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168 related items for PubMed ID: 34556859

  • 1. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.
    Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ.
    Nat Chem Biol; 2021 Nov; 17(11):1148-1156. PubMed ID: 34556859
    [Abstract] [Full Text] [Related]

  • 2. Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.
    Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ.
    ACS Chem Biol; 2016 Aug 19; 11(8):2195-205. PubMed ID: 27227314
    [Abstract] [Full Text] [Related]

  • 3. Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.
    Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR.
    Cell; 2014 Jul 31; 158(3):534-48. PubMed ID: 25018104
    [Abstract] [Full Text] [Related]

  • 4. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
    Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR.
    Cell; 2009 Aug 07; 138(3):562-75. PubMed ID: 19665977
    [Abstract] [Full Text] [Related]

  • 5. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
    Concha NO, Smallwood A, Bonnette W, Totoritis R, Zhang G, Federowicz K, Yang J, Qi H, Chen S, Campobasso N, Choudhry AE, Shuster LE, Evans KA, Ralph J, Sweitzer S, Heerding DA, Buser CA, Su DS, DeYoung MP.
    Mol Pharmacol; 2015 Dec 07; 88(6):1011-23. PubMed ID: 26438213
    [Abstract] [Full Text] [Related]

  • 6. Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.
    Newbatt Y, Hardcastle A, McAndrew PC, Strover JA, Mirza A, Morgan GJ, Burke R, Davies FE, Collins I, van Montfort RL.
    J Biomol Screen; 2013 Mar 07; 18(3):298-308. PubMed ID: 23139381
    [Abstract] [Full Text] [Related]

  • 7. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.
    Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ.
    Nat Chem Biol; 2012 Dec 07; 8(12):982-9. PubMed ID: 23086298
    [Abstract] [Full Text] [Related]

  • 8. Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
    Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR.
    PLoS One; 2019 Dec 07; 14(1):e0209824. PubMed ID: 30625178
    [Abstract] [Full Text] [Related]

  • 9. The endoplasmic reticulum stress sensor IRE1α protects cells from apoptosis induced by the coronavirus infectious bronchitis virus.
    Fung TS, Liao Y, Liu DX.
    J Virol; 2014 Nov 07; 88(21):12752-64. PubMed ID: 25142592
    [Abstract] [Full Text] [Related]

  • 10. ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras.
    Blazanin N, Son J, Craig-Lucas AB, John CL, Breech KJ, Podolsky MA, Glick AB.
    Proc Natl Acad Sci U S A; 2017 Sep 12; 114(37):9900-9905. PubMed ID: 28847931
    [Abstract] [Full Text] [Related]

  • 11. Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α.
    Feldman HC, Maly DJ.
    Methods Mol Biol; 2017 Sep 12; 1513():233-242. PubMed ID: 27807842
    [Abstract] [Full Text] [Related]

  • 12. Opposite Roles of RNase and Kinase Activities of Inositol-Requiring Enzyme 1 (IRE1) on HSV-1 Replication.
    Su A, Wang H, Li Y, Wang X, Chen D, Wu Z.
    Viruses; 2017 Aug 23; 9(9):. PubMed ID: 28832521
    [Abstract] [Full Text] [Related]

  • 13. SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
    Nguyen LC, Renner DM, Silva D, Yang D, Parenti NA, Medina KM, Nicolaescu V, Gula H, Drayman N, Valdespino A, Mohamed A, Dann C, Wannemo K, Robinson-Mailman L, Gonzalez A, Stock L, Cao M, Qiao Z, Moellering RE, Tay S, Randall G, Beers MF, Rosner MR, Oakes SA, Weiss SR.
    mBio; 2022 Oct 26; 13(5):e0241522. PubMed ID: 36125275
    [Abstract] [Full Text] [Related]

  • 14. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.
    Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR.
    Biochem Biophys Res Commun; 2008 Jan 25; 365(4):777-83. PubMed ID: 18035051
    [Abstract] [Full Text] [Related]

  • 15. HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction.
    Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, Samali A.
    PLoS Biol; 2010 Jul 06; 8(7):e1000410. PubMed ID: 20625543
    [Abstract] [Full Text] [Related]

  • 16. A Human IRE1 Inhibitor Blocks the Unfolded Protein Response in the Pathogenic Fungus Aspergillus fumigatus and Suggests Noncanonical Functions within the Pathway.
    Guirao-Abad JP, Weichert M, Albee A, Deck K, Askew DS.
    mSphere; 2020 Oct 21; 5(5):. PubMed ID: 33087521
    [Abstract] [Full Text] [Related]

  • 17. The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.
    Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ.
    J Clin Invest; 2005 Feb 21; 115(2):268-81. PubMed ID: 15690081
    [Abstract] [Full Text] [Related]

  • 18. Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor.
    Bartoszewska S, Króliczewski J, Crossman DK, Pogorzelska A, Bagiński M, Collawn JF, Bartoszewski R.
    Cell Mol Biol Lett; 2021 Mar 17; 26(1):11. PubMed ID: 33730996
    [Abstract] [Full Text] [Related]

  • 19. Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.
    Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA.
    Cancer Res; 2019 Dec 15; 79(24):6190-6203. PubMed ID: 31672843
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia.
    Sun H, Lin DC, Guo X, Kharabi Masouleh B, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP.
    Oncotarget; 2016 Apr 05; 7(14):18736-49. PubMed ID: 26934650
    [Abstract] [Full Text] [Related]

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