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387 related items for PubMed ID: 34544834

  • 1. Somatostatin-Positive Interneurons Contribute to Seizures in SCN8A Epileptic Encephalopathy.
    Wengert ER, Miralles RM, Wedgwood KCA, Wagley PK, Strohm SM, Panchal PS, Idrissi AM, Wenker IC, Thompson JA, Gaykema RP, Patel MK.
    J Neurosci; 2021 Nov 03; 41(44):9257-9273. PubMed ID: 34544834
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  • 3. Prax330 reduces persistent and resurgent sodium channel currents and neuronal hyperexcitability of subiculum neurons in a mouse model of SCN8A epileptic encephalopathy.
    Wengert ER, Saga AU, Panchal PS, Barker BS, Patel MK.
    Neuropharmacology; 2019 Nov 01; 158():107699. PubMed ID: 31278928
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  • 5. The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.
    Baker EM, Thompson CH, Hawkins NA, Wagnon JL, Wengert ER, Patel MK, George AL, Meisler MH, Kearney JA.
    Epilepsia; 2018 Jun 01; 59(6):1166-1176. PubMed ID: 29782051
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  • 6. Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy.
    Thompson JA, Miralles RM, Wengert ER, Wagley PK, Yu W, Wenker IC, Patel MK.
    Epilepsia Open; 2022 Jun 01; 7(2):280-292. PubMed ID: 34826216
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  • 10. NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.
    Johnson JP, Focken T, Khakh K, Tari PK, Dube C, Goodchild SJ, Andrez JC, Bankar G, Bogucki D, Burford K, Chang E, Chowdhury S, Dean R, de Boer G, Decker S, Dehnhardt C, Feng M, Gong W, Grimwood M, Hasan A, Hussainkhel A, Jia Q, Lee S, Li J, Lin S, Lindgren A, Lofstrand V, Mezeyova J, Namdari R, Nelkenbrecher K, Shuart NG, Sojo L, Sun S, Taron M, Waldbrook M, Weeratunge D, Wesolowski S, Williams A, Wilson M, Xie Z, Yoo R, Young C, Zenova A, Zhang W, Cutts AJ, Sherrington RP, Pimstone SN, Winquist R, Cohen CJ, Empfield JR.
    Elife; 2022 Mar 02; 11():. PubMed ID: 35234610
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  • 12. Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy.
    de Kovel CG, Meisler MH, Brilstra EH, van Berkestijn FM, van 't Slot R, van Lieshout S, Nijman IJ, O'Brien JE, Hammer MF, Estacion M, Waxman SG, Dib-Hajj SD, Koeleman BP.
    Epilepsy Res; 2014 Nov 02; 108(9):1511-8. PubMed ID: 25239001
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  • 13. Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy.
    Lopez-Santiago LF, Yuan Y, Wagnon JL, Hull JM, Frasier CR, O'Malley HA, Meisler MH, Isom LL.
    Proc Natl Acad Sci U S A; 2017 Feb 28; 114(9):2383-2388. PubMed ID: 28193882
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  • 14. Genetic and clinical features of SCN8A developmental and epileptic encephalopathy.
    Kim HJ, Yang D, Kim SH, Kim B, Kim HD, Lee JS, Choi JR, Lee ST, Kang HC.
    Epilepsy Res; 2019 Dec 28; 158():106222. PubMed ID: 31675620
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  • 15. Prominent role of forebrain excitatory neurons in SCN8A encephalopathy.
    Bunton-Stasyshyn RKA, Wagnon JL, Wengert ER, Barker BS, Faulkner A, Wagley PK, Bhatia K, Jones JM, Maniaci MR, Parent JM, Goodkin HP, Patel MK, Meisler MH.
    Brain; 2019 Feb 01; 142(2):362-375. PubMed ID: 30601941
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  • 16. A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy.
    Estacion M, O'Brien JE, Conravey A, Hammer MF, Waxman SG, Dib-Hajj SD, Meisler MH.
    Neurobiol Dis; 2014 Sep 01; 69():117-23. PubMed ID: 24874546
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  • 17. The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control.
    Johnson JP, Focken T, Karimi Tari P, Dube C, Goodchild SJ, Andrez JC, Bankar G, Burford K, Chang E, Chowdhury S, Christabel J, Dean R, de Boer G, Dehnhardt C, Gong W, Grimwood M, Hussainkhel A, Jia Q, Khakh K, Lee S, Li J, Lin S, Lindgren A, Lofstrand V, Mezeyova J, Nelkenbrecher K, Shuart NG, Sojo L, Sun S, Waldbrook M, Wesolowski S, Wilson M, Xie Z, Zenova A, Zhang W, Scott FL, Cutts AJ, Sherrington RP, Winquist R, Cohen CJ, Empfield JR.
    Br J Pharmacol; 2024 Oct 01; 181(20):3993-4011. PubMed ID: 38922847
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  • 18. Clinical study of 19 patients with SCN8A-related epilepsy: Two modes of onset regarding EEG and seizures.
    Denis J, Villeneuve N, Cacciagli P, Mignon-Ravix C, Lacoste C, Lefranc J, Napuri S, Damaj L, Villega F, Pedespan JM, Moutton S, Mignot C, Doummar D, Lion-François L, Gataullina S, Dulac O, Martin M, Gueden S, Lesca G, Julia S, Cances C, Journel H, Altuzarra C, Ben Zeev B, Afenjar A, Barth M, Villard L, Milh M.
    Epilepsia; 2019 May 01; 60(5):845-856. PubMed ID: 31026061
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  • 19. The SCN8A encephalopathy mutation p.Ile1327Val displays elevated sensitivity to the anticonvulsant phenytoin.
    Barker BS, Ottolini M, Wagnon JL, Hollander RM, Meisler MH, Patel MK.
    Epilepsia; 2016 Sep 01; 57(9):1458-66. PubMed ID: 27375106
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  • 20. SCN8A mutations in Chinese patients with early onset epileptic encephalopathy and benign infantile seizures.
    Wang J, Gao H, Bao X, Zhang Q, Li J, Wei L, Wu X, Chen Y, Yu S.
    BMC Med Genet; 2017 Sep 18; 18(1):104. PubMed ID: 28923014
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