Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities.
    Zhu H, Li W, Shuai W, Liu Y, Yang L, Tan Y, Zheng T, Yao H, Xu J, Zhu Z, Yang DH, Chen ZS, Xu S.
    Eur J Med Chem; 2021 Apr 15; 216():113316. PubMed ID: 33676300
    [Abstract] [Full Text] [Related]

  • 18. Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities.
    Ren Y, Wang Y, Li G, Zhang Z, Ma L, Cheng B, Chen J.
    J Med Chem; 2021 Apr 22; 64(8):4498-4515. PubMed ID: 33788562
    [Abstract] [Full Text] [Related]

  • 19. Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
    Liu YN, Wang JJ, Ji YT, Zhao GD, Tang LQ, Zhang CM, Guo XL, Liu ZP.
    J Med Chem; 2016 Jun 09; 59(11):5341-55. PubMed ID: 27172319
    [Abstract] [Full Text] [Related]

  • 20. Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance.
    Cheng B, Zhu G, Meng L, Wu G, Chen Q, Ma S.
    Eur J Med Chem; 2022 Jan 15; 228():113930. PubMed ID: 34794817
    [Abstract] [Full Text] [Related]

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