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Journal Abstract Search

127 related items for PubMed ID: 3445290

  • 1. Synthesis of 3 beta-hydroxy-5 alpha-cholest-8-en-7-one and 3 beta-hydroxy-5 alpha-cholest-8-en-11-one: evaluation as potential hypocholesterolemic agents.
    Parish EJ, Nanduri VB, Seikel JM, Kohl HH, Nusbaum KE.
    Steroids; 1986; 48(5-6):407-18. PubMed ID: 3445290
    [Abstract] [Full Text] [Related]

  • 2. Crystal structure of 3 beta-benzoyloxy-6 alpha-chloro-5 alpha-cholest-7-ene, a key intermediate in the chemical synthesis of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one.
    Wilson DK, Wilson WK, Quiocho FA, Schroepfer GJ.
    Chem Phys Lipids; 1988 Aug; 47(4):283-9. PubMed ID: 3191560
    [Abstract] [Full Text] [Related]

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  • 4. Inhibitors of sterol synthesis. Metabolism-based design and construction of a new analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and its effects in cultured mammalian cells and in rats.
    Swaminathan S, Siddiqui AU, Gerst N, Pinkerton FD, Kisic A, Kim LJ, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1995 Apr; 36(4):767-86. PubMed ID: 7616123
    [Abstract] [Full Text] [Related]

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  • 6. Inhibitors of sterol synthesis. The effects of dietary 5 alpha-cholest-8(14)-en-3 beta-ol-15-one on the fate of [4-14C]cholesterol and [2,4-3H]5 alpha-cholest-8(14)-en-3 beta-ol-15-one after intragastric administration to rats.
    Brabson JS, Schroepfer GJ.
    Chem Phys Lipids; 1988 May; 47(1):1-20. PubMed ID: 3396132
    [Abstract] [Full Text] [Related]

  • 7. Concerning the structure of 3 beta-benzoyloxy-5 beta-cholesta-8,14-diene, a major byproduct in the chemical synthesis of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one.
    Wilson DK, Wilson WK, Quiocho FA, Schroepfer GJ.
    Chem Phys Lipids; 1988 Aug; 47(4):273-82. PubMed ID: 3191559
    [Abstract] [Full Text] [Related]

  • 8. Concerning the chemical synthesis of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one, a novel regulator of cholesterol metabolism.
    Wilson WK, Wang KS, Kisic A, Schroepfer GJ.
    Chem Phys Lipids; 1988 Sep; 48(1-2):7-17. PubMed ID: 3208416
    [Abstract] [Full Text] [Related]

  • 9. Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 9 alpha-fluoro-5 alpha-cholest-8(14)-en-3 beta-ol-15-one.
    Schroepfer GJ, Walker V, Parish EJ, Kisic A.
    Biochem Biophys Res Commun; 1980 Apr 14; 93(3):813-8. PubMed ID: 7387678
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  • 10. Enzymatic formation and chemical synthesis of an active metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one, a potent regulator of cholesterol metabolism.
    Schroepfer GJ, Kim HS, Vermilion JL, Stephens TW, Pinkerton FD, Needleman DH, Wilson WK, St Pyrek J.
    Biochem Biophys Res Commun; 1988 Feb 29; 151(1):130-6. PubMed ID: 3348769
    [Abstract] [Full Text] [Related]

  • 11. Inhibitors of sterol synthesis. Morphological studies in rats after dietary administration of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent hypocholesterolemic compound.
    Smith JH, Kisic A, Diaz-Arrastia R, Pelley RP, Schroepfer GJ.
    Toxicol Pathol; 1989 Feb 29; 17(3):506-15. PubMed ID: 2814226
    [Abstract] [Full Text] [Related]

  • 12. Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 5alpha-cholest-8(14)-en-3beta-ol-15-one in rats and mice.
    Schroepfer GJ, Monger D, Taylor AS, Chamberlain JS, Parish EJ, Kisic A, Kandutsch AA.
    Biochem Biophys Res Commun; 1977 Oct 24; 78(4):1227-33. PubMed ID: 921774
    [No Abstract] [Full Text] [Related]

  • 13. Inhibitors of sterol synthesis. Concerning the structure of 15 beta-methyl-5 alpha,14 beta-cholest-7-ene-3 beta,15 alpha-diol, an inhibitor of cholesterol biosynthesis.
    Bowen ST, Parish EJ, Wilson WK, Schroepfer GJ, Quiocho FA.
    Chem Phys Lipids; 1988 Apr 24; 46(4):245-51. PubMed ID: 3365828
    [Abstract] [Full Text] [Related]

  • 14. Inhibitors of sterol synthesis: synthesis and spectral properties of derivatives of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one fluorinated at carbon 7 or carbon 9 and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Siddiqui AU, Swaminathan S, Pinkerton FD, Gerst N, Wilson WK, Choi H, Schroephfer GJ.
    Chem Phys Lipids; 1994 Jun 24; 72(1):59-75. PubMed ID: 7923480
    [Abstract] [Full Text] [Related]

  • 15. Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholesta-8(14),24-dien-15-one, 3 beta,25-dihydroxy-5 alpha-cholest-8(14)-en-15-one, and 3 beta,24-dihydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Swaminathan S, Pinkerton FD, Numazawa S, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1992 Oct 24; 33(10):1503-15. PubMed ID: 1431575
    [Abstract] [Full Text] [Related]

  • 16. Inhibitors of sterol synthesis. Characterization of side chain oxygenated derivatives formed upon incubation of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one with rat liver mitochondria.
    Pyrek JS, Vermilion JL, Stephens TW, Wilson WK, Schroepfer GJ.
    J Biol Chem; 1989 Mar 15; 264(8):4536-43. PubMed ID: 2925655
    [Abstract] [Full Text] [Related]

  • 17. Inhibitors of sterol synthesis. Synthesis and spectral characterization of fatty acids esters of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one.
    St Pyrek J, Schroepfer GJ.
    J Lipid Res; 1987 Nov 15; 28(11):1308-12. PubMed ID: 3430061
    [Abstract] [Full Text] [Related]

  • 18. 5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons.
    Schroepfer GJ, Parish EJ, Kisic A, Jackson EM, Farley CM, Mott GE.
    Proc Natl Acad Sci U S A; 1982 May 15; 79(9):3042-6. PubMed ID: 6953447
    [Abstract] [Full Text] [Related]

  • 19. Inhibitors of sterol synthesis. Chemical synthesis and properties of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one and 25,26,26,26,27,27,27-heptafluorocholesterol and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Swaminathan S, Wilson WK, Pinkerton FD, Gerst N, Ramser M, Schroepfer GJ.
    J Lipid Res; 1993 Oct 15; 34(10):1805-23. PubMed ID: 8245728
    [Abstract] [Full Text] [Related]

  • 20. Sterol synthesis. Chemical synthesis of 5 alpha-cholest-7-en-3 beta, 14 alpha-diol.
    Pascal RA, Schroepfer GJ.
    J Lipid Res; 1980 Jan 15; 21(1):118-22. PubMed ID: 7354248
    [Abstract] [Full Text] [Related]

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