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325 related items for PubMed ID: 34486521

  • 1. Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.
    Bacic L, Gaullier G, Sabantsev A, Lehmann LC, Brackmann K, Dimakou D, Halic M, Hewitt G, Boulton SJ, Deindl S.
    Elife; 2021 Sep 06; 10():. PubMed ID: 34486521
    [Abstract] [Full Text] [Related]

  • 2. Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1·PARP1·nucleosome intermediate.
    Gottschalk AJ, Trivedi RD, Conaway JW, Conaway RC.
    J Biol Chem; 2012 Dec 21; 287(52):43527-32. PubMed ID: 23132853
    [Abstract] [Full Text] [Related]

  • 3. Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1.
    Bacic L, Gaullier G, Mohapatra J, Mao G, Brackmann K, Panfilov M, Liszczak G, Sabantsev A, Deindl S.
    Nat Commun; 2024 Feb 02; 15(1):1000. PubMed ID: 38307862
    [Abstract] [Full Text] [Related]

  • 4. Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.
    Lehmann LC, Hewitt G, Aibara S, Leitner A, Marklund E, Maslen SL, Maturi V, Chen Y, van der Spoel D, Skehel JM, Moustakas A, Boulton SJ, Deindl S.
    Mol Cell; 2017 Dec 07; 68(5):847-859.e7. PubMed ID: 29220652
    [Abstract] [Full Text] [Related]

  • 5. Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling.
    Ooi SK, Sato S, Tomomori-Sato C, Zhang Y, Wen Z, Banks CAS, Washburn MP, Unruh JR, Florens L, Conaway RC, Conaway JW.
    Proc Natl Acad Sci U S A; 2021 Sep 07; 118(36):. PubMed ID: 34465625
    [Abstract] [Full Text] [Related]

  • 6. Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
    Hewitt G, Borel V, Segura-Bayona S, Takaki T, Ruis P, Bellelli R, Lehmann LC, Sommerova L, Vancevska A, Tomas-Loba A, Zhu K, Cooper C, Fugger K, Patel H, Goldstone R, Schneider-Luftman D, Herbert E, Stamp G, Brough R, Pettitt S, Lord CJ, West SC, Ahel I, Ahel D, Chapman JR, Deindl S, Boulton SJ.
    Mol Cell; 2021 Feb 18; 81(4):767-783.e11. PubMed ID: 33333017
    [Abstract] [Full Text] [Related]

  • 7. Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
    Lehmann LC, Bacic L, Hewitt G, Brackmann K, Sabantsev A, Gaullier G, Pytharopoulou S, Degliesposti G, Okkenhaug H, Tan S, Costa A, Skehel JM, Boulton SJ, Deindl S.
    Cell Rep; 2020 Dec 22; 33(12):108529. PubMed ID: 33357431
    [Abstract] [Full Text] [Related]

  • 8. The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks.
    Blessing C, Mandemaker IK, Gonzalez-Leal C, Preisser J, Schomburg A, Ladurner AG.
    Mol Cell; 2020 Dec 03; 80(5):862-875.e6. PubMed ID: 33275888
    [Abstract] [Full Text] [Related]

  • 9. Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome.
    Wang L, Chen K, Chen Z.
    Nat Commun; 2021 Jul 01; 12(1):4057. PubMed ID: 34210977
    [Abstract] [Full Text] [Related]

  • 10. Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
    Mohapatra J, Tashiro K, Beckner RL, Sierra J, Kilgore JA, Williams NS, Liszczak G.
    Elife; 2021 Dec 07; 10():. PubMed ID: 34874266
    [Abstract] [Full Text] [Related]

  • 11. Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.
    Kurgina TA, Moor NA, Kutuzov MM, Naumenko KN, Ukraintsev AA, Lavrik OI.
    Commun Biol; 2021 Nov 03; 4(1):1259. PubMed ID: 34732825
    [Abstract] [Full Text] [Related]

  • 12. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.
    Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ.
    Science; 2009 Sep 04; 325(5945):1240-3. PubMed ID: 19661379
    [Abstract] [Full Text] [Related]

  • 13. A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene.
    Singh HR, Nardozza AP, Möller IR, Knobloch G, Kistemaker HAV, Hassler M, Harrer N, Blessing C, Eustermann S, Kotthoff C, Huet S, Mueller-Planitz F, Filippov DV, Timinszky G, Rand KD, Ladurner AG.
    Mol Cell; 2017 Dec 07; 68(5):860-871.e7. PubMed ID: 29220653
    [Abstract] [Full Text] [Related]

  • 14. ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.
    Tsuda M, Cho K, Ooka M, Shimizu N, Watanabe R, Yasui A, Nakazawa Y, Ogi T, Harada H, Agama K, Nakamura J, Asada R, Fujiike H, Sakuma T, Yamamoto T, Murai J, Hiraoka M, Koike K, Pommier Y, Takeda S, Hirota K.
    PLoS One; 2017 Dec 07; 12(11):e0188320. PubMed ID: 29149203
    [Abstract] [Full Text] [Related]

  • 15. Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
    Gaullier G, Roberts G, Muthurajan UM, Bowerman S, Rudolph J, Mahadevan J, Jha A, Rae PS, Luger K.
    PLoS One; 2020 Dec 07; 15(11):e0240932. PubMed ID: 33141820
    [Abstract] [Full Text] [Related]

  • 16. The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment.
    Juhász S, Smith R, Schauer T, Spekhardt D, Mamar H, Zentout S, Chapuis C, Huet S, Timinszky G.
    Sci Adv; 2020 Dec 07; 6(51):. PubMed ID: 33355125
    [Abstract] [Full Text] [Related]

  • 17. Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.
    Bilokapic S, Suskiewicz MJ, Ahel I, Halic M.
    Nature; 2020 Sep 07; 585(7826):609-613. PubMed ID: 32939087
    [Abstract] [Full Text] [Related]

  • 18. The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage.
    Sellou H, Lebeaupin T, Chapuis C, Smith R, Hegele A, Singh HR, Kozlowski M, Bultmann S, Ladurner AG, Timinszky G, Huet S.
    Mol Biol Cell; 2016 Dec 01; 27(24):3791-3799. PubMed ID: 27733626
    [Abstract] [Full Text] [Related]

  • 19. Poly(ADP‑ribose) polymerase 1/2 inhibitors decrease the ubiquitination of ALC1 mediated by CHFR in breast cancer.
    Wang Y, Wang Y, Wang N, You L, Long F, Shao C, Wang Y, Wu J.
    Oncol Rep; 2019 Oct 01; 42(4):1467-1474. PubMed ID: 31322269
    [Abstract] [Full Text] [Related]

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