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414 related items for PubMed ID: 34474028

  • 1. Mechanisms of gefitinib-induced QT prolongation.
    Jie LJ, Li YD, Zhang HQ, Mao L, Xie HB, Zhou FG, Zhou TL, Xie D, Lin JL, Li GY, Cai BN, Zhang YH, Wang Y.
    Eur J Pharmacol; 2021 Nov 05; 910():174441. PubMed ID: 34474028
    [Abstract] [Full Text] [Related]

  • 2. Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells.
    Jie LJ, Wu WY, Li G, Xiao GS, Zhang S, Li GR, Wang Y.
    Br J Pharmacol; 2017 Feb 05; 174(3):254-266. PubMed ID: 27886373
    [Abstract] [Full Text] [Related]

  • 3. Enzastaurin cardiotoxicity: QT interval prolongation, negative inotropic responses and negative chronotropic action.
    Zhang HQ, Lin JL, Pan L, Mao L, Pang JL, Yuan Q, Li GY, Yi GS, Lin YB, Feng BL, Li YD, Wang Y, Jie LJ, Zhang YH.
    Biochem Pharmacol; 2023 Mar 05; 209():115443. PubMed ID: 36720353
    [Abstract] [Full Text] [Related]

  • 4. SKF-96365 blocks human ether-à-go-go-related gene potassium channels stably expressed in HEK 293 cells.
    Liu H, Yang L, Chen KH, Sun HY, Jin MW, Xiao GS, Wang Y, Li GR.
    Pharmacol Res; 2016 Feb 05; 104():61-9. PubMed ID: 26689773
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  • 5. Block of HERG human K(+) channel and IKr of guinea pig cardiomyocytes by chlorpromazine.
    Lee SY, Choi SY, Youm JB, Ho WK, Earm YE, Lee CO, Jo SH.
    J Cardiovasc Pharmacol; 2004 May 05; 43(5):706-14. PubMed ID: 15071359
    [Abstract] [Full Text] [Related]

  • 6. Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel.
    Ridley JM, Milnes JT, Hancox JC, Witchel HJ.
    J Mol Cell Cardiol; 2006 Jan 05; 40(1):107-18. PubMed ID: 16288909
    [Abstract] [Full Text] [Related]

  • 7. New in vitro model for proarrhythmia safety screening: IKs inhibition potentiates the QTc prolonging effect of IKr inhibitors in isolated guinea pig hearts.
    Kui P, Orosz S, Takács H, Sarusi A, Csík N, Rárosi F, Csekő C, Varró A, Papp JG, Forster T, Farkas AS, Farkas A.
    J Pharmacol Toxicol Methods; 2016 Jan 05; 80():26-34. PubMed ID: 27063345
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  • 8. Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome.
    Yue Y, Castrichini M, Srivastava U, Fabris F, Shah K, Li Z, Qu Y, El-Sherif N, Zhou Z, January C, Hussain MM, Jiang XC, Sobie EA, Wahren-Herlenius M, Chahine M, Capecchi PL, Laghi-Pasini F, Lazzerini PE, Boutjdir M.
    Circulation; 2015 Jul 28; 132(4):230-40. PubMed ID: 25995318
    [Abstract] [Full Text] [Related]

  • 9. Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.
    Davie C, Pierre-Valentin J, Pollard C, Standen N, Mitcheson J, Alexander P, Thong B.
    J Cardiovasc Electrophysiol; 2004 Nov 28; 15(11):1302-9. PubMed ID: 15574182
    [Abstract] [Full Text] [Related]

  • 10. The effects of isoflurane on the cardiac slowly activating delayed-rectifier potassium channel in Guinea pig ventricular myocytes.
    Suzuki A, Bosnjak ZJ, Kwok WM.
    Anesth Analg; 2003 May 28; 96(5):1308-1315. PubMed ID: 12707124
    [Abstract] [Full Text] [Related]

  • 11. Acute alteration of cardiac ECG, action potential, I(Kr) and the human ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77.
    Park MH, Park WS, Jo SH.
    Toxicol Appl Pharmacol; 2012 Jul 01; 262(1):60-9. PubMed ID: 22676973
    [Abstract] [Full Text] [Related]

  • 12. QT PRODACT: evaluation of the potential of compounds to cause QT interval prolongation by action potential assays using guinea-pig papillary muscles.
    Kii Y, Hayashi S, Tabo M, Shimosato T, Fukuda H, Itoh T, Amano H, Saito M, Morimoto H, Yamada K, Kanda A, Ishitsuka T, Yamazaki T, Kiuchi Y, Taniguchi S, Mori T, Shimizu S, Tsurubuchi Y, Yasuda S, Kitani S, Shimada C, Kobayashi K, Komeno M, Kasai C, Hombo T, Yamamoto K.
    J Pharmacol Sci; 2005 Jul 01; 99(5):449-57. PubMed ID: 16493186
    [Abstract] [Full Text] [Related]

  • 13. HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs.
    Bai YL, Liu HB, Sun B, Zhang Y, Li Q, Hu CW, Zhu JX, Gong DM, Teng X, Zhang Q, Yang BF, Dong DL.
    J Mol Cell Cardiol; 2011 Nov 01; 51(5):876-80. PubMed ID: 21820442
    [Abstract] [Full Text] [Related]

  • 14. Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel.
    Kang J, Chen XL, Wang H, Ji J, Cheng H, Incardona J, Reynolds W, Viviani F, Tabart M, Rampe D.
    Mol Pharmacol; 2005 Mar 01; 67(3):827-36. PubMed ID: 15548764
    [Abstract] [Full Text] [Related]

  • 15. Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization.
    Schwoerer AP, Blütner C, Brandt S, Binder S, Siebrands CC, Ehmke H, Friederich P.
    Anesthesiology; 2007 May 01; 106(5):967-76. PubMed ID: 17457128
    [Abstract] [Full Text] [Related]

  • 16. Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine.
    Scholz EP, Zitron E, Kiesecker C, Lueck S, Kathöfer S, Thomas D, Weretka S, Peth S, Kreye VA, Schoels W, Katus HA, Kiehn J, Karle CA.
    Naunyn Schmiedebergs Arch Pharmacol; 2003 Nov 01; 368(5):404-14. PubMed ID: 14557918
    [Abstract] [Full Text] [Related]

  • 17. Electrophysiological characterization of a small molecule activator on human ether-a-go-go-related gene (hERG) potassium channel.
    Dong X, Liu Y, Niu H, Wang G, Dong L, Zou A, Wang K.
    J Pharmacol Sci; 2019 Jul 01; 140(3):284-290. PubMed ID: 31481348
    [Abstract] [Full Text] [Related]

  • 18. Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells.
    Jehle J, Ficker E, Wan X, Deschenes I, Kisselbach J, Wiedmann F, Staudacher I, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D.
    Br J Pharmacol; 2013 Mar 01; 168(5):1215-29. PubMed ID: 23061993
    [Abstract] [Full Text] [Related]

  • 19. Galantamine (Reminyl) delays cardiac ventricular repolarization and prolongs the QT interval by blocking the HERG current.
    Vigneault P, Bourgault S, Kaddar N, Caillier B, Pilote S, Patoine D, Simard C, Drolet B.
    Eur J Pharmacol; 2012 Apr 15; 681(1-3):68-74. PubMed ID: 22366430
    [Abstract] [Full Text] [Related]

  • 20. Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine.
    Lee SY, Kim YJ, Kim KT, Choe H, Jo SH.
    Br J Pharmacol; 2006 Jun 15; 148(4):499-509. PubMed ID: 16633353
    [Abstract] [Full Text] [Related]

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